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LongText Report for: 8boz-pdb

Name Class
8boz-pdb
HEADER    HYDROLASE                               15-NOV-22   8BOZ              
TITLE     STRUCTURE OF THE ADHERENT-INVASIVE ESCHERICHIA COLI TLE3/TLI3 T6SS    
TITLE    2 EFFECTOR/IMMUNITY COMPLEX                                            
COMPND    MOL_ID: 1;                                                            
COMPND   2 MOLECULE: TRANSMEMBRANE PROTEIN;                                     
COMPND   3 CHAIN: A, C, E, G, I, K, M, O;                                       
COMPND   4 ENGINEERED: YES;                                                     
COMPND   5 MOL_ID: 2;                                                           
COMPND   6 MOLECULE: LIPOPROTEIN;                                               
COMPND   7 CHAIN: B, D, F, H, J, L, N, P;                                       
COMPND   8 ENGINEERED: YES                                                      
SOURCE    MOL_ID: 1;                                                            
SOURCE   2 ORGANISM_SCIENTIFIC: ESCHERICHIA COLI;                               
SOURCE   3 ORGANISM_TAXID: 562;                                                 
SOURCE   4 GENE: FPI65_17315;                                                   
SOURCE   5 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE   6 EXPRESSION_SYSTEM_TAXID: 562;                                        
SOURCE   7 MOL_ID: 2;                                                           
SOURCE   8 ORGANISM_SCIENTIFIC: ESCHERICHIA COLI;                               
SOURCE   9 ORGANISM_TAXID: 562;                                                 
SOURCE  10 GENE: FPI65_17310;                                                   
SOURCE  11 EXPRESSION_SYSTEM: ESCHERICHIA COLI;                                 
SOURCE  12 EXPRESSION_SYSTEM_TAXID: 562                                         
KEYWDS    PHOSPHOLIPASE, IMMUNITY, ADHERENT-INVASIVE ESCHERICHIA COLI (AIEC), , 
KEYWDS   2 PROTEIN SECRETION, PROTEIN STRUCTURE, ALPHAFOLD2, HYDROLASE          
EXPDTA    X-RAY DIFFRACTION                                                     
AUTHOR    C.CAMBILLAU,A.ROUSSEL                                                 
REVDAT   1   08-FEB-23 8BOZ    0                                                
JRNL        AUTH   T.T.H.LE,C.KELLENBERGER,M.BOYER,P.SANTUCCI,N.FLAUGNATTI,     
JRNL        AUTH 2 E.CASCALES,A.ROUSSEL,S.CANAAN,L.JOURNET,C.CAMBILLAU          
JRNL        TITL   ACTIVITY AND CRYSTAL STRUCTURE OF THE ADHERENT-INVASIVE      
JRNL        TITL 2 ESCHERICHIA COLI TLE3/TLI3 T6SS EFFECTOR/IMMUNITY COMPLEX    
JRNL        TITL 3 DETERMINED USING AN ALPHAFOLD2 PREDICTED MODEL.              
JRNL        REF    INT J MOL SCI                 V.  24       2023              
JRNL        REFN                   ESSN 1422-0067                               
JRNL        PMID   36675258                                                     
JRNL        DOI    10.3390/IJMS24021740                                         
REMARK   2                                                                      
REMARK   2 RESOLUTION.    3.60 ANGSTROMS.                                       
REMARK   3                                                                      
REMARK   3 REFINEMENT.                                                          
REMARK   3   PROGRAM     : PHENIX (1.19.2_4158: ???)                            
REMARK   3   AUTHORS     : PAUL ADAMS,PAVEL AFONINE,VINCENT CHEN,IAN            
REMARK   3               : DAVIS,KRESHNA GOPAL,RALF GROSSE-KUNSTLEVE,           
REMARK   3               : LI-WEI HUNG,ROBERT IMMORMINO,TOM IOERGER,            
REMARK   3               : AIRLIE MCCOY,ERIK MCKEE,NIGEL MORIARTY,              
REMARK   3               : REETAL PAI,RANDY READ,JANE RICHARDSON,               
REMARK   3               : DAVID RICHARDSON,TOD ROMO,JIM SACCHETTINI,           
REMARK   3               : NICHOLAS SAUTER,JACOB SMITH,LAURENT                  
REMARK   3               : STORONI,TOM TERWILLIGER,PETER ZWART                  
REMARK   3                                                                      
REMARK   3    REFINEMENT TARGET : ML                                            
REMARK   3                                                                      
REMARK   3  DATA USED IN REFINEMENT.                                            
REMARK   3   RESOLUTION RANGE HIGH (ANGSTROMS) : 3.60                           
REMARK   3   RESOLUTION RANGE LOW  (ANGSTROMS) : 48.74                          
REMARK   3   MIN(FOBS/SIGMA_FOBS)              : 1.350                          
REMARK   3   COMPLETENESS FOR RANGE        (%) : 98.9                           
REMARK   3   NUMBER OF REFLECTIONS             : 78957                          
REMARK   3                                                                      
REMARK   3  FIT TO DATA USED IN REFINEMENT.                                     
REMARK   3   R VALUE     (WORKING + TEST SET) : 0.234                           
REMARK   3   R VALUE            (WORKING SET) : 0.233                           
REMARK   3   FREE R VALUE                     : 0.268                           
REMARK   3   FREE R VALUE TEST SET SIZE   (%) : 5.000                           
REMARK   3   FREE R VALUE TEST SET COUNT      : 3949                            
REMARK   3                                                                      
REMARK   3  FIT TO DATA USED IN REFINEMENT (IN BINS).                           
REMARK   3   BIN  RESOLUTION RANGE  COMPL.    NWORK NFREE   RWORK  RFREE        
REMARK   3     1 48.7400 - 10.9000    0.96     2621   139  0.2406 0.2476        
REMARK   3     2 10.8900 -  8.6600    0.98     2657   139  0.1797 0.1924        
REMARK   3     3  8.6600 -  7.5700    0.98     2657   140  0.1886 0.2151        
REMARK   3     4  7.5700 -  6.8800    0.98     2668   141  0.2024 0.2213        
REMARK   3     5  6.8800 -  6.3900    0.99     2714   142  0.2137 0.2417        
REMARK   3     6  6.3900 -  6.0100    0.99     2666   141  0.2247 0.2735        
REMARK   3     7  6.0100 -  5.7100    0.99     2671   140  0.2275 0.2992        
REMARK   3     8  5.7100 -  5.4600    0.99     2707   143  0.2275 0.2463        
REMARK   3     9  5.4600 -  5.2500    1.00     2667   140  0.2268 0.2819        
REMARK   3    10  5.2500 -  5.0700    0.99     2707   143  0.2232 0.2616        
REMARK   3    11  5.0700 -  4.9100    1.00     2704   142  0.2185 0.2432        
REMARK   3    12  4.9100 -  4.7700    0.99     2670   141  0.2177 0.2598        
REMARK   3    13  4.7700 -  4.6500    0.99     2698   142  0.2173 0.2626        
REMARK   3    14  4.6500 -  4.5300    0.99     2636   139  0.2279 0.3047        
REMARK   3    15  4.5300 -  4.4300    0.99     2736   144  0.2271 0.2722        
REMARK   3    16  4.4300 -  4.3400    0.99     2677   140  0.2282 0.2874        
REMARK   3    17  4.3400 -  4.2500    0.99     2642   140  0.2411 0.2673        
REMARK   3    18  4.2500 -  4.1700    0.99     2699   142  0.2360 0.2796        
REMARK   3    19  4.1700 -  4.1000    0.99     2703   142  0.2469 0.3044        
REMARK   3    20  4.1000 -  4.0300    0.99     2671   141  0.2591 0.3156        
REMARK   3    21  4.0300 -  3.9600    0.99     2675   140  0.2679 0.3106        
REMARK   3    22  3.9600 -  3.9000    0.99     2717   143  0.2813 0.3245        
REMARK   3    23  3.9000 -  3.8400    0.99     2665   141  0.2822 0.3024        
REMARK   3    24  3.8400 -  3.7900    0.99     2651   139  0.2784 0.3187        
REMARK   3    25  3.7900 -  3.7400    0.99     2665   140  0.3068 0.3585        
REMARK   3    26  3.7400 -  3.6900    0.99     2761   146  0.3052 0.3396        
REMARK   3    27  3.6900 -  3.6400    0.99     2643   139  0.3116 0.3663        
REMARK   3    28  3.6400 -  3.6000    0.99     2660   140  0.3405 0.3758        
REMARK   3                                                                      
REMARK   3  BULK SOLVENT MODELLING.                                             
REMARK   3   METHOD USED        : FLAT BULK SOLVENT MODEL                       
REMARK   3   SOLVENT RADIUS     : 1.11                                          
REMARK   3   SHRINKAGE RADIUS   : 0.90                                          
REMARK   3   K_SOL              : NULL                                          
REMARK   3   B_SOL              : NULL                                          
REMARK   3                                                                      
REMARK   3  ERROR ESTIMATES.                                                    
REMARK   3   COORDINATE ERROR (MAXIMUM-LIKELIHOOD BASED)     : 0.560            
REMARK   3   PHASE ERROR (DEGREES, MAXIMUM-LIKELIHOOD BASED) : 27.510           
REMARK   3                                                                      
REMARK   3  B VALUES.                                                           
REMARK   3   FROM WILSON PLOT           (A**2) : NULL                           
REMARK   3   MEAN B VALUE      (OVERALL, A**2) : NULL                           
REMARK   3   OVERALL ANISOTROPIC B VALUE.                                       
REMARK   3    B11 (A**2) : NULL                                                 
REMARK   3    B22 (A**2) : NULL                                                 
REMARK   3    B33 (A**2) : NULL                                                 
REMARK   3    B12 (A**2) : NULL                                                 
REMARK   3    B13 (A**2) : NULL                                                 
REMARK   3    B23 (A**2) : NULL                                                 
REMARK   3                                                                      
REMARK   3  TWINNING INFORMATION.                                               
REMARK   3   FRACTION: NULL                                                     
REMARK   3   OPERATOR: NULL                                                     
REMARK   3                                                                      
REMARK   3  DEVIATIONS FROM IDEAL VALUES.                                       
REMARK   3                 RMSD          COUNT                                  
REMARK   3   BOND      :  0.003          46454                                  
REMARK   3   ANGLE     :  0.591          63537                                  
REMARK   3   CHIRALITY :  0.041           6858                                  
REMARK   3   PLANARITY :  0.005           8441                                  
REMARK   3   DIHEDRAL  :  4.552           6519                                  
REMARK   3                                                                      
REMARK   3  TLS DETAILS                                                         
REMARK   3   NUMBER OF TLS GROUPS  : NULL                                       
REMARK   3                                                                      
REMARK   3  NCS DETAILS                                                         
REMARK   3   NUMBER OF NCS GROUPS : NULL                                        
REMARK   3                                                                      
REMARK   3  OTHER REFINEMENT REMARKS: NULL                                      
REMARK   4                                                                      
REMARK   4 8BOZ COMPLIES WITH FORMAT V. 3.30, 13-JUL-11                         
REMARK 100                                                                      
REMARK 100 THIS ENTRY HAS BEEN PROCESSED BY PDBE ON 15-NOV-22.                  
REMARK 100 THE DEPOSITION ID IS D_1292126784.                                   
REMARK 200                                                                      
REMARK 200 EXPERIMENTAL DETAILS                                                 
REMARK 200  EXPERIMENT TYPE                : X-RAY DIFFRACTION                  
REMARK 200  DATE OF DATA COLLECTION        : 04-FEB-16                          
REMARK 200  TEMPERATURE           (KELVIN) : 100                                
REMARK 200  PH                             : 6.5                                
REMARK 200  NUMBER OF CRYSTALS USED        : 1                                  
REMARK 200                                                                      
REMARK 200  SYNCHROTRON              (Y/N) : Y                                  
REMARK 200  RADIATION SOURCE               : SOLEIL                             
REMARK 200  BEAMLINE                       : PROXIMA 2                          
REMARK 200  X-RAY GENERATOR MODEL          : NULL                               
REMARK 200  MONOCHROMATIC OR LAUE    (M/L) : M                                  
REMARK 200  WAVELENGTH OR RANGE        (A) : 0.9791                             
REMARK 200  MONOCHROMATOR                  : NULL                               
REMARK 200  OPTICS                         : NULL                               
REMARK 200                                                                      
REMARK 200  DETECTOR TYPE                  : PIXEL                              
REMARK 200  DETECTOR MANUFACTURER          : DECTRIS PILATUS 6M                 
REMARK 200  INTENSITY-INTEGRATION SOFTWARE : XDS                                
REMARK 200  DATA SCALING SOFTWARE          : XSCALE                             
REMARK 200                                                                      
REMARK 200  NUMBER OF UNIQUE REFLECTIONS   : 78970                              
REMARK 200  RESOLUTION RANGE HIGH      (A) : 3.600                              
REMARK 200  RESOLUTION RANGE LOW       (A) : 48.750                             
REMARK 200  REJECTION CRITERIA  (SIGMA(I)) : NULL                               
REMARK 200                                                                      
REMARK 200 OVERALL.                                                             
REMARK 200  COMPLETENESS FOR RANGE     (%) : 98.9                               
REMARK 200  DATA REDUNDANCY                : 3.900                              
REMARK 200  R MERGE                    (I) : NULL                               
REMARK 200  R SYM                      (I) : NULL                               
REMARK 200   FOR THE DATA SET  : 4.5000                             
REMARK 200                                                                      
REMARK 200 IN THE HIGHEST RESOLUTION SHELL.                                     
