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Inhibitor Report for: ABX-1431

Name Class
ABX-1431TypePiperazine
Carbamate
Pyrrolidine
Trifluoro
Other_Name (5)
Chemical_Nomenclature1,1,1,3,3,3-hexafluoropropan-2-yl 4-[[2-pyrrolidin-1-yl-4-(trifluoromethyl)phenyl]methyl]piperazine-1-carboxylate
FormulaC20H22F9N3O2
CAS_number1446817-84-0
MW507.4
Paper (5)
CommentMonoacylglycerol lipase (human-MGLL) inhibitor (IC50 14 nM) .Increases brain 2-AG concentrations, and suppresses pain behavior. ABX-1431 has been shown to reduce tics in patients with Tourette syndrome
Gene_locushuman-MGLL
CID71657619
FamilyMonoglyceridelipase_lysophospholip
InChIKeySQZJGTOZFRNWCX-UHFFFAOYSA-N
CanonicalSMILESC1CCN(C1)C2=C(C=CC(=C2)C(F)(F)F)CN3CCN(CC3)C(=O)OC(C(F)(F)F)C(F)(F)F
InChIInChI=1S/C20H22F9N3O2/c21-18(22,23)14-4-3-13(15(11-14)31-5-1-2-6-31)12-30-7-9-32(10-8-30)17(33)34-16(19(24,25)26)20(27,28)29/h3-4,11,16H,1-2,5-10,12H2

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Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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