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Substrate Report for: Alpha-amanitin-proprotein

Name Class
Alpha-amanitin-proproteinTypeNatural
Toxin
Macrocycle
Peptide
Other_Name (5)
PaperCzekster_2017_Nat.Commun_8_1045
Structure5N4B
5N4C
5N4D
5N4E
Comment25mer macrocyclization substrate: IWGIGCNPWTAEHVDQTLASGNDIC. The 25mer is the post proline product (A0A067SLB9 AAMA1_GALM3) Major toxin belonging to the bicyclic octapeptides amatoxins that acts by binding non-competitively to RNA polymerase II and greatly slowing the elongation of transcripts from target promoters
Gene_locus9agar-h2e7q8
FamilyS9N_PPCE_Peptidase_S9

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Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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