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Substrate Report for: Acetylcholine

Name Class
AcetylcholineTypeAcetate
Trimethylammonium
Natural
Choline ester
Other_Name (5)
Chemical_Nomenclature2-(Acetyloxy)-N,N,N,-trimethylethanaminium
FormulaC7H16NO2
CAS_number51-84-3
MW146.20
Kinetic_parameterAcetylcholine_WT_eleel-ACHE
Acetylcholine_WT_human-BCHE
Acetylcholine_D70G_human-BCHE
PaperLockridge_1990_Pharmacol.Ther_47_35
Davies_1960_Can.J.Biochem.Physiol_38_545
Hasan_1980_J.Biol.Chem_255_3898
Structure2HA4
2ACE
CommentAcetylcholine is a neurotransmitter found at neuromuscular junctions, autonomic ganglia, parasympathetic effector junctions, a subset of sympathetic effector junctions, and at many sites in the central nervous system. Entry of reference human-ACHE, (bromide 66-23-9 or chloride 60-31-1 or iodide 2260-50-6). So far the enzymes hydrolyzing acetylcholine in plants or bacteria are unrelated to animal AChE or any other alpha/beta hydrolases. The enzyme described by Rochu et al. in Pseudomonas fluorescens belongs to SBP_bac_8 (PF13416), the enzyme described by Sanchez et al. is a SGNH_hydrolase (CL0264). So called acetylcholinesterase of plants are also SGNH_hydrolase Yamamoto et al., Sagane et al.
Kin_SubstrateAcetylcholine
Gene_locus (10)
CID (5)
FamilyACHE
BCHE
Cholinesterase
Cholinesterase-like
InChIKeyOIPILFWXSMYKGL-UHFFFAOYSA-N
CanonicalSMILESCC(=O)OCC[N+](C)(C)C
InChIInChI=1S/C7H16NO2/c1-7(9)10-6-5-8(2,3)4/h5-6H2,1-4H3/q+1
WikipediaAcetylcholine

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Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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