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE HIGH (A) : 3.60                     
REMARK 200  HIGHEST RESOLUTION SHELL, RANGE LOW  (A) : 3.64                     
REMARK 200  COMPLETENESS FOR SHELL     (%) : NULL                               
REMARK 200  DATA REDUNDANCY IN SHELL       : NULL                               
REMARK 200  R MERGE FOR SHELL          (I) : NULL                               
REMARK 200  R SYM FOR SHELL            (I) : NULL                               
REMARK 200   FOR SHELL         : NULL                               
REMARK 200                                                                      
REMARK 200 DIFFRACTION PROTOCOL: SINGLE WAVELENGTH                              
REMARK 200 METHOD USED TO DETERMINE THE STRUCTURE: MOLECULAR REPLACEMENT        
REMARK 200 SOFTWARE USED: MOLREP                                                
REMARK 200 STARTING MODEL: ALPHAFOLD MODEL                                      
REMARK 200                                                                      
REMARK 200 REMARK: NULL                                                         
REMARK 280                                                                      
REMARK 280 CRYSTAL                                                              
REMARK 280 SOLVENT CONTENT, VS   (%): 41.76                                     
REMARK 280 MATTHEWS COEFFICIENT, VM (ANGSTROMS**3/DA): 2.11                     
REMARK 280                                                                      
REMARK 280 CRYSTALLIZATION CONDITIONS: TLE3AIEC-TLI3AIEC CRYSTALS WERE          
REMARK 280  OBTAINED USING A RESERVOIR SOLUTION CONSISTING OF 20% V/V PEG       
REMARK 280  3350. BIS TRIS PROPANE PH 6.5, 0.2 M SODIUM ACETATE TRIHYDRATE      
REMARK 280  AFTER 44 DAYS AT 293 K., VAPOR DIFFUSION, SITTING DROP              
REMARK 290                                                                      
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY                                            
REMARK 290 SYMMETRY OPERATORS FOR SPACE GROUP: P 1 21 1                         
REMARK 290                                                                      
REMARK 290      SYMOP   SYMMETRY                                                
REMARK 290     NNNMMM   OPERATOR                                                
REMARK 290       1555   X,Y,Z                                                   
REMARK 290       2555   -X,Y+1/2,-Z                                             
REMARK 290                                                                      
REMARK 290     WHERE NNN -> OPERATOR NUMBER                                     
REMARK 290           MMM -> TRANSLATION VECTOR                                  
REMARK 290                                                                      
REMARK 290 CRYSTALLOGRAPHIC SYMMETRY TRANSFORMATIONS                            
REMARK 290 THE FOLLOWING TRANSFORMATIONS OPERATE ON THE ATOM/HETATM             
REMARK 290 RECORDS IN THIS ENTRY TO PRODUCE CRYSTALLOGRAPHICALLY                
REMARK 290 RELATED MOLECULES.                                                   
REMARK 290   SMTRY1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 290   SMTRY2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 290   SMTRY3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 290   SMTRY1   2 -1.000000  0.000000  0.000000        0.00000            
REMARK 290   SMTRY2   2  0.000000  1.000000  0.000000      224.53500            
REMARK 290   SMTRY3   2  0.000000  0.000000 -1.000000        0.00000            
REMARK 290                                                                      
REMARK 290 REMARK: NULL                                                         
REMARK 300                                                                      
REMARK 300 BIOMOLECULE: 1, 2, 3, 4, 5, 6, 7, 8                                  
REMARK 300 SEE REMARK 350 FOR THE AUTHOR PROVIDED AND/OR PROGRAM                
REMARK 300 GENERATED ASSEMBLY INFORMATION FOR THE STRUCTURE IN                  
REMARK 300 THIS ENTRY. THE REMARK MAY ALSO PROVIDE INFORMATION ON               
REMARK 300 BURIED SURFACE AREA.                                                 
REMARK 350                                                                      
REMARK 350 COORDINATES FOR A COMPLETE MULTIMER REPRESENTING THE KNOWN           
REMARK 350 BIOLOGICALLY SIGNIFICANT OLIGOMERIZATION STATE OF THE                
REMARK 350 MOLECULE CAN BE GENERATED BY APPLYING BIOMT TRANSFORMATIONS          
REMARK 350 GIVEN BELOW.  BOTH NON-CRYSTALLOGRAPHIC AND                          
REMARK 350 CRYSTALLOGRAPHIC OPERATIONS ARE GIVEN.                               
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 1                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: DIMERIC                           
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: DIMERIC                    
REMARK 350 SOFTWARE USED: PISA                                                  
REMARK 350 TOTAL BURIED SURFACE AREA: 3850 ANGSTROM**2                          
REMARK 350 SURFACE AREA OF THE COMPLEX: 30750 ANGSTROM**2                       
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -6.0 KCAL/MOL                         
REMARK 350 APPLY THE FOLLOWING TO CHAINS: A, B                                  
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 2                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: DIMERIC                           
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: DIMERIC                    
REMARK 350 SOFTWARE USED: PISA                                                  
REMARK 350 TOTAL BURIED SURFACE AREA: 3590 ANGSTROM**2                          
REMARK 350 SURFACE AREA OF THE COMPLEX: 29860 ANGSTROM**2                       
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -20.0 KCAL/MOL                        
REMARK 350 APPLY THE FOLLOWING TO CHAINS: C, D                                  
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 3                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: DIMERIC                           
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: DIMERIC                    
REMARK 350 SOFTWARE USED: PISA                                                  
REMARK 350 TOTAL BURIED SURFACE AREA: 3590 ANGSTROM**2                          
REMARK 350 SURFACE AREA OF THE COMPLEX: 31530 ANGSTROM**2                       
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -23.0 KCAL/MOL                        
REMARK 350 APPLY THE FOLLOWING TO CHAINS: E, F                                  
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 4                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: DIMERIC                           
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: DIMERIC                    
REMARK 350 SOFTWARE USED: PISA                                                  
REMARK 350 TOTAL BURIED SURFACE AREA: 3850 ANGSTROM**2                          
REMARK 350 SURFACE AREA OF THE COMPLEX: 31570 ANGSTROM**2                       
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -25.0 KCAL/MOL                        
REMARK 350 APPLY THE FOLLOWING TO CHAINS: G, H                                  
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 5                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: DIMERIC                           
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: DIMERIC                    
REMARK 350 SOFTWARE USED: PISA                                                  
REMARK 350 TOTAL BURIED SURFACE AREA: 3750 ANGSTROM**2                          
REMARK 350 SURFACE AREA OF THE COMPLEX: 31060 ANGSTROM**2                       
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -25.0 KCAL/MOL                        
REMARK 350 APPLY THE FOLLOWING TO CHAINS: I, J                                  
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 6                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: DIMERIC                           
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: DIMERIC                    
REMARK 350 SOFTWARE USED: PISA                                                  
REMARK 350 TOTAL BURIED SURFACE AREA: 3990 ANGSTROM**2                          
REMARK 350 SURFACE AREA OF THE COMPLEX: 30360 ANGSTROM**2                       
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -25.0 KCAL/MOL                        
REMARK 350 APPLY THE FOLLOWING TO CHAINS: K, L                                  
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 7                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: DIMERIC                           
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: DIMERIC                    
REMARK 350 SOFTWARE USED: PISA                                                  
REMARK 350 TOTAL BURIED SURFACE AREA: 3440 ANGSTROM**2                          
REMARK 350 SURFACE AREA OF THE COMPLEX: 30200 ANGSTROM**2                       
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -23.0 KCAL/MOL                        
REMARK 350 APPLY THE FOLLOWING TO CHAINS: M, N                                  
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 350                                                                      
REMARK 350 BIOMOLECULE: 8                                                       
REMARK 350 AUTHOR DETERMINED BIOLOGICAL UNIT: DIMERIC                           
REMARK 350 SOFTWARE DETERMINED QUATERNARY STRUCTURE: DIMERIC                    
REMARK 350 SOFTWARE USED: PISA                                                  
REMARK 350 TOTAL BURIED SURFACE AREA: 3610 ANGSTROM**2                          
REMARK 350 SURFACE AREA OF THE COMPLEX: 30590 ANGSTROM**2                       
REMARK 350 CHANGE IN SOLVENT FREE ENERGY: -20.0 KCAL/MOL                        
REMARK 350 APPLY THE FOLLOWING TO CHAINS: O, P                                  
REMARK 350   BIOMT1   1  1.000000  0.000000  0.000000        0.00000            
REMARK 350   BIOMT2   1  0.000000  1.000000  0.000000        0.00000            
REMARK 350   BIOMT3   1  0.000000  0.000000  1.000000        0.00000            
REMARK 465                                                                      
REMARK 465 MISSING RESIDUES                                                     
REMARK 465 THE FOLLOWING RESIDUES WERE NOT LOCATED IN THE                       
REMARK 465 EXPERIMENT. (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN               
REMARK 465 IDENTIFIER; SSSEQ=SEQUENCE NUMBER; I=INSERTION CODE.)                
REMARK 465                                                                      
REMARK 465   M RES C SSSEQI                                                     
REMARK 465     MET A     1                                                      
REMARK 465     SER A     2                                                      
REMARK 465     THR A     3                                                      
REMARK 465     ASN A     4                                                      
REMARK 465     LYS A     5                                                      
REMARK 465     SER A     6                                                      
REMARK 465     GLU A     7                                                      
REMARK 465     PRO A     8                                                      
REMARK 465     THR A     9                                                      
REMARK 465     ARG A    10                                                      
REMARK 465     LYS A    11                                                      
REMARK 465     VAL A    12                                                      
REMARK 465     ASP A    13                                                      
REMARK 465     VAL A    14                                                      
REMARK 465     HIS A    15                                                      
REMARK 465     LEU A    16                                                      
REMARK 465     THR A    17                                                      
REMARK 465     ASP A    18                                                      
REMARK 465     ASN A    19                                                      
REMARK 465     GLY A    20                                                      
REMARK 465     THR A    21                                                      
REMARK 465     PRO A    22                                                      
REMARK 465     PHE A    23                                                      
REMARK 465     ALA A    24                                                      
REMARK 465     TYR A    25                                                      
REMARK 465     SER A    26                                                      
REMARK 465     MET A    27                                                      
REMARK 465     THR A    28                                                      
REMARK 465     SER A    29                                                      
REMARK 465     HIS A    30                                                      
REMARK 465     LYS A    31                                                      
REMARK 465     ASN A    32                                                      
REMARK 465     VAL A    33                                                      
REMARK 465     LYS A    34                                                      
REMARK 465     VAL A    35                                                      
REMARK 465     ARG A    36                                                      
REMARK 465     ALA A    37                                                      
REMARK 465     ASN A    97                                                      
REMARK 465     SER A    98                                                      
REMARK 465     ASP A    99                                                      
REMARK 465     LYS A   100                                                      
REMARK 465     SER A   101                                                      
REMARK 465     GLU A   102                                                      
REMARK 465     GLY A   103                                                      
REMARK 465     GLY A   104                                                      
REMARK 465     TRP A   105                                                      
REMARK 465     GLU A   106                                                      
REMARK 465     HIS A   107                                                      
REMARK 465     THR A   108                                                      
REMARK 465     TYR A   109                                                      
REMARK 465     GLU A   110                                                      
REMARK 465     ILE A   111                                                      
REMARK 465     GLU A   112                                                      
REMARK 465     GLY A   113                                                      
REMARK 465     SER A   114                                                      
REMARK 465     GLN A   115                                                      
REMARK 465     SER A   206                                                      
REMARK 465     LEU A   207                                                      
REMARK 465     LEU A   208                                                      
REMARK 465     GLY A   209                                                      
REMARK 465     GLY A   221                                                      
REMARK 465     GLU A   222                                                      
REMARK 465     GLN A   333                                                      
REMARK 465     GLN A   334                                                      
REMARK 465     GLY A   335                                                      
REMARK 465     CYS A   336                                                      
REMARK 465     ASP A   337                                                      
REMARK 465     ASN A   338                                                      
REMARK 465     LEU A   339                                                      
REMARK 465     LEU A   340                                                      
REMARK 465     ALA A   341                                                      
REMARK 465     GLY A   342                                                      
REMARK 465     MET A   343                                                      
REMARK 465     SER A   344                                                      
REMARK 465     SER A   345                                                      
REMARK 465     ASP A   346                                                      
REMARK 465     GLY A   347                                                      
REMARK 465     ASN A   348                                                      
REMARK 465     SER A   349                                                      
REMARK 465     LEU A   522                                                      
REMARK 465     TYR A   523                                                      
REMARK 465     GLY A   524                                                      
REMARK 465     TYR A   525                                                      
REMARK 465     PHE A   526                                                      
REMARK 465     ASP A   527                                                      
REMARK 465     ARG A   528                                                      
REMARK 465     LYS A   529                                                      
REMARK 465     MET A   530                                                      
REMARK 465     VAL A   531                                                      
REMARK 465     PRO A   532                                                      
REMARK 465     LYS A   533                                                      
REMARK 465     LYS A   534                                                      
REMARK 465     ASP A   535                                                      
REMARK 465     SER A   536                                                      
REMARK 465     GLY A   537                                                      
REMARK 465     TYR A   538                                                      
REMARK 465     TYR A   539                                                      
REMARK 465     GLN A   540                                                      
REMARK 465     SER A   541                                                      
REMARK 465     GLY A   542                                                      
REMARK 465     PRO A   543                                                      
REMARK 465     GLY A   544                                                      
REMARK 465     SER A   545                                                      
REMARK 465     LYS A   546                                                      
REMARK 465     GLU A   547                                                      
REMARK 465     ASP A   548                                                      
REMARK 465     ARG A   549                                                      
REMARK 465     VAL A   550                                                      
REMARK 465     LYS A   551                                                      
REMARK 465     TYR A   552                                                      
REMARK 465     GLU A   553                                                      
REMARK 465     LYS A   554                                                      
REMARK 465     GLN A   555                                                      
REMARK 465     SER A   556                                                      
REMARK 465     GLN A   557                                                      
REMARK 465     ASN A   657                                                      
REMARK 465     VAL A   658                                                      
REMARK 465     MET C     1                                                      
REMARK 465     SER C     2                                                      
REMARK 465     THR C     3                                                      
REMARK 465     ASN C     4                                                      
REMARK 465     LYS C     5                                                      
REMARK 465     SER C     6                                                      
REMARK 465     GLU C     7                                                      
REMARK 465     PRO C     8                                                      
REMARK 465     THR C     9                                                      
REMARK 465     ARG C    10                                                      
REMARK 465     LYS C    11                                                      
REMARK 465     VAL C    12                                                      
REMARK 465     ASP C    13                                                      
REMARK 465     VAL C    14                                                      
REMARK 465     HIS C    15                                                      
REMARK 465     LEU C    16                                                      
REMARK 465     THR C    17                                                      
REMARK 465     ASP C    18                                                      
REMARK 465     ASN C    19                                                      
REMARK 465     GLY C    20                                                      
REMARK 465     THR C    21                                                      
REMARK 465     PRO C    22                                                      
REMARK 465     PHE C    23                                                      
REMARK 465     ALA C    24                                                      
REMARK 465     TYR C    25                                                      
REMARK 465     SER C    26                                                      
REMARK 465     MET C    27                                                      
REMARK 465     THR C    28                                                      
REMARK 465     SER C    29                                                      
REMARK 465     HIS C    30                                                      
REMARK 465     LYS C    31                                                      
REMARK 465     ASN C    32                                                      
REMARK 465     VAL C    33                                                      
REMARK 465     LYS C    34                                                      
REMARK 465     VAL C    35                                                      
REMARK 465     ARG C    36                                                      
REMARK 465     ALA C    37                                                      
REMARK 465     GLU C    38                                                      
REMARK 465     VAL C    39                                                      
REMARK 465     GLN C    40                                                      
REMARK 465     ASN C    97                                                      
REMARK 465     SER C    98                                                      
REMARK 465     ASP C    99                                                      
REMARK 465     LYS C   100                                                      
