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Family Report for: ABHD11-Acetyl_transferase

Name Class
ABHD11-Acetyl_transferaseRank2
FamilyAbhydrolase_6
Gene_locus (423)
Gene_locus_Frgt (31)
BlockX
LED_DatabaseabH07.01
PaperBailey_2020_Nat.Commun_11_4046
Liu_2020_Front.Cell.Dev.Biol_8_570
Kruis_2017_Metab.Eng_41_92
Navia-Paldanius_2016_Eur.J.Pharm.Sci_93_253
Arya_2017_Biochem.Biophys.Res.Commun_487_875
Park_2008_J.Mol.Biol_376_1426
Vijayakumar_2016_Plant.Physiol_170_180
Chen_2017_Oncotarget_8_28176
Lin_2014_Med.Oncol_31_42
Yang_2016_Tumour.Biol_37_1183
Francelle_2015_Neurobiol.Aging_36_1601.e7
Park_2019_Neurosci.Res_147_58
Wiedl_2011_J.Proteomics_74_1884
Golla_2022_Noncoding.RNA_8_21
Structure7C4D
3BF7
3BF8
CommentABHD11 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. ABHD11 is an enzyme acting on triacylglycerol. Many yeasts are able to produce ethyl acetate. Enzyme Eat1 from the yeast Wickerhamomyces anomalus showed alcohol acetyltransferase activity with ethanol and acetyl-CoA. Homologs of eat1 are responsible for most ethyl acetate synthesis in known ethyl acetate-producing yeasts, including S. cerevisiae, and are only distantly related to known alcohol acetyltransferases. Structure of ybfF protein from Escherichia coli (esterase of the large substrates, palmitoyl coenzyme A and malonyl coenzyme A) has been solved. Liu et al. published that: ABHD11 is critical for embryonic stem cell expansion, differentiation and lipid metabolic homeostasis. ABHD11-AS1 is An Emerging Long Non-Coding RNA (lncRNA) with Clinical Significance in Human Malignancies
NewsMAY-10-2017
Inhibitor (6)
Substrate (7)

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Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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