Valle et al. describe 19 SNPs in the ACHE gene correlated with catalytic properties and general cardiovascular functions. 7 coding (cSNPs), of which 4 are non-synonymous (one new). Protein expression of ACHE non-synonymous variant (D134H)D134H (SNP6) is impaired. D134H instability could be reversed in the D134H/R136Q mutant.Variation of the butyrylcholinesterase (BChE) and acetylcholinesterase (AChE) genes in coronary artery disease are also analysed by Scacchi et al.