REMARK 465     SER C   101                                                      
REMARK 465     GLU C   102                                                      
REMARK 465     GLY C   103                                                      
REMARK 465     GLY C   104                                                      
REMARK 465     TRP C   105                                                      
REMARK 465     GLU C   106                                                      
REMARK 465     HIS C   107                                                      
REMARK 465     THR C   108                                                      
REMARK 465     TYR C   109                                                      
REMARK 465     GLU C   110                                                      
REMARK 465     ILE C   111                                                      
REMARK 465     GLU C   112                                                      
REMARK 465     GLY C   113                                                      
REMARK 465     SER C   114                                                      
REMARK 465     GLN C   115                                                      
REMARK 465     ASN C   204                                                      
REMARK 465     PRO C   205                                                      
REMARK 465     SER C   206                                                      
REMARK 465     LEU C   207                                                      
REMARK 465     LEU C   208                                                      
REMARK 465     GLY C   209                                                      
REMARK 465     GLY C   221                                                      
REMARK 465     GLU C   222                                                      
REMARK 465     ARG C   223                                                      
REMARK 465     ARG C   330                                                      
REMARK 465     LEU C   331                                                      
REMARK 465     LYS C   332                                                      
REMARK 465     GLN C   333                                                      
REMARK 465     GLN C   334                                                      
REMARK 465     GLY C   335                                                      
REMARK 465     CYS C   336                                                      
REMARK 465     ASP C   337                                                      
REMARK 465     ASN C   338                                                      
REMARK 465     LEU C   339                                                      
REMARK 465     LEU C   340                                                      
REMARK 465     ALA C   341                                                      
REMARK 465     GLY C   342                                                      
REMARK 465     MET C   343                                                      
REMARK 465     SER C   344                                                      
REMARK 465     SER C   345                                                      
REMARK 465     ASP C   346                                                      
REMARK 465     GLY C   347                                                      
REMARK 465     ASN C   348                                                      
REMARK 465     SER C   349                                                      
REMARK 465     TYR C   523                                                      
REMARK 465     GLY C   524                                                      
REMARK 465     TYR C   525                                                      
REMARK 465     PHE C   526                                                      
REMARK 465     ASP C   527                                                      
REMARK 465     ARG C   528                                                      
REMARK 465     LYS C   529                                                      
REMARK 465     MET C   530                                                      
REMARK 465     VAL C   531                                                      
REMARK 465     PRO C   532                                                      
REMARK 465     LYS C   533                                                      
REMARK 465     LYS C   534                                                      
REMARK 465     ASP C   535                                                      
REMARK 465     SER C   536                                                      
REMARK 465     GLY C   537                                                      
REMARK 465     TYR C   538                                                      
REMARK 465     TYR C   539                                                      
REMARK 465     GLN C   540                                                      
REMARK 465     SER C   541                                                      
REMARK 465     GLY C   542                                                      
REMARK 465     PRO C   543                                                      
REMARK 465     GLY C   544                                                      
REMARK 465     SER C   545                                                      
REMARK 465     LYS C   546                                                      
REMARK 465     GLU C   547                                                      
REMARK 465     ASP C   548                                                      
REMARK 465     ARG C   549                                                      
REMARK 465     VAL C   550                                                      
REMARK 465     LYS C   551                                                      
REMARK 465     TYR C   552                                                      
REMARK 465     GLU C   553                                                      
REMARK 465     LYS C   554                                                      
REMARK 465     GLN C   555                                                      
REMARK 465     SER C   556                                                      
REMARK 465     GLN C   557                                                      
REMARK 465     GLU C   558                                                      
REMARK 465     LEU C   655                                                      
REMARK 465     ARG C   656                                                      
REMARK 465     ASN C   657                                                      
REMARK 465     VAL C   658                                                      
REMARK 465     MET B     1                                                      
REMARK 465     LEU B     2                                                      
REMARK 465     LYS B     3                                                      
REMARK 465     GLU B     4                                                      
REMARK 465     TRP B     5                                                      
REMARK 465     MET B     6                                                      
REMARK 465     ILE B     7                                                      
REMARK 465     PHE B     8                                                      
REMARK 465     THR B     9                                                      
REMARK 465     CYS B    10                                                      
REMARK 465     SER B    11                                                      
REMARK 465     LEU B    12                                                      
REMARK 465     LEU B    13                                                      
REMARK 465     THR B    14                                                      
REMARK 465     LEU B    15                                                      
REMARK 465     ALA B    16                                                      
REMARK 465     GLY B    17                                                      
REMARK 465     ALA B    18                                                      
REMARK 465     SER B    19                                                      
REMARK 465     LEU B    20                                                      
REMARK 465     PRO B    21                                                      
REMARK 465     LEU B    22                                                      
REMARK 465     SER B    23                                                      
REMARK 465     GLY B    24                                                      
REMARK 465     CYS B    25                                                      
REMARK 465     ILE B    26                                                      
REMARK 465     SER B    27                                                      
REMARK 465     ARG B    28                                                      
REMARK 465     GLY B    29                                                      
REMARK 465     GLN B    30                                                      
REMARK 465     GLU B    31                                                      
REMARK 465     SER B    32                                                      
REMARK 465     ILE B    33                                                      
REMARK 465     SER B    34                                                      
REMARK 465     GLU B    35                                                      
REMARK 465     GLY B    36                                                      
REMARK 465     ALA B    37                                                      
REMARK 465     ALA B    38                                                      
REMARK 465     PHE B    39                                                      
REMARK 465     GLY B    40                                                      
REMARK 465     ALA B    41                                                      
REMARK 465     GLY B    42                                                      
REMARK 465     ILE B    43                                                      
REMARK 465     LEU B    44                                                      
REMARK 465     ARG B    45                                                      
REMARK 465     GLU B    46                                                      
REMARK 465     PRO B    47                                                      
REMARK 465     GLY B    48                                                      
REMARK 465     ALA B    49                                                      
REMARK 465     THR B    50                                                      
REMARK 465     LYS B    51                                                      
REMARK 465     LYS B    52                                                      
REMARK 465     ALA B    53                                                      
REMARK 465     ASP B    54                                                      
REMARK 465     THR B    55                                                      
REMARK 465     LYS B    56                                                      
REMARK 465     ASP B    57                                                      
REMARK 465     ILE B   273                                                      
REMARK 465     GLN B   274                                                      
REMARK 465     MET E     1                                                      
REMARK 465     SER E     2                                                      
REMARK 465     THR E     3                                                      
REMARK 465     ASN E     4                                                      
REMARK 465     LYS E     5                                                      
REMARK 465     SER E     6                                                      
REMARK 465     GLU E     7                                                      
REMARK 465     PRO E     8                                                      
REMARK 465     THR E     9                                                      
REMARK 465     ARG E    10                                                      
REMARK 465     LYS E    11                                                      
REMARK 465     VAL E    12                                                      
REMARK 465     ASP E    13                                                      
REMARK 465     VAL E    14                                                      
REMARK 465     HIS E    15                                                      
REMARK 465     LEU E    16                                                      
REMARK 465     THR E    17                                                      
REMARK 465     ASP E    18                                                      
REMARK 465     ASN E    19                                                      
REMARK 465     GLY E    20                                                      
REMARK 465     THR E    21                                                      
REMARK 465     PRO E    22                                                      
REMARK 465     PHE E    23                                                      
REMARK 465     ALA E    24                                                      
REMARK 465     TYR E    25                                                      
REMARK 465     SER E    26                                                      
REMARK 465     MET E    27                                                      
REMARK 465     THR E    28                                                      
REMARK 465     SER E    29                                                      
REMARK 465     HIS E    30                                                      
REMARK 465     LYS E    31                                                      
REMARK 465     ASN E    32                                                      
REMARK 465     VAL E    33                                                      
REMARK 465     LYS E    34                                                      
REMARK 465     VAL E    35                                                      
REMARK 465     ARG E    36                                                      
REMARK 465     ALA E    37                                                      
REMARK 465     GLU E    38                                                      
REMARK 465     VAL E    39                                                      
REMARK 465     ASN E    97                                                      
REMARK 465     SER E    98                                                      
REMARK 465     ASP E    99                                                      
REMARK 465     LYS E   100                                                      
REMARK 465     SER E   101                                                      
REMARK 465     GLU E   102                                                      
REMARK 465     GLY E   103                                                      
REMARK 465     GLY E   104                                                      
REMARK 465     TRP E   105                                                      
REMARK 465     GLU E   106                                                      
REMARK 465     HIS E   107                                                      
REMARK 465     THR E   108                                                      
REMARK 465     TYR E   109                                                      
REMARK 465     GLU E   110                                                      
REMARK 465     ILE E   111                                                      
REMARK 465     GLU E   112                                                      
REMARK 465     GLY E   113                                                      
REMARK 465     SER E   114                                                      
REMARK 465     GLN E   115                                                      
REMARK 465     PRO E   205                                                      
REMARK 465     SER E   206                                                      
REMARK 465     LEU E   207                                                      
REMARK 465     LYS E   332                                                      
REMARK 465     GLN E   333                                                      
REMARK 465     GLN E   334                                                      
REMARK 465     GLY E   335                                                      
REMARK 465     CYS E   336                                                      
REMARK 465     ASP E   337                                                      
REMARK 465     ASN E   338                                                      
REMARK 465     LEU E   339                                                      
REMARK 465     LEU E   340                                                      
REMARK 465     ALA E   341                                                      
REMARK 465     GLY E   342                                                      
REMARK 465     MET E   343                                                      
REMARK 465     SER E   344                                                      
REMARK 465     SER E   345                                                      
REMARK 465     ASP E   346                                                      
REMARK 465     GLY E   347                                                      
REMARK 465     PRO E   532                                                      
REMARK 465     LYS E   533                                                      
REMARK 465     LYS E   534                                                      
REMARK 465     ASP E   535                                                      
REMARK 465     SER E   536                                                      
REMARK 465     GLY E   537                                                      
REMARK 465     TYR E   538                                                      
REMARK 465     TYR E   539                                                      
REMARK 465     GLN E   540                                                      
REMARK 465     SER E   541                                                      
REMARK 465     GLY E   542                                                      
REMARK 465     PRO E   543                                                      
REMARK 465     GLY E   544                                                      
REMARK 465     SER E   545                                                      
REMARK 465     LYS E   546                                                      
REMARK 465     GLU E   547                                                      
REMARK 465     ASP E   548                                                      
REMARK 465     ARG E   549                                                      
REMARK 465     VAL E   550                                                      
REMARK 465     LYS E   551                                                      
REMARK 465     TYR E   552                                                      
REMARK 465     GLU E   553                                                      
REMARK 465     LYS E   554                                                      
REMARK 465     GLN E   555                                                      
REMARK 465     LEU E   655                                                      
REMARK 465     ARG E   656                                                      
REMARK 465     ASN E   657                                                      
REMARK 465     VAL E   658                                                      
REMARK 465     MET D     1                                                      
REMARK 465     LEU D     2                                                      
REMARK 465     LYS D     3                                                      
REMARK 465     GLU D     4                                                      
REMARK 465     TRP D     5                                                      
REMARK 465     MET D     6                                                      
REMARK 465     ILE D     7                                                      
REMARK 465     PHE D     8                                                      
REMARK 465     THR D     9                                                      
REMARK 465     CYS D    10                                                      
REMARK 465     SER D    11                                                      
REMARK 465     LEU D    12                                                      
REMARK 465     LEU D    13                                                      
REMARK 465     THR D    14                                                      
REMARK 465     LEU D    15                                                      
REMARK 465     ALA D    16                                                      
REMARK 465     GLY D    17                                                      
REMARK 465     ALA D    18                                                      
REMARK 465     SER D    19                                                      
REMARK 465     LEU D    20                                                      
REMARK 465     PRO D    21                                                      
REMARK 465     LEU D    22                                                      
REMARK 465     SER D    23                                                      
REMARK 465     GLY D    24                                                      
REMARK 465     CYS D    25                                                      
REMARK 465     ILE D    26                                                      
REMARK 465     SER D    27                                                      
REMARK 465     ARG D    28                                                      
REMARK 465     GLY D    29                                                      
REMARK 465     GLN D    30                                                      
REMARK 465     GLU D    31                                                      
REMARK 465     SER D    32                                                      
REMARK 465     ILE D    33                                                      
REMARK 465     SER D    34                                                      
REMARK 465     GLU D    35                                                      
REMARK 465     GLY D    36                                                      
REMARK 465     ALA D    37                                                      
REMARK 465     ALA D    38                                                      
REMARK 465     PHE D    39                                                      
REMARK 465     GLY D    40                                                      
REMARK 465     ALA D    41                                                      
REMARK 465     GLY D    42                                                      
REMARK 465     ILE D    43                                                      
REMARK 465     LEU D    44                                                      
REMARK 465     ARG D    45                                                      
REMARK 465     GLU D    46                                                      
REMARK 465     PRO D    47                                                      
REMARK 465     GLY D    48                                                      
REMARK 465     ALA D    49                                                      
