Family Report for: ABHD11-Acetyl_transferase
| ABHD11-Acetyl_transferase | Rank | 2 |
|---|
| Family | Abhydrolase_6 |
| Gene_locus (423) |
| Gene_locus_Frgt (31) |
| Block | X |
| LED_Database | abH07.01 |
| Paper (14) |
| Structure | 7C4D |
| | 3BF7 |
| | 3BF8 |
| Comment | ABHD11 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. ABHD11 is an enzyme acting on triacylglycerol. Many yeasts are able to produce ethyl acetate. Enzyme Eat1 from the yeast Wickerhamomyces anomalus showed alcohol acetyltransferase activity with ethanol and acetyl-CoA. Homologs of eat1 are responsible for most ethyl acetate synthesis in known ethyl acetate-producing yeasts, including S. cerevisiae, and are only distantly related to known alcohol acetyltransferases. Structure of ybfF protein from Escherichia coli (esterase of the large substrates, palmitoyl coenzyme A and malonyl coenzyme A) has been solved. Liu et al. published that: ABHD11 is critical for embryonic stem cell expansion, differentiation and lipid metabolic homeostasis. ABHD11-AS1 is An Emerging Long Non-Coding RNA (lncRNA) with Clinical Significance in Human Malignancies |
| News | MAY-10-2017 |
| Inhibitor | ML226 |
| | ML211 |
| | Piperidinyl-1,2,3-triazole-urea-inhibitor-2 |
| | ABP-C6 |
| | NBD-TG |
| | NBD-HE-HP |
| Substrate (7) |
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