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Substrate Report for: AZD1979

Name Class
AZD1979TypeNot A/B H target
Azaspiro
Oxadiazol
Azetidin
Other_Name (8)
Chemical_Nomenclature[5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl]-[3-[4-(2-oxa-6-azaspiro[3.3]heptan-6-ylmethyl)phenoxy]azetidin-1-yl]methanone
FormulaC25H26N4O5
CAS_number1254035-84-1
MW462.5
Paper (3)
CommentAZD1979 is a melanin concentrating hormone receptor 1 (MCHr1) antagonist designed for the treatment of obesity.. EPHX1 hydration and ring opening of the oxetanyl moiety of AZD1979 and is inhibited by Progabide
Gene_locushuman-EPHX1
CID49801838
FamilyEpoxide_hydrolase
InChIKeyBKKPIQPFRAPEAY-UHFFFAOYSA-N
CanonicalSMILESCOC1=CC=C(C=C1)C2=NN=C(O2)C(=O)N3CC(C3)OC4=CC=C(C=C4)CN5CC6(C5)COC6
InChIInChI=1S/C25H26N4O5/c1-31-19-8-4-18(5-9-19)22-26-27-23(34-22)24(30)29-11-21(12-29)33-20-6-2-17(3-7-20)10-28-13-25(14-28)15-32-16-25/h2-9,21H,10-16H2,1H3

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Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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