REMARK 465     THR D    50                                                      
REMARK 465     LYS D    51                                                      
REMARK 465     LYS D    52                                                      
REMARK 465     ALA D    53                                                      
REMARK 465     ASP D    54                                                      
REMARK 465     THR D    55                                                      
REMARK 465     LYS D    56                                                      
REMARK 465     ASP D    57                                                      
REMARK 465     LEU D    58                                                      
REMARK 465     SER D   269                                                      
REMARK 465     GLU D   270                                                      
REMARK 465     SER D   271                                                      
REMARK 465     LYS D   272                                                      
REMARK 465     ILE D   273                                                      
REMARK 465     GLN D   274                                                      
REMARK 465     MET F     1                                                      
REMARK 465     LEU F     2                                                      
REMARK 465     LYS F     3                                                      
REMARK 465     GLU F     4                                                      
REMARK 465     TRP F     5                                                      
REMARK 465     MET F     6                                                      
REMARK 465     ILE F     7                                                      
REMARK 465     PHE F     8                                                      
REMARK 465     THR F     9                                                      
REMARK 465     CYS F    10                                                      
REMARK 465     SER F    11                                                      
REMARK 465     LEU F    12                                                      
REMARK 465     LEU F    13                                                      
REMARK 465     THR F    14                                                      
REMARK 465     LEU F    15                                                      
REMARK 465     ALA F    16                                                      
REMARK 465     GLY F    17                                                      
REMARK 465     ALA F    18                                                      
REMARK 465     SER F    19                                                      
REMARK 465     LEU F    20                                                      
REMARK 465     PRO F    21                                                      
REMARK 465     LEU F    22                                                      
REMARK 465     SER F    23                                                      
REMARK 465     GLY F    24                                                      
REMARK 465     CYS F    25                                                      
REMARK 465     ILE F    26                                                      
REMARK 465     SER F    27                                                      
REMARK 465     ARG F    28                                                      
REMARK 465     GLY F    29                                                      
REMARK 465     GLN F    30                                                      
REMARK 465     GLU F    31                                                      
REMARK 465     SER F    32                                                      
REMARK 465     ILE F    33                                                      
REMARK 465     SER F    34                                                      
REMARK 465     GLU F    35                                                      
REMARK 465     GLY F    36                                                      
REMARK 465     ALA F    37                                                      
REMARK 465     ALA F    38                                                      
REMARK 465     PHE F    39                                                      
REMARK 465     GLY F    40                                                      
REMARK 465     ALA F    41                                                      
REMARK 465     GLY F    42                                                      
REMARK 465     ILE F    43                                                      
REMARK 465     LEU F    44                                                      
REMARK 465     ARG F    45                                                      
REMARK 465     GLU F    46                                                      
REMARK 465     PRO F    47                                                      
REMARK 465     GLY F    48                                                      
REMARK 465     ALA F    49                                                      
REMARK 465     THR F    50                                                      
REMARK 465     LYS F    51                                                      
REMARK 465     LYS F    52                                                      
REMARK 465     ALA F    53                                                      
REMARK 465     ASP F    54                                                      
REMARK 465     THR F    55                                                      
REMARK 465     LYS F    56                                                      
REMARK 465     ASP F    57                                                      
REMARK 465     SER F   271                                                      
REMARK 465     LYS F   272                                                      
REMARK 465     ILE F   273                                                      
REMARK 465     GLN F   274                                                      
REMARK 465     MET G     1                                                      
REMARK 465     SER G     2                                                      
REMARK 465     THR G     3                                                      
REMARK 465     ASN G     4                                                      
REMARK 465     LYS G     5                                                      
REMARK 465     SER G     6                                                      
REMARK 465     GLU G     7                                                      
REMARK 465     PRO G     8                                                      
REMARK 465     THR G     9                                                      
REMARK 465     ARG G    10                                                      
REMARK 465     LYS G    11                                                      
REMARK 465     VAL G    12                                                      
REMARK 465     ASP G    13                                                      
REMARK 465     VAL G    14                                                      
REMARK 465     HIS G    15                                                      
REMARK 465     LEU G    16                                                      
REMARK 465     THR G    17                                                      
REMARK 465     ASP G    18                                                      
REMARK 465     ASN G    19                                                      
REMARK 465     GLY G    20                                                      
REMARK 465     THR G    21                                                      
REMARK 465     PRO G    22                                                      
REMARK 465     PHE G    23                                                      
REMARK 465     ALA G    24                                                      
REMARK 465     TYR G    25                                                      
REMARK 465     SER G    26                                                      
REMARK 465     MET G    27                                                      
REMARK 465     THR G    28                                                      
REMARK 465     SER G    29                                                      
REMARK 465     HIS G    30                                                      
REMARK 465     LYS G    31                                                      
REMARK 465     ASN G    32                                                      
REMARK 465     VAL G    33                                                      
REMARK 465     LYS G    34                                                      
REMARK 465     VAL G    35                                                      
REMARK 465     ARG G    36                                                      
REMARK 465     ALA G    37                                                      
REMARK 465     GLU G    38                                                      
REMARK 465     ASN G    97                                                      
REMARK 465     SER G    98                                                      
REMARK 465     ASP G    99                                                      
REMARK 465     LYS G   100                                                      
REMARK 465     SER G   101                                                      
REMARK 465     GLU G   102                                                      
REMARK 465     GLY G   103                                                      
REMARK 465     GLY G   104                                                      
REMARK 465     TRP G   105                                                      
REMARK 465     GLU G   106                                                      
REMARK 465     HIS G   107                                                      
REMARK 465     THR G   108                                                      
REMARK 465     TYR G   109                                                      
REMARK 465     GLU G   110                                                      
REMARK 465     ILE G   111                                                      
REMARK 465     GLU G   112                                                      
REMARK 465     GLY G   113                                                      
REMARK 465     SER G   114                                                      
REMARK 465     GLN G   115                                                      
REMARK 465     ASN G   204                                                      
REMARK 465     PRO G   205                                                      
REMARK 465     SER G   206                                                      
REMARK 465     LEU G   207                                                      
REMARK 465     LEU G   208                                                      
REMARK 465     GLY G   209                                                      
REMARK 465     GLY G   335                                                      
REMARK 465     CYS G   336                                                      
REMARK 465     ASP G   337                                                      
REMARK 465     ASN G   338                                                      
REMARK 465     LEU G   339                                                      
REMARK 465     LEU G   340                                                      
REMARK 465     ALA G   341                                                      
REMARK 465     GLY G   342                                                      
REMARK 465     MET G   343                                                      
REMARK 465     SER G   344                                                      
REMARK 465     SER G   345                                                      
REMARK 465     ASP G   346                                                      
REMARK 465     GLY G   347                                                      
REMARK 465     LYS G   534                                                      
REMARK 465     ASP G   535                                                      
REMARK 465     SER G   536                                                      
REMARK 465     GLY G   537                                                      
REMARK 465     TYR G   538                                                      
REMARK 465     TYR G   539                                                      
REMARK 465     GLN G   540                                                      
REMARK 465     SER G   541                                                      
REMARK 465     GLY G   542                                                      
REMARK 465     PRO G   543                                                      
REMARK 465     GLY G   544                                                      
REMARK 465     SER G   545                                                      
REMARK 465     LYS G   546                                                      
REMARK 465     GLU G   547                                                      
REMARK 465     ASP G   548                                                      
REMARK 465     ARG G   549                                                      
REMARK 465     VAL G   550                                                      
REMARK 465     LYS G   551                                                      
REMARK 465     TYR G   552                                                      
REMARK 465     ARG G   654                                                      
REMARK 465     LEU G   655                                                      
REMARK 465     ARG G   656                                                      
REMARK 465     ASN G   657                                                      
REMARK 465     VAL G   658                                                      
REMARK 465     MET H     1                                                      
REMARK 465     LEU H     2                                                      
REMARK 465     LYS H     3                                                      
REMARK 465     GLU H     4                                                      
REMARK 465     TRP H     5                                                      
REMARK 465     MET H     6                                                      
REMARK 465     ILE H     7                                                      
REMARK 465     PHE H     8                                                      
REMARK 465     THR H     9                                                      
REMARK 465     CYS H    10                                                      
REMARK 465     SER H    11                                                      
REMARK 465     LEU H    12                                                      
REMARK 465     LEU H    13                                                      
REMARK 465     THR H    14                                                      
REMARK 465     LEU H    15                                                      
REMARK 465     ALA H    16                                                      
REMARK 465     GLY H    17                                                      
REMARK 465     ALA H    18                                                      
REMARK 465     SER H    19                                                      
REMARK 465     LEU H    20                                                      
REMARK 465     PRO H    21                                                      
REMARK 465     LEU H    22                                                      
REMARK 465     SER H    23                                                      
REMARK 465     GLY H    24                                                      
REMARK 465     CYS H    25                                                      
REMARK 465     ILE H    26                                                      
REMARK 465     SER H    27                                                      
REMARK 465     ARG H    28                                                      
REMARK 465     GLY H    29                                                      
REMARK 465     GLN H    30                                                      
REMARK 465     GLU H    31                                                      
REMARK 465     SER H    32                                                      
REMARK 465     ILE H    33                                                      
REMARK 465     SER H    34                                                      
REMARK 465     GLU H    35                                                      
REMARK 465     GLY H    36                                                      
REMARK 465     ALA H    37                                                      
REMARK 465     ALA H    38                                                      
REMARK 465     PHE H    39                                                      
REMARK 465     GLY H    40                                                      
REMARK 465     ALA H    41                                                      
REMARK 465     GLY H    42                                                      
REMARK 465     ILE H    43                                                      
REMARK 465     LEU H    44                                                      
REMARK 465     ARG H    45                                                      
REMARK 465     GLU H    46                                                      
REMARK 465     PRO H    47                                                      
REMARK 465     GLY H    48                                                      
REMARK 465     ALA H    49                                                      
REMARK 465     THR H    50                                                      
REMARK 465     LYS H    51                                                      
REMARK 465     LYS H    52                                                      
REMARK 465     ALA H    53                                                      
REMARK 465     ASP H    54                                                      
REMARK 465     THR H    55                                                      
REMARK 465     LYS H    56                                                      
REMARK 465     ASP H    57                                                      
REMARK 465     LEU H    58                                                      
REMARK 465     GLU H   270                                                      
REMARK 465     SER H   271                                                      
REMARK 465     LYS H   272                                                      
REMARK 465     ILE H   273                                                      
REMARK 465     GLN H   274                                                      
REMARK 465     MET I     1                                                      
REMARK 465     SER I     2                                                      
REMARK 465     THR I     3                                                      
REMARK 465     ASN I     4                                                      
REMARK 465     LYS I     5                                                      
REMARK 465     SER I     6                                                      
REMARK 465     GLU I     7                                                      
REMARK 465     PRO I     8                                                      
REMARK 465     THR I     9                                                      
REMARK 465     ARG I    10                                                      
REMARK 465     LYS I    11                                                      
REMARK 465     VAL I    12                                                      
REMARK 465     ASP I    13                                                      
REMARK 465     VAL I    14                                                      
REMARK 465     HIS I    15                                                      
REMARK 465     LEU I    16                                                      
REMARK 465     THR I    17                                                      
REMARK 465     ASP I    18                                                      
REMARK 465     ASN I    19                                                      
REMARK 465     GLY I    20                                                      
REMARK 465     THR I    21                                                      
REMARK 465     PRO I    22                                                      
REMARK 465     PHE I    23                                                      
REMARK 465     ALA I    24                                                      
REMARK 465     TYR I    25                                                      
REMARK 465     SER I    26                                                      
REMARK 465     MET I    27                                                      
REMARK 465     THR I    28                                                      
REMARK 465     SER I    29                                                      
REMARK 465     HIS I    30                                                      
REMARK 465     LYS I    31                                                      
REMARK 465     ASN I    32                                                      
REMARK 465     VAL I    33                                                      
REMARK 465     LYS I    34                                                      
REMARK 465     VAL I    35                                                      
REMARK 465     ARG I    36                                                      
REMARK 465     ALA I    37                                                      
REMARK 465     GLU I    38                                                      
REMARK 465     ASN I    97                                                      
REMARK 465     SER I    98                                                      
REMARK 465     ASP I    99                                                      
REMARK 465     LYS I   100                                                      
REMARK 465     SER I   101                                                      
REMARK 465     GLU I   102                                                      
REMARK 465     GLY I   103                                                      
REMARK 465     GLY I   104                                                      
REMARK 465     TRP I   105                                                      
REMARK 465     GLU I   106                                                      
REMARK 465     HIS I   107                                                      
REMARK 465     THR I   108                                                      
REMARK 465     TYR I   109                                                      
REMARK 465     GLU I   110                                                      
REMARK 465     ILE I   111                                                      
REMARK 465     GLU I   112                                                      
REMARK 465     GLY I   113                                                      
REMARK 465     SER I   114                                                      
REMARK 465     GLN I   115                                                      
REMARK 465     ASN I   204                                                      
REMARK 465     PRO I   205                                                      
REMARK 465     SER I   206                                                      
REMARK 465     LEU I   207                                                      
REMARK 465     GLY I   221                                                      
REMARK 465     GLU I   222                                                      
REMARK 465     ARG I   223                                                      
REMARK 465     ARG I   330                                                      
REMARK 465     LEU I   331                                                      
REMARK 465     LYS I   332                                                      
REMARK 465     GLN I   333                                                      
REMARK 465     GLN I   334                                                      
REMARK 465     GLY I   335                                                      
REMARK 465     CYS I   336                                                      
REMARK 465     ASP I   337                                                      
REMARK 465     ASN I   338                                                      
REMARK 465     LEU I   339                                                      
REMARK 465     LEU I   340                                                      
REMARK 465     ALA I   341                                                      
REMARK 465     GLY I   342                                                      
REMARK 465     MET I   343                                                      
REMARK 465     SER I   344                                                      
REMARK 465     SER I   345                                                      
REMARK 465     ASP I   346                                                      
REMARK 465     GLY I   347                                                      
REMARK 465     ASN I   348                                                      
REMARK 465     LEU I   522                                                      
REMARK 465     TYR I   523                                                      
REMARK 465     GLY I   524                                                      
REMARK 465     TYR I   525                                                      
REMARK 465     PHE I   526                                                      
REMARK 465     ASP I   527                                                      
REMARK 465     ARG I   528                                                      
REMARK 465     LYS I   529                                                      
REMARK 465     MET I   530                                                      
REMARK 465     VAL I   531                                                      
REMARK 465     PRO I   532                                                      
REMARK 465     LYS I   533                                                      
REMARK 465     LYS I   534                                                      
REMARK 465     ASP I   535                                                      
REMARK 465     SER I   536                                                      
REMARK 465     GLY I   537                                                      
REMARK 465     TYR I   538                                                      
REMARK 465     TYR I   539                                                      
REMARK 465     GLN I   540                                                      
REMARK 465     SER I   541                                                      
REMARK 465     GLY I   542                                                      
REMARK 465     PRO I   543                                                      
REMARK 465     GLY I   544                                                      
REMARK 465     SER I   545                                                      
REMARK 465     LYS I   546                                                      
REMARK 465     GLU I   547                                                      
REMARK 465     ASP I   548                                                      
REMARK 465     ARG I   549                                                      
REMARK 465     VAL I   550                                                      
REMARK 465     LYS I   551                                                      
REMARK 465     ASN I   657                                                      
REMARK 465     VAL I   658                                                      
REMARK 465     MET J     1                                                      
REMARK 465     LEU J     2                                                      
REMARK 465     LYS J     3                                                      
REMARK 465     GLU J     4                                                      
REMARK 465     TRP J     5                                                      
REMARK 465     MET J     6                                                      
REMARK 465     ILE J     7                                                      
REMARK 465     PHE J     8                                                      
REMARK 465     THR J     9                                                      
REMARK 465     CYS J    10                                                      
REMARK 465     SER J    11                                                      
REMARK 465     LEU J    12                                                      
REMARK 465     LEU J    13                                                      
REMARK 465     THR J    14                                                      
REMARK 465     LEU J    15                                                      
REMARK 465     ALA J    16                                                      
REMARK 465     GLY J    17                                                      
REMARK 465     ALA J    18                                                      
REMARK 465     SER J    19                                                      
REMARK 465     LEU J    20                                                      
REMARK 465     PRO J    21                                                      
REMARK 465     LEU J    22                                                      
REMARK 465     SER J    23                                                      
REMARK 465     GLY J    24                                                      
REMARK 465     CYS J    25                                                      
REMARK 465     ILE J    26                                                      
REMARK 465     SER J    27                                                      
REMARK 465     ARG J    28                                                      
REMARK 465     GLY J    29                                                      
REMARK 465     GLN J    30                                                      
REMARK 465     GLU J    31                                                      
REMARK 465     SER J    32                                                      
REMARK 465     ILE J    33                                                      
REMARK 465     SER J    34                                                      
REMARK 465     GLU J    35                                                      
REMARK 465     GLY J    36                                                      
REMARK 465     ALA J    37                                                      
REMARK 465     ALA J    38                                                      
REMARK 465     PHE J    39                                                      
REMARK 465     GLY J    40                                                      
REMARK 465     ALA J    41                                                      
REMARK 465     GLY J    42                                                      
REMARK 465     ILE J    43                                                      
REMARK 465     LEU J    44                                                      
REMARK 465     ARG J    45                                                      
REMARK 465     GLU J    46                                                      
REMARK 465     PRO J    47                                                      
REMARK 465     GLY J    48                                                      
REMARK 465     ALA J    49                                                      
REMARK 465     THR J    50                                                      
REMARK 465     LYS J    51                                                      
REMARK 465     LYS J    52                                                      
REMARK 465     ALA J    53                                                      
REMARK 465     ASP J    54                                                      
REMARK 465     THR J    55                                                      
REMARK 465     LYS J    56                                                      
REMARK 465     ASP J    57                                                      
REMARK 465     LEU J    58                                                      
REMARK 465     MET K     1                                                      
REMARK 465     SER K     2                                                      
REMARK 465     THR K     3                                                      
REMARK 465     ASN K     4                                                      
REMARK 465     LYS K     5                                                      
REMARK 465     SER K     6                                                      
REMARK 465     GLU K     7                                                      
REMARK 465     PRO K     8                                                      
REMARK 465     THR K     9                                                      
REMARK 465     ARG K    10                                                      
REMARK 465     LYS K    11                                                      
REMARK 465     VAL K    12                                                      
REMARK 465     ASP K    13                                                      
REMARK 465     VAL K    14                                                      
REMARK 465     HIS K    15                                                      
REMARK 465     LEU K    16                                                      
REMARK 465     THR K    17                                                      
REMARK 465     ASP K    18                                                      
REMARK 465     ASN K    19                                                      
REMARK 465     GLY K    20                                                      
REMARK 465     THR K    21                                                      
REMARK 465     PRO K    22                                                      
REMARK 465     PHE K    23                                                      
REMARK 465     ALA K    24                                                      
REMARK 465     TYR K    25                                                      
REMARK 465     SER K    26                                                      
REMARK 465     MET K    27                                                      
REMARK 465     THR K    28                                                      
REMARK 465     SER K    29                                                      
REMARK 465     HIS K    30                                                      
REMARK 465     LYS K    31                                                      
REMARK 465     ASN K    32                                                      
REMARK 465     VAL K    33                                                      
REMARK 465     LYS K    34                                                      
REMARK 465     VAL K    35                                                      
REMARK 465     ARG K    36                                                      
REMARK 465     ALA K    37                                                      
REMARK 465     ASN K    97                                                      
REMARK 465     SER K    98                                                      
REMARK 465     ASP K    99                                                      
REMARK 465     LYS K   100                                                      
REMARK 465     SER K   101                                                      
REMARK 465     GLU K   102                                                      
REMARK 465     GLY K   103                                                      
REMARK 465     GLY K   104                                                      
REMARK 465     TRP K   105                                                      
REMARK 465     GLU K   106                                                      
REMARK 465     HIS K   107                                                      
REMARK 465     THR K   108                                                      
REMARK 465     TYR K   109                                                      
REMARK 465     GLU K   110                                                      
REMARK 465     ILE K   111                                                      
REMARK 465     GLU K   112                                                      
REMARK 465     GLY K   113                                                      
REMARK 465     SER K   114                                                      
REMARK 465     GLN K   115                                                      
REMARK 465     ASN K   204                                                      
REMARK 465     PRO K   205                                                      
REMARK 465     SER K   206                                                      
REMARK 465     LEU K   207                                                      
REMARK 465     LEU K   208                                                      
REMARK 465     GLY K   209                                                      
REMARK 465     GLY K   221                                                      
REMARK 465     GLU K   222                                                      
REMARK 465     ARG K   223                                                      
REMARK 465     ASP K   337                                                      
REMARK 465     ASN K   338                                                      
REMARK 465     LEU K   339                                                      
REMARK 465     LEU K   340                                                      
REMARK 465     ALA K   341                                                      
REMARK 465     GLY K   342                                                      
REMARK 465     MET K   343                                                      
REMARK 465     SER K   344                                                      
REMARK 465     LEU K   522                                                      
REMARK 465     TYR K   523                                                      
REMARK 465     GLY K   524                                                      
REMARK 465     TYR K   525                                                      
REMARK 465     PHE K   526                                                      
REMARK 465     ASP K   527                                                      
REMARK 465     ARG K   528                                                      
REMARK 465     LYS K   529                                                      
REMARK 465     MET K   530                                                      
REMARK 465     VAL K   531                                                      
REMARK 465     PRO K   532                                                      
REMARK 465     LYS K   533                                                      
REMARK 465     LYS K   534                                                      
REMARK 465     ASP K   535                                                      
REMARK 465     SER K   536                                                      
REMARK 465     GLY K   537                                                      
REMARK 465     TYR K   538                                                      
REMARK 465     TYR K   539                                                      
REMARK 465     GLN K   540                                                      
REMARK 465     SER K   541                                                      
REMARK 465     GLY K   542                                                      
REMARK 465     PRO K   543                                                      
REMARK 465     GLY K   544                                                      
REMARK 465     SER K   545                                                      
REMARK 465     LYS K   546                                                      
REMARK 465     GLU K   547                                                      
REMARK 465     ASP K   548                                                      
REMARK 465     ARG K   549                                                      
REMARK 465     VAL K   550                                                      
REMARK 465     LYS K   551                                                      
REMARK 465     TYR K   552                                                      
REMARK 465     GLU K   553                                                      
REMARK 465     LYS K   554                                                      
REMARK 465     GLN K   555                                                      
REMARK 465     SER K   556                                                      
REMARK 465     LEU K   655                                                      
REMARK 465     ARG K   656                                                      
REMARK 465     ASN K   657                                                      
REMARK 465     VAL K   658                                                      
REMARK 465     MET L     1                                                      
REMARK 465     LEU L     2                                                      
REMARK 465     LYS L     3                                                      
REMARK 465     GLU L     4                                                      
REMARK 465     TRP L     5                                                      
REMARK 465     MET L     6                                                      
REMARK 465     ILE L     7                                                      
REMARK 465     PHE L     8                                                      
REMARK 465     THR L     9                                                      
REMARK 465     CYS L    10                                                      
REMARK 465     SER L    11                                                      
REMARK 465     LEU L    12                                                      
REMARK 465     LEU L    13                                                      
REMARK 465     THR L    14                                                      
REMARK 465     LEU L    15                                                      
REMARK 465     ALA L    16                                                      
REMARK 465     GLY L    17                                                      
REMARK 465     ALA L    18                                                      
REMARK 465     SER L    19                                                      
REMARK 465     LEU L    20                                                      
REMARK 465     PRO L    21                                                      
REMARK 465     LEU L    22                                                      
REMARK 465     SER L    23                                                      
REMARK 465     GLY L    24                                                      
REMARK 465     CYS L    25                                                      
REMARK 465     ILE L    26                                                      
REMARK 465     SER L    27                                                      
REMARK 465     ARG L    28                                                      
REMARK 465     GLY L    29                                                      
REMARK 465     GLN L    30                                                      
REMARK 465     GLU L    31                                                      
REMARK 465     SER L    32                                                      
REMARK 465     ILE L    33                                                      
REMARK 465     SER L    34                                                      
REMARK 465     GLU L    35                                                      
REMARK 465     GLY L    36                                                      
REMARK 465     ALA L    37                                                      
REMARK 465     ALA L    38                                                      
REMARK 465     PHE L    39                                                      
REMARK 465     GLY L    40                                                      
REMARK 465     ALA L    41                                                      
REMARK 465     GLY L    42                                                      
REMARK 465     ILE L    43                                                      
REMARK 465     LEU L    44                                                      
REMARK 465     ARG L    45                                                      
REMARK 465     GLU L    46                                                      
REMARK 465     PRO L    47                                                      
REMARK 465     GLY L    48                                                      
REMARK 465     ALA L    49                                                      
REMARK 465     THR L    50                                                      
REMARK 465     LYS L    51                                                      
REMARK 465     LYS L    52                                                      
REMARK 465     ALA L    53                                                      
REMARK 465     ASP L    54                                                      
REMARK 465     THR L    55                                                      
REMARK 465     LYS L    56                                                      
REMARK 465     ASP L    57                                                      
REMARK 465     LEU L    58                                                      
REMARK 465     ASN L    59                                                      
REMARK 465     VAL L    60                                                      
REMARK 465     PRO L    61                                                      
REMARK 465     PRO L   268                                                      
REMARK 465     SER L   269                                                      
REMARK 465     GLU L   270                                                      
REMARK 465     SER L   271                                                      
REMARK 465     LYS L   272                                                      
REMARK 465     ILE L   273                                                      
REMARK 465     GLN L   274                                                      
REMARK 465     MET M     1                                                      
REMARK 465     SER M     2                                                      
REMARK 465     THR M     3                                                      
REMARK 465     ASN M     4                                                      
REMARK 465     LYS M     5                                                      
REMARK 465     SER M     6                                                      
REMARK 465     GLU M     7                                                      
REMARK 465     PRO M     8                                                      
REMARK 465     THR M     9                                                      
REMARK 465     ARG M    10                                                      
REMARK 465     LYS M    11                                                      
REMARK 465     VAL M    12                                                      
REMARK 465     ASP M    13                                                      
REMARK 465     VAL M    14                                                      
REMARK 465     HIS M    15                                                      
REMARK 465     LEU M    16                                                      
REMARK 465     THR M    17                                                      
REMARK 465     ASP M    18                                                      
REMARK 465     ASN M    19                                                      
REMARK 465     GLY M    20                                                      
REMARK 465     THR M    21                                                      
REMARK 465     PRO M    22                                                      
REMARK 465     PHE M    23                                                      
REMARK 465     ALA M    24                                                      
REMARK 465     TYR M    25                                                      
REMARK 465     SER M    26                                                      
REMARK 465     MET M    27                                                      
REMARK 465     THR M    28                                                      
REMARK 465     SER M    29                                                      
REMARK 465     HIS M    30                                                      
REMARK 465     LYS M    31                                                      
REMARK 465     ASN M    32                                                      
REMARK 465     VAL M    33                                                      
REMARK 465     LYS M    34                                                      
REMARK 465     VAL M    35                                                      
REMARK 465     ARG M    36                                                      
REMARK 465     ALA M    37                                                      
REMARK 465     GLU M    38                                                      
REMARK 465     VAL M    39                                                      
REMARK 465     GLN M    40                                                      
REMARK 465     ASN M    97                                                      
REMARK 465     SER M    98                                                      
REMARK 465     ASP M    99                                                      
REMARK 465     LYS M   100                                                      
REMARK 465     SER M   101                                                      
REMARK 465     GLU M   102                                                      
REMARK 465     GLY M   103                                                      
REMARK 465     GLY M   104                                                      
REMARK 465     TRP M   105                                                      
REMARK 465     GLU M   106                                                      
REMARK 465     HIS M   107                                                      
REMARK 465     THR M   108                                                      
REMARK 465     TYR M   109                                                      
REMARK 465     GLU M   110                                                      
REMARK 465     ILE M   111                                                      
REMARK 465     GLU M   112                                                      
REMARK 465     GLY M   113                                                      
REMARK 465     SER M   114                                                      
REMARK 465     GLN M   115                                                      
REMARK 465     ASN M   204                                                      
REMARK 465     PRO M   205                                                      
REMARK 465     SER M   206                                                      
REMARK 465     LEU M   207                                                      
REMARK 465     LEU M   208                                                      
REMARK 465     GLY M   209                                                      
REMARK 465     GLY M   221                                                      
REMARK 465     GLU M   222                                                      
REMARK 465     ARG M   223                                                      
REMARK 465     ARG M   330                                                      
REMARK 465     LEU M   331                                                      
REMARK 465     LYS M   332                                                      
REMARK 465     GLN M   333                                                      
REMARK 465     GLN M   334                                                      
REMARK 465     GLY M   335                                                      
REMARK 465     CYS M   336                                                      
REMARK 465     ASP M   337                                                      
REMARK 465     ASN M   338                                                      
REMARK 465     LEU M   339                                                      
REMARK 465     LEU M   340                                                      
REMARK 465     ALA M   341                                                      
REMARK 465     GLY M   342                                                      
REMARK 465     MET M   343                                                      
REMARK 465     SER M   344                                                      
REMARK 465     SER M   345                                                      
REMARK 465     ASP M   346                                                      
REMARK 465     GLY M   347                                                      
REMARK 465     ASN M   348                                                      
REMARK 465     SER M   349                                                      
REMARK 465     LEU M   522                                                      
REMARK 465     TYR M   523                                                      
REMARK 465     GLY M   524                                                      
REMARK 465     TYR M   525                                                      
REMARK 465     PHE M   526                                                      
REMARK 465     ASP M   527                                                      
REMARK 465     ARG M   528                                                      
REMARK 465     LYS M   529                                                      
REMARK 465     MET M   530                                                      
REMARK 465     VAL M   531                                                      
REMARK 465     PRO M   532                                                      
REMARK 465     LYS M   533                                                      
REMARK 465     LYS M   534                                                      
REMARK 465     ASP M   535                                                      
REMARK 465     SER M   536                                                      
REMARK 465     GLY M   537                                                      
REMARK 465     TYR M   538                                                      
REMARK 465     TYR M   539                                                      
REMARK 465     GLN M   540                                                      
REMARK 465     SER M   541                                                      
REMARK 465     GLY M   542                                                      
REMARK 465     PRO M   543                                                      
REMARK 465     GLY M   544                                                      
REMARK 465     SER M   545                                                      
REMARK 465     LYS M   546                                                      
REMARK 465     GLU M   547                                                      
REMARK 465     ASP M   548                                                      
REMARK 465     ARG M   549                                                      
REMARK 465     VAL M   550                                                      
REMARK 465     LYS M   551                                                      
REMARK 465     TYR M   552                                                      
REMARK 465     GLU M   553                                                      
REMARK 465     LYS M   554                                                      
REMARK 465     GLN M   555                                                      
REMARK 465     SER M   556                                                      
REMARK 465     ARG M   654                                                      
REMARK 465     LEU M   655                                                      
REMARK 465     ARG M   656                                                      
REMARK 465     ASN M   657                                                      
REMARK 465     VAL M   658                                                      
REMARK 465     MET N     1                                                      
REMARK 465     LEU N     2                                                      
REMARK 465     LYS N     3                                                      
REMARK 465     GLU N     4                                                      
REMARK 465     TRP N     5                                                      
REMARK 465     MET N     6                                                      
REMARK 465     ILE N     7                                                      
REMARK 465     PHE N     8                                                      
REMARK 465     THR N     9                                                      
REMARK 465     CYS N    10                                                      
REMARK 465     SER N    11                                                      
REMARK 465     LEU N    12                                                      
REMARK 465     LEU N    13                                                      
REMARK 465     THR N    14                                                      
REMARK 465     LEU N    15                                                      
REMARK 465     ALA N    16                                                      
REMARK 465     GLY N    17                                                      
REMARK 465     ALA N    18                                                      
REMARK 465     SER N    19                                                      
REMARK 465     LEU N    20                                                      
REMARK 465     PRO N    21                                                      
REMARK 465     LEU N    22                                                      
REMARK 465     SER N    23                                                      
REMARK 465     GLY N    24                                                      
REMARK 465     CYS N    25                                                      
REMARK 465     ILE N    26                                                      
REMARK 465     SER N    27                                                      
REMARK 465     ARG N    28                                                      
REMARK 465     GLY N    29                                                      
REMARK 465     GLN N    30                                                      
REMARK 465     GLU N    31                                                      
REMARK 465     SER N    32                                                      
REMARK 465     ILE N    33                                                      
REMARK 465     SER N    34                                                      
REMARK 465     GLU N    35                                                      
REMARK 465     GLY N    36                                                      
REMARK 465     ALA N    37                                                      
REMARK 465     ALA N    38                                                      
REMARK 465     PHE N    39                                                      
REMARK 465     GLY N    40                                                      
REMARK 465     ALA N    41                                                      
REMARK 465     GLY N    42                                                      
REMARK 465     ILE N    43                                                      
REMARK 465     LEU N    44                                                      
REMARK 465     ARG N    45                                                      
REMARK 465     GLU N    46                                                      
REMARK 465     PRO N    47                                                      
REMARK 465     GLY N    48                                                      
REMARK 465     ALA N    49                                                      
REMARK 465     THR N    50                                                      
REMARK 465     LYS N    51                                                      
REMARK 465     LYS N    52                                                      
REMARK 465     ALA N    53                                                      
REMARK 465     ASP N    54                                                      
REMARK 465     THR N    55                                                      
REMARK 465     LYS N    56                                                      
REMARK 465     ASP N    57                                                      
REMARK 465     LEU N    58                                                      
REMARK 465     ASN N    59                                                      
REMARK 465     VAL N    60                                                      
REMARK 465     GLN N   267                                                      
REMARK 465     PRO N   268                                                      
REMARK 465     SER N   269                                                      
REMARK 465     GLU N   270                                                      
REMARK 465     SER N   271                                                      
REMARK 465     LYS N   272                                                      
REMARK 465     ILE N   273                                                      
REMARK 465     GLN N   274                                                      
REMARK 465     MET O     1                                                      
REMARK 465     SER O     2                                                      
REMARK 465     THR O     3                                                      
REMARK 465     ASN O     4                                                      
REMARK 465     LYS O     5                                                      
REMARK 465     SER O     6                                                      
REMARK 465     GLU O     7                                                      
REMARK 465     PRO O     8                                                      
REMARK 465     THR O     9                                                      
REMARK 465     ARG O    10                                                      
REMARK 465     LYS O    11                                                      
REMARK 465     VAL O    12                                                      
REMARK 465     ASP O    13                                                      
REMARK 465     VAL O    14                                                      
REMARK 465     HIS O    15                                                      
REMARK 465     LEU O    16                                                      
REMARK 465     THR O    17                                                      
REMARK 465     ASP O    18                                                      
REMARK 465     ASN O    19                                                      
REMARK 465     GLY O    20                                                      
REMARK 465     THR O    21                                                      
REMARK 465     PRO O    22                                                      
REMARK 465     PHE O    23                                                      
REMARK 465     ALA O    24                                                      
REMARK 465     TYR O    25                                                      
REMARK 465     SER O    26                                                      
REMARK 465     MET O    27                                                      
REMARK 465     THR O    28                                                      
REMARK 465     SER O    29                                                      
REMARK 465     HIS O    30                                                      
REMARK 465     LYS O    31                                                      
REMARK 465     ASN O    32                                                      
REMARK 465     VAL O    33                                                      
REMARK 465     LYS O    34                                                      
REMARK 465     VAL O    35                                                      
REMARK 465     ARG O    36                                                      
REMARK 465     ALA O    37                                                      
REMARK 465     GLU O    38                                                      
REMARK 465     VAL O    39                                                      
REMARK 465     GLN O    40                                                      
REMARK 465     PRO O    41                                                      
REMARK 465     PRO O    42                                                      
REMARK 465     LEU O    43                                                      
REMARK 465     GLN O    44                                                      
REMARK 465     LEU O    45                                                      
REMARK 465     ASN O    97                                                      
REMARK 465     SER O    98                                                      
REMARK 465     ASP O    99                                                      
REMARK 465     LYS O   100                                                      
REMARK 465     SER O   101                                                      
REMARK 465     GLU O   102                                                      
REMARK 465     GLY O   103                                                      
REMARK 465     GLY O   104                                                      
REMARK 465     TRP O   105                                                      
REMARK 465     GLU O   106                                                      
REMARK 465     HIS O   107                                                      
REMARK 465     THR O   108                                                      
REMARK 465     TYR O   109                                                      
REMARK 465     GLU O   110                                                      
REMARK 465     ILE O   111                                                      
REMARK 465     GLU O   112                                                      
REMARK 465     GLY O   113                                                      
REMARK 465     SER O   114                                                      
REMARK 465     GLN O   115                                                      
REMARK 465     ASN O   204                                                      
REMARK 465     PRO O   205                                                      
REMARK 465     SER O   206                                                      
REMARK 465     LEU O   207                                                      
REMARK 465     LEU O   208                                                      
REMARK 465     GLY O   209                                                      
REMARK 465     GLY O   221                                                      
REMARK 465     GLU O   222                                                      
REMARK 465     ARG O   223                                                      
REMARK 465     ARG O   330                                                      
REMARK 465     LEU O   331                                                      
REMARK 465     LYS O   332                                                      
REMARK 465     GLN O   333                                                      
REMARK 465     GLN O   334                                                      
REMARK 465     GLY O   335                                                      
REMARK 465     CYS O   336                                                      
REMARK 465     ASP O   337                                                      
REMARK 465     ASN O   338                                                      
REMARK 465     LEU O   339                                                      
REMARK 465     LEU O   340                                                      
REMARK 465     ALA O   341                                                      
REMARK 465     GLY O   342                                                      
REMARK 465     MET O   343                                                      
REMARK 465     SER O   344                                                      
REMARK 465     SER O   345                                                      
REMARK 465     ASP O   346                                                      
REMARK 465     GLY O   347                                                      
REMARK 465     ASN O   348                                                      
REMARK 465     SER O   349                                                      
REMARK 465     LEU O   522                                                      
REMARK 465     TYR O   523                                                      
REMARK 465     GLY O   524                                                      
REMARK 465     TYR O   525                                                      
REMARK 465     PHE O   526                                                      
REMARK 465     ASP O   527                                                      
REMARK 465     ARG O   528                                                      
REMARK 465     LYS O   529                                                      
REMARK 465     MET O   530                                                      
REMARK 465     VAL O   531                                                      
REMARK 465     PRO O   532                                                      
REMARK 465     LYS O   533                                                      
REMARK 465     LYS O   534                                                      
REMARK 465     ASP O   535                                                      
REMARK 465     SER O   536                                                      
REMARK 465     GLY O   537                                                      
REMARK 465     TYR O   538                                                      
REMARK 465     TYR O   539                                                      
REMARK 465     GLN O   540                                                      
REMARK 465     SER O   541                                                      
REMARK 465     GLY O   542                                                      
REMARK 465     PRO O   543                                                      
REMARK 465     GLY O   544                                                      
REMARK 465     SER O   545                                                      
REMARK 465     LYS O   546                                                      
REMARK 465     GLU O   547                                                      
REMARK 465     ASP O   548                                                      
REMARK 465     ARG O   549                                                      
REMARK 465     VAL O   550                                                      
REMARK 465     LYS O   551                                                      
REMARK 465     TYR O   552                                                      
REMARK 465     GLU O   553                                                      
REMARK 465     LYS O   554                                                      
REMARK 465     GLN O   555                                                      
REMARK 465     SER O   556                                                      
REMARK 465     GLN O   557                                                      
REMARK 465     TYR O   596                                                      
REMARK 465     CYS O   597                                                      
REMARK 465     TRP O   598                                                      
REMARK 465     HIS O   599                                                      
REMARK 465     LEU O   655                                                      
REMARK 465     ARG O   656                                                      
REMARK 465     ASN O   657                                                      
REMARK 465     VAL O   658                                                      
REMARK 465     MET P     1                                                      
REMARK 465     LEU P     2                                                      
REMARK 465     LYS P     3                                                      
REMARK 465     GLU P     4                                                      
REMARK 465     TRP P     5                                                      
REMARK 465     MET P     6                                                      
REMARK 465     ILE P     7                                                      
REMARK 465     PHE P     8                                                      
REMARK 465     THR P     9                                                      
REMARK 465     CYS P    10                                                      
REMARK 465     SER P    11                                                      
REMARK 465     LEU P    12                                                      
REMARK 465     LEU P    13                                                      
REMARK 465     THR P    14                                                      
REMARK 465     LEU P    15                                                      
REMARK 465     ALA P    16                                                      
REMARK 465     GLY P    17                                                      
REMARK 465     ALA P    18                                                      
REMARK 465     SER P    19                                                      
REMARK 465     LEU P    20                                                      
REMARK 465     PRO P    21                                                      
REMARK 465     LEU P    22                                                      
REMARK 465     SER P    23                                                      
REMARK 465     GLY P    24                                                      
REMARK 465     CYS P    25                                                      
REMARK 465     ILE P    26                                                      
REMARK 465     SER P    27                                                      
REMARK 465     ARG P    28                                                      
REMARK 465     GLY P    29                                                      
REMARK 465     GLN P    30                                                      
REMARK 465     GLU P    31                                                      
REMARK 465     SER P    32                                                      
REMARK 465     ILE P    33                                                      
REMARK 465     SER P    34                                                      
REMARK 465     GLU P    35                                                      
REMARK 465     GLY P    36                                                      
REMARK 465     ALA P    37                                                      
REMARK 465     ALA P    38                                                      
REMARK 465     PHE P    39                                                      
REMARK 465     GLY P    40                                                      
REMARK 465     ALA P    41                                                      
REMARK 465     GLY P    42                                                      
REMARK 465     ILE P    43                                                      
REMARK 465     LEU P    44                                                      
REMARK 465     ARG P    45                                                      
REMARK 465     GLU P    46                                                      
REMARK 465     PRO P    47                                                      
REMARK 465     GLY P    48                                                      
REMARK 465     ALA P    49                                                      
REMARK 465     THR P    50                                                      
REMARK 465     LYS P    51                                                      
REMARK 465     LYS P    52                                                      
REMARK 465     ALA P    53                                                      
REMARK 465     ASP P    54                                                      
REMARK 465     THR P    55                                                      
REMARK 465     LYS P    56                                                      
REMARK 465     ASP P    57                                                      
REMARK 465     LEU P    58                                                      
REMARK 465     ASN P    59                                                      
REMARK 465     VAL P    60                                                      
REMARK 465     PRO P    61                                                      
REMARK 465     PRO P    62                                                      
REMARK 465     PRO P    63                                                      
REMARK 465     VAL P    64                                                      
REMARK 465     SER P   269                                                      
REMARK 465     GLU P   270                                                      
REMARK 465     SER P   271                                                      
REMARK 465     LYS P   272                                                      
REMARK 465     ILE P   273                                                      
REMARK 465     GLN P   274                                                      
REMARK 470                                                                      
REMARK 470 MISSING ATOM                                                         
REMARK 470 THE FOLLOWING RESIDUES HAVE MISSING ATOMS (M=MODEL NUMBER;           
REMARK 470 RES=RESIDUE NAME; C=CHAIN IDENTIFIER; SSEQ=SEQUENCE NUMBER;          
REMARK 470 I=INSERTION CODE):                                                   
REMARK 470   M RES CSSEQI  ATOMS                                                
REMARK 470     GLU A  38    CG   CD   OE1  OE2                                  
REMARK 470     VAL A  39    CG1  CG2                                            
REMARK 470     LEU A  43    CG   CD1  CD2                                       
REMARK 470     GLU A  82    CG   CD   OE1  OE2                                  
REMARK 470     LYS A 116    CG   CD   CE   NZ                                   
REMARK 470     LYS A 117    CG   CD   CE   NZ                                   
REMARK 470     LYS A 124    CG   CD   CE   NZ                                   
REMARK 470     LYS A 127    CG   CD   CE   NZ                                   
REMARK 470     ARG A 132    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ARG A 172    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLN A 217    CG   CD   OE1  NE2                                  
REMARK 470     VAL A 218    CG1  CG2                                            
REMARK 470     LEU A 219    CG   CD1  CD2                                       
REMARK 470     ARG A 223    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ASP A 224    CG   OD1  OD2                                       
REMARK 470     LYS A 248    CG   CD   CE   NZ                                   
REMARK 470     ILE A 300    CG1  CG2  CD1                                       
REMARK 470     ARG A 310    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LYS A 311    CG   CD   CE   NZ                                   
REMARK 470     LYS A 332    CG   CD   CE   NZ                                   
REMARK 470     TRP A 350    CG   CD1  CD2  NE1  CE2  CE3  CZ2                   
REMARK 470     TRP A 350    CZ3  CH2                                            
REMARK 470     GLU A 353    CG   CD   OE1  OE2                                  
REMARK 470     LYS A 355    CG   CD   CE   NZ                                   
REMARK 470     HIS A 357    CG   ND1  CD2  CE1  NE2                             
REMARK 470     ASN A 358    CG   OD1  ND2                                       
REMARK 470     GLU A 362    CG   CD   OE1  OE2                                  
REMARK 470     LYS A 406    CG   CD   CE   NZ                                   
REMARK 470     GLU A 473    CG   CD   OE1  OE2                                  
REMARK 470     ARG A 489    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU A 491    CG   CD   OE1  OE2                                  
REMARK 470     LYS A 492    CG   CD   CE   NZ                                   
REMARK 470     TYR A 499    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     LYS A 509    CG   CD   CE   NZ                                   
REMARK 470     LYS A 510    CG   CD   CE   NZ                                   
REMARK 470     ASP A 513    CG   OD1  OD2                                       
REMARK 470     GLU A 558    CG   CD   OE1  OE2                                  
REMARK 470     GLU A 559    CG   CD   OE1  OE2                                  
REMARK 470     MET A 560    CG   SD   CE                                        
REMARK 470     LEU A 561    CG   CD1  CD2                                       
REMARK 470     GLU A 562    CG   CD   OE1  OE2                                  
REMARK 470     GLU A 563    CG   CD   OE1  OE2                                  
REMARK 470     ARG A 565    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LYS A 603    CG   CD   CE   NZ                                   
REMARK 470     LYS A 626    CG   CD   CE   NZ                                   
REMARK 470     LYS A 637    CG   CD   CE   NZ                                   
REMARK 470     ASP A 643    CG   OD1  OD2                                       
REMARK 470     GLU A 645    CG   CD   OE1  OE2                                  
REMARK 470     GLN A 646    CG   CD   OE1  NE2                                  
REMARK 470     ARG A 647    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LYS A 648    CG   CD   CE   NZ                                   
REMARK 470     GLU A 650    CG   CD   OE1  OE2                                  
REMARK 470     GLU A 651    CG   CD   OE1  OE2                                  
REMARK 470     LYS A 652    CG   CD   CE   NZ                                   
REMARK 470     ARG A 654    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LEU A 655    CG   CD1  CD2                                       
REMARK 470     ARG A 656    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LEU C  43    CG   CD1  CD2                                       
REMARK 470     GLN C  44    CG   CD   OE1  NE2                                  
REMARK 470     HIS C  53    CG   ND1  CD2  CE1  NE2                             
REMARK 470     ARG C  76    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU C  82    CG   CD   OE1  OE2                                  
REMARK 470     LYS C  86    CG   CD   CE   NZ                                   
REMARK 470     LYS C 116    CG   CD   CE   NZ                                   
REMARK 470     LYS C 124    CG   CD   CE   NZ                                   
REMARK 470     LYS C 127    CG   CD   CE   NZ                                   
REMARK 470     ARG C 132    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ARG C 172    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLN C 186    CG   CD   OE1  NE2                                  
REMARK 470     ASP C 224    CG   OD1  OD2                                       
REMARK 470     LEU C 226    CG   CD1  CD2                                       
REMARK 470     LYS C 248    CG   CD   CE   NZ                                   
REMARK 470     HIS C 254    CG   ND1  CD2  CE1  NE2                             
REMARK 470     ILE C 300    CG1  CG2  CD1                                       
REMARK 470     ARG C 310    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LYS C 311    CG   CD   CE   NZ                                   
REMARK 470     GLU C 353    CG   CD   OE1  OE2                                  
REMARK 470     LYS C 355    CG   CD   CE   NZ                                   
REMARK 470     HIS C 357    CG   ND1  CD2  CE1  NE2                             
REMARK 470     ASN C 358    CG   OD1  ND2                                       
REMARK 470     LYS C 406    CG   CD   CE   NZ                                   
REMARK 470     GLU C 473    CG   CD   OE1  OE2                                  
REMARK 470     ARG C 489    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU C 491    CG   CD   OE1  OE2                                  
REMARK 470     LYS C 492    CG   CD   CE   NZ                                   
REMARK 470     TYR C 499    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     LYS C 509    CG   CD   CE   NZ                                   
REMARK 470     LYS C 510    CG   CD   CE   NZ                                   
REMARK 470     ASP C 513    CG   OD1  OD2                                       
REMARK 470     LEU C 522    CG   CD1  CD2                                       
REMARK 470     GLU C 559    CG   CD   OE1  OE2                                  
REMARK 470     MET C 560    CG   SD   CE                                        
REMARK 470     LEU C 561    CG   CD1  CD2                                       
REMARK 470     GLU C 562    CG   CD   OE1  OE2                                  
REMARK 470     GLU C 563    CG   CD   OE1  OE2                                  
REMARK 470     ARG C 565    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     TYR C 596    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     HIS C 599    CG   ND1  CD2  CE1  NE2                             
REMARK 470     LYS C 626    CG   CD   CE   NZ                                   
REMARK 470     LYS C 637    CG   CD   CE   NZ                                   
REMARK 470     GLU C 645    CG   CD   OE1  OE2                                  
REMARK 470     GLN C 646    CG   CD   OE1  NE2                                  
REMARK 470     ARG C 647    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LYS C 648    CG   CD   CE   NZ                                   
REMARK 470     GLU C 650    CG   CD   OE1  OE2                                  
REMARK 470     GLU C 651    CG   CD   OE1  OE2                                  
REMARK 470     LYS C 652    CG   CD   CE   NZ                                   
REMARK 470     ARG C 654    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LYS B  98    CG   CD   CE   NZ                                   
REMARK 470     HIS B 138    CG   ND1  CD2  CE1  NE2                             
REMARK 470     LYS B 160    CG   CD   CE   NZ                                   
REMARK 470     ARG B 161    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ARG B 208    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ASP B 224    CG   OD1  OD2                                       
REMARK 470     GLU B 227    CG   CD   OE1  OE2                                  
REMARK 470     ARG B 230    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU B 233    CG   CD   OE1  OE2                                  
REMARK 470     GLU B 234    CG   CD   OE1  OE2                                  
REMARK 470     LYS B 242    CG   CD   CE   NZ                                   
REMARK 470     ARG B 247    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LYS B 251    CG   CD   CE   NZ                                   
REMARK 470     GLU B 270    CG   CD   OE1  OE2                                  
REMARK 470     LYS B 272    CG   CD   CE   NZ                                   
REMARK 470     GLN E  40    CG   CD   OE1  NE2                                  
REMARK 470     LEU E  43    CG   CD1  CD2                                       
REMARK 470     GLN E  44    CG   CD   OE1  NE2                                  
REMARK 470     GLU E  60    OE1  OE2                                            
REMARK 470     GLU E  82    CG   CD   OE1  OE2                                  
REMARK 470     LYS E  86    CG   CD   CE   NZ                                   
REMARK 470     LYS E 116    CG   CD   CE   NZ                                   
REMARK 470     LYS E 117    CG   CD   CE   NZ                                   
REMARK 470     LYS E 124    CG   CD   CE   NZ                                   
REMARK 470     LYS E 127    CG   CD   CE   NZ                                   
REMARK 470     ARG E 132    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ARG E 172    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLN E 186    CG   CD   OE1  NE2                                  
REMARK 470     ASN E 204    CG   OD1  ND2                                       
REMARK 470     LEU E 208    CG   CD1  CD2                                       
REMARK 470     GLN E 217    CG   CD   OE1  NE2                                  
REMARK 470     VAL E 218    CG1  CG2                                            
REMARK 470     LEU E 219    CG   CD1  CD2                                       
REMARK 470     GLU E 222    CG   CD   OE1  OE2                                  
REMARK 470     ARG E 223    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ASP E 224    CG   OD1  OD2                                       
REMARK 470     ARG E 225    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LEU E 226    CG   CD1  CD2                                       
REMARK 470     LYS E 248    CG   CD   CE   NZ                                   
REMARK 470     GLU E 256    CG   CD   OE1  OE2                                  
REMARK 470     ILE E 300    CG1  CG2  CD1                                       
REMARK 470     ARG E 310    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LYS E 311    CG   CD   CE   NZ                                   
REMARK 470     LYS E 328    CG   CD   CE   NZ                                   
REMARK 470     ARG E 330    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LEU E 331    CG   CD1  CD2                                       
REMARK 470     ASN E 348    CG   OD1  ND2                                       
REMARK 470     SER E 349    OG                                                  
REMARK 470     GLU E 353    CG   CD   OE1  OE2                                  
REMARK 470     LYS E 355    CG   CD   CE   NZ                                   
REMARK 470     HIS E 357    CG   ND1  CD2  CE1  NE2                             
REMARK 470     ASN E 358    CG   OD1  ND2                                       
REMARK 470     GLU E 362    CG   CD   OE1  OE2                                  
REMARK 470     LYS E 406    CG   CD   CE   NZ                                   
REMARK 470     GLU E 473    CG   CD   OE1  OE2                                  
REMARK 470     ARG E 489    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU E 491    CG   CD   OE1  OE2                                  
REMARK 470     LYS E 492    CG   CD   CE   NZ                                   
REMARK 470     TYR E 499    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     LYS E 509    CG   CD   CE   NZ                                   
REMARK 470     LYS E 510    CG   CD   CE   NZ                                   
REMARK 470     ASP E 513    CG   OD1  OD2                                       
REMARK 470     LEU E 522    CG   CD1  CD2                                       
REMARK 470     PHE E 526    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     ASP E 527    CG   OD1  OD2                                       
REMARK 470     ARG E 528    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     MET E 530    CG   SD   CE                                        
REMARK 470     VAL E 531    CG1  CG2                                            
REMARK 470     SER E 556    OG                                                  
REMARK 470     GLN E 557    CG   CD   OE1  NE2                                  
REMARK 470     MET E 560    CG   SD   CE                                        
REMARK 470     LEU E 561    CG   CD1  CD2                                       
REMARK 470     GLU E 562    CG   CD   OE1  OE2                                  
REMARK 470     GLU E 563    CG   CD   OE1  OE2                                  
REMARK 470     ARG E 565    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     HIS E 599    CG   ND1  CD2  CE1  NE2                             
REMARK 470     LYS E 626    CG   CD   CE   NZ                                   
REMARK 470     LYS E 637    CG   CD   CE   NZ                                   
REMARK 470     GLU E 645    CG   CD   OE1  OE2                                  
REMARK 470     LYS E 648    CG   CD   CE   NZ                                   
REMARK 470     GLU E 650    CG   CD   OE1  OE2                                  
REMARK 470     GLU E 651    CG   CD   OE1  OE2                                  
REMARK 470     LYS E 652    CG   CD   CE   NZ                                   
REMARK 470     ARG E 654    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LYS D  98    CG   CD   CE   NZ                                   
REMARK 470     HIS D 138    CG   ND1  CD2  CE1  NE2                             
REMARK 470     LYS D 160    CG   CD   CE   NZ                                   
REMARK 470     ASN D 187    CG   OD1  ND2                                       
REMARK 470     ARG D 208    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ASP D 224    CG   OD1  OD2                                       
REMARK 470     TYR D 226    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     GLU D 227    CG   CD   OE1  OE2                                  
REMARK 470     PHE D 229    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     ARG D 230    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU D 233    CG   CD   OE1  OE2                                  
REMARK 470     GLU D 234    CG   CD   OE1  OE2                                  
REMARK 470     LYS D 242    CG   CD   CE   NZ                                   
REMARK 470     ARG D 247    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LYS D 251    CG   CD   CE   NZ                                   
REMARK 470     LYS F  98    CG   CD   CE   NZ                                   
REMARK 470     HIS F 138    CG   ND1  CD2  CE1  NE2                             
REMARK 470     LYS F 160    CG   CD   CE   NZ                                   
REMARK 470     ASN F 187    CG   OD1  ND2                                       
REMARK 470     GLN F 199    CG   CD   OE1  NE2                                  
REMARK 470     ARG F 201    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ARG F 208    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ASP F 224    CG   OD1  OD2                                       
REMARK 470     TYR F 226    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     GLU F 227    CG   CD   OE1  OE2                                  
REMARK 470     PHE F 229    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     ARG F 230    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU F 233    CG   CD   OE1  OE2                                  
REMARK 470     LYS F 242    CG   CD   CE   NZ                                   
REMARK 470     ARG F 247    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LYS F 251    CG   CD   CE   NZ                                   
REMARK 470     GLU F 270    CG   CD   OE1  OE2                                  
REMARK 470     VAL G  39    CG1  CG2                                            
REMARK 470     GLN G  44    CG   CD   OE1  NE2                                  
REMARK 470     GLU G  82    CG   CD   OE1  OE2                                  
REMARK 470     LYS G  86    CG   CD   CE   NZ                                   
REMARK 470     LYS G 116    CG   CD   CE   NZ                                   
REMARK 470     LYS G 117    CG   CD   CE   NZ                                   
REMARK 470     LYS G 124    CG   CD   CE   NZ                                   
REMARK 470     LYS G 127    CG   CD   CE   NZ                                   
REMARK 470     ARG G 132    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ARG G 172    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLN G 186    CG   CD   OE1  NE2                                  
REMARK 470     ARG G 223    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ASP G 224    CG   OD1  OD2                                       
REMARK 470     ARG G 225    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LEU G 226    CG   CD1  CD2                                       
REMARK 470     LYS G 248    CG   CD   CE   NZ                                   
REMARK 470     ILE G 300    CG1  CG2  CD1                                       
REMARK 470     ARG G 310    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LYS G 311    CG   CD   CE   NZ                                   
REMARK 470     GLU G 326    CG   CD   OE1  OE2                                  
REMARK 470     ASN G 327    CG   OD1  ND2                                       
REMARK 470     LYS G 328    CG   CD   CE   NZ                                   
REMARK 470     THR G 329    OG1  CG2                                            
REMARK 470     ARG G 330    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LEU G 331    CG   CD1  CD2                                       
REMARK 470     LYS G 332    CG   CD   CE   NZ                                   
REMARK 470     GLN G 333    CG   CD   OE1  NE2                                  
REMARK 470     GLN G 334    CG   CD   OE1  NE2                                  
REMARK 470     ASN G 348    CG   OD1  ND2                                       
REMARK 470     GLU G 353    CG   CD   OE1  OE2                                  
REMARK 470     LYS G 355    CG   CD   CE   NZ                                   
REMARK 470     HIS G 357    CG   ND1  CD2  CE1  NE2                             
REMARK 470     ASN G 358    CG   OD1  ND2                                       
REMARK 470     LYS G 406    CG   CD   CE   NZ                                   
REMARK 470     GLU G 473    CG   CD   OE1  OE2                                  
REMARK 470     ARG G 489    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU G 491    CG   CD   OE1  OE2                                  
REMARK 470     LYS G 492    CG   CD   CE   NZ                                   
REMARK 470     TYR G 499    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     LYS G 509    CG   CD   CE   NZ                                   
REMARK 470     LYS G 510    CG   CD   CE   NZ                                   
REMARK 470     ASP G 513    CG   OD1  OD2                                       
REMARK 470     TYR G 525    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     PHE G 526    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     ASP G 527    CG   OD1  OD2                                       
REMARK 470     ARG G 528    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LYS G 529    CG   CD   CE   NZ                                   
REMARK 470     MET G 530    CG   SD   CE                                        
REMARK 470     VAL G 531    CG1  CG2                                            
REMARK 470     PRO G 532    CG   CD                                             
REMARK 470     LYS G 533    CG   CD   CE   NZ                                   
REMARK 470     GLU G 553    CG   CD   OE1  OE2                                  
REMARK 470     LYS G 554    CG   CD   CE   NZ                                   
REMARK 470     GLN G 555    CG   CD   OE1  NE2                                  
REMARK 470     SER G 556    OG                                                  
REMARK 470     GLU G 559    CG   CD   OE1  OE2                                  
REMARK 470     MET G 560    CG   SD   CE                                        
REMARK 470     LEU G 561    CG   CD1  CD2                                       
REMARK 470     GLU G 562    CG   CD   OE1  OE2                                  
REMARK 470     GLU G 563    CG   CD   OE1  OE2                                  
REMARK 470     ARG G 565    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     TYR G 596    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     TRP G 601    CG   CD1  CD2  NE1  CE2  CE3  CZ2                   
REMARK 470     TRP G 601    CZ3  CH2                                            
REMARK 470     LEU G 606    CG   CD1  CD2                                       
REMARK 470     LYS G 626    CG   CD   CE   NZ                                   
REMARK 470     LYS G 637    CG   CD   CE   NZ                                   
REMARK 470     GLU G 645    CG   CD   OE1  OE2                                  
REMARK 470     GLN G 646    CG   CD   OE1  NE2                                  
REMARK 470     ARG G 647    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LYS G 648    CG   CD   CE   NZ                                   
REMARK 470     GLU G 650    CG   CD   OE1  OE2                                  
REMARK 470     GLU G 651    CG   CD   OE1  OE2                                  
REMARK 470     LYS G 652    CG   CD   CE   NZ                                   
REMARK 470     LYS H  98    CG   CD   CE   NZ                                   
REMARK 470     HIS H 138    CG   ND1  CD2  CE1  NE2                             
REMARK 470     LYS H 160    CG   CD   CE   NZ                                   
REMARK 470     ARG H 161    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ARG H 162    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ASN H 187    CG   OD1  ND2                                       
REMARK 470     ARG H 208    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ASP H 224    CG   OD1  OD2                                       
REMARK 470     TYR H 226    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     GLU H 227    CG   CD   OE1  OE2                                  
REMARK 470     PHE H 229    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     ARG H 230    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU H 233    CG   CD   OE1  OE2                                  
REMARK 470     GLU H 234    CG   CD   OE1  OE2                                  
REMARK 470     LYS H 242    CG   CD   CE   NZ                                   
REMARK 470     ARG H 247    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LYS H 251    CG   CD   CE   NZ                                   
REMARK 470     GLN I  40    CG   CD   OE1  NE2                                  
REMARK 470     LEU I  43    CG   CD1  CD2                                       
REMARK 470     GLN I  44    CG   CD   OE1  NE2                                  
REMARK 470     GLU I  80    CG   CD   OE1  OE2                                  
REMARK 470     GLU I  82    CG   CD   OE1  OE2                                  
REMARK 470     LYS I  86    CG   CD   CE   NZ                                   
REMARK 470     LYS I 116    CG   CD   CE   NZ                                   
REMARK 470     LYS I 117    CG   CD   CE   NZ                                   
REMARK 470     LYS I 124    CG   CD   CE   NZ                                   
REMARK 470     LYS I 127    CG   CD   CE   NZ                                   
REMARK 470     ARG I 132    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ARG I 172    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLN I 186    CG   CD   OE1  NE2                                  
REMARK 470     LEU I 208    CG   CD1  CD2                                       
REMARK 470     GLN I 217    CG   CD   OE1  NE2                                  
REMARK 470     LEU I 219    CG   CD1  CD2                                       
REMARK 470     ASP I 224    CG   OD1  OD2                                       
REMARK 470     LEU I 226    CG   CD1  CD2                                       
REMARK 470     LYS I 248    CG   CD   CE   NZ                                   
REMARK 470     ILE I 300    CG1  CG2  CD1                                       
REMARK 470     ARG I 310    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LYS I 311    CG   CD   CE   NZ                                   
REMARK 470     LYS I 323    CG   CD   CE   NZ                                   
REMARK 470     GLU I 326    CG   CD   OE1  OE2                                  
REMARK 470     LYS I 328    CG   CD   CE   NZ                                   
REMARK 470     GLU I 353    CG   CD   OE1  OE2                                  
REMARK 470     LYS I 355    CG   CD   CE   NZ                                   
REMARK 470     HIS I 357    CG   ND1  CD2  CE1  NE2                             
REMARK 470     ASN I 358    CG   OD1  ND2                                       
REMARK 470     GLU I 362    CG   CD   OE1  OE2                                  
REMARK 470     LYS I 406    CG   CD   CE   NZ                                   
REMARK 470     GLU I 473    CG   CD   OE1  OE2                                  
REMARK 470     ARG I 489    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU I 491    CG   CD   OE1  OE2                                  
REMARK 470     LYS I 492    CG   CD   CE   NZ                                   
REMARK 470     TYR I 499    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     LYS I 509    CG   CD   CE   NZ                                   
REMARK 470     LYS I 510    CG   CD   CE   NZ                                   
REMARK 470     ASP I 513    CG   OD1  OD2                                       
REMARK 470     TYR I 552    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     GLU I 553    CG   CD   OE1  OE2                                  
REMARK 470     LYS I 554    CG   CD   CE   NZ                                   
REMARK 470     GLN I 555    CG   CD   OE1  NE2                                  
REMARK 470     SER I 556    OG                                                  
REMARK 470     GLU I 559    CG   CD   OE1  OE2                                  
REMARK 470     MET I 560    CG   SD   CE                                        
REMARK 470     LEU I 561    CG   CD1  CD2                                       
REMARK 470     GLU I 562    CG   CD   OE1  OE2                                  
REMARK 470     GLU I 563    CG   CD   OE1  OE2                                  
REMARK 470     ARG I 565    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     TYR I 596    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     HIS I 599    CG   ND1  CD2  CE1  NE2                             
REMARK 470     LYS I 626    CG   CD   CE   NZ                                   
REMARK 470     LYS I 637    CG   CD   CE   NZ                                   
REMARK 470     GLU I 642    CG   CD   OE1  OE2                                  
REMARK 470     ASP I 643    CG   OD1  OD2                                       
REMARK 470     GLU I 645    CG   CD   OE1  OE2                                  
REMARK 470     GLN I 646    CG   CD   OE1  NE2                                  
REMARK 470     ARG I 647    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LYS I 648    CG   CD   CE   NZ                                   
REMARK 470     GLU I 650    CG   CD   OE1  OE2                                  
REMARK 470     GLU I 651    CG   CD   OE1  OE2                                  
REMARK 470     LYS I 652    CG   CD   CE   NZ                                   
REMARK 470     ARG I 654    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LEU I 655    CG   CD1  CD2                                       
REMARK 470     ARG I 656    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LYS J  98    CG   CD   CE   NZ                                   
REMARK 470     HIS J 138    CG   ND1  CD2  CE1  NE2                             
REMARK 470     LYS J 160    CG   CD   CE   NZ                                   
REMARK 470     ASN J 187    CG   OD1  ND2                                       
REMARK 470     GLN J 199    CG   CD   OE1  NE2                                  
REMARK 470     ARG J 208    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ASP J 224    CG   OD1  OD2                                       
REMARK 470     TYR J 226    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     GLU J 227    CG   CD   OE1  OE2                                  
REMARK 470     PHE J 229    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     ARG J 230    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU J 233    CG   CD   OE1  OE2                                  
REMARK 470     LYS J 242    CG   CD   CE   NZ                                   
REMARK 470     ARG J 247    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LYS J 251    CG   CD   CE   NZ                                   
REMARK 470     LYS J 272    CG   CD   CE   NZ                                   
REMARK 470     ILE J 273    CG1  CG2  CD1                                       
REMARK 470     GLN J 274    CG   CD   OE1  NE2                                  
REMARK 470     GLU K  38    CG   CD   OE1  OE2                                  
REMARK 470     GLN K  40    CG   CD   OE1  NE2                                  
REMARK 470     GLN K  44    CG   CD   OE1  NE2                                  
REMARK 470     GLU K  82    CG   CD   OE1  OE2                                  
REMARK 470     LYS K  86    CG   CD   CE   NZ                                   
REMARK 470     LYS K 116    CG   CD   CE   NZ                                   
REMARK 470     LYS K 117    CG   CD   CE   NZ                                   
REMARK 470     LYS K 124    CG   CD   CE   NZ                                   
REMARK 470     LYS K 127    CG   CD   CE   NZ                                   
REMARK 470     ARG K 132    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ARG K 172    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLN K 186    CG   CD   OE1  NE2                                  
REMARK 470     GLN K 217    CG   CD   OE1  NE2                                  
REMARK 470     VAL K 218    CG1  CG2                                            
REMARK 470     LEU K 219    CG   CD1  CD2                                       
REMARK 470     ASN K 220    CG   OD1  ND2                                       
REMARK 470     ASP K 224    CG   OD1  OD2                                       
REMARK 470     LEU K 226    CG   CD1  CD2                                       
REMARK 470     LYS K 248    CG   CD   CE   NZ                                   
REMARK 470     HIS K 254    CG   ND1  CD2  CE1  NE2                             
REMARK 470     ILE K 300    CG1  CG2  CD1                                       
REMARK 470     ARG K 310    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LYS K 311    CG   CD   CE   NZ                                   
REMARK 470     ARG K 330    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LYS K 332    CG   CD   CE   NZ                                   
REMARK 470     GLN K 333    CG   CD   OE1  NE2                                  
REMARK 470     GLN K 334    CG   CD   OE1  NE2                                  
REMARK 470     CYS K 336    SG                                                  
REMARK 470     ASP K 346    CG   OD1  OD2                                       
REMARK 470     SER K 349    OG                                                  
REMARK 470     GLU K 353    CG   CD   OE1  OE2                                  
REMARK 470     LYS K 355    CG   CD   CE   NZ                                   
REMARK 470     HIS K 357    CG   ND1  CD2  CE1  NE2                             
REMARK 470     ASN K 358    CG   OD1  ND2                                       
REMARK 470     GLU K 362    CG   CD   OE1  OE2                                  
REMARK 470     LYS K 406    CG   CD   CE   NZ                                   
REMARK 470     GLU K 473    CG   CD   OE1  OE2                                  
REMARK 470     ARG K 489    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU K 491    CG   CD   OE1  OE2                                  
REMARK 470     LYS K 492    CG   CD   CE   NZ                                   
REMARK 470     TYR K 499    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     LYS K 509    CG   CD   CE   NZ                                   
REMARK 470     LYS K 510    CG   CD   CE   NZ                                   
REMARK 470     GLN K 557    CG   CD   OE1  NE2                                  
REMARK 470     GLU K 558    CG   CD   OE1  OE2                                  
REMARK 470     GLU K 559    CG   CD   OE1  OE2                                  
REMARK 470     MET K 560    CG   SD   CE                                        
REMARK 470     LEU K 561    CG   CD1  CD2                                       
REMARK 470     GLU K 562    CG   CD   OE1  OE2                                  
REMARK 470     GLU K 563    CG   CD   OE1  OE2                                  
REMARK 470     ARG K 565    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     TYR K 596    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     HIS K 599    CG   ND1  CD2  CE1  NE2                             
REMARK 470     LYS K 603    CG   CD   CE   NZ                                   
REMARK 470     LYS K 626    CG   CD   CE   NZ                                   
REMARK 470     LYS K 637    CG   CD   CE   NZ                                   
REMARK 470     GLU K 645    CG   CD   OE1  OE2                                  
REMARK 470     LYS K 648    CG   CD   CE   NZ                                   
REMARK 470     GLU K 650    CG   CD   OE1  OE2                                  
REMARK 470     GLU K 651    CG   CD   OE1  OE2                                  
REMARK 470     LYS K 652    CG   CD   CE   NZ                                   
REMARK 470     ARG K 654    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LYS L  98    CG   CD   CE   NZ                                   
REMARK 470     HIS L 138    CG   ND1  CD2  CE1  NE2                             
REMARK 470     LYS L 160    CG   CD   CE   NZ                                   
REMARK 470     ASN L 187    CG   OD1  ND2                                       
REMARK 470     ARG L 208    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ASP L 224    CG   OD1  OD2                                       
REMARK 470     TYR L 226    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     GLU L 227    CG   CD   OE1  OE2                                  
REMARK 470     PHE L 229    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     ARG L 230    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU L 233    CG   CD   OE1  OE2                                  
REMARK 470     GLU L 234    CG   CD   OE1  OE2                                  
REMARK 470     LYS L 242    CG   CD   CE   NZ                                   
REMARK 470     ARG L 247    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LYS L 251    CG   CD   CE   NZ                                   
REMARK 470     LEU M  43    CG   CD1  CD2                                       
REMARK 470     GLN M  44    CG   CD   OE1  NE2                                  
REMARK 470     GLU M  82    CG   CD   OE1  OE2                                  
REMARK 470     LYS M  86    CG   CD   CE   NZ                                   
REMARK 470     LYS M 116    CG   CD   CE   NZ                                   
REMARK 470     LYS M 117    CG   CD   CE   NZ                                   
REMARK 470     LYS M 124    CG   CD   CE   NZ                                   
REMARK 470     LYS M 127    CG   CD   CE   NZ                                   
REMARK 470     ARG M 132    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ARG M 172    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     PHE M 185    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     GLN M 186    CG   CD   OE1  NE2                                  
REMARK 470     GLN M 217    CG   CD   OE1  NE2                                  
REMARK 470     LEU M 219    CG   CD1  CD2                                       
REMARK 470     ASP M 224    CG   OD1  OD2                                       
REMARK 470     LEU M 226    CG   CD1  CD2                                       
REMARK 470     LYS M 248    CG   CD   CE   NZ                                   
REMARK 470     HIS M 254    CG   ND1  CD2  CE1  NE2                             
REMARK 470     ILE M 300    CG1  CG2  CD1                                       
REMARK 470     ARG M 310    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LYS M 311    CG   CD   CE   NZ                                   
REMARK 470     GLU M 353    CG   CD   OE1  OE2                                  
REMARK 470     LYS M 355    CG   CD   CE   NZ                                   
REMARK 470     HIS M 357    CG   ND1  CD2  CE1  NE2                             
REMARK 470     ASN M 358    CG   OD1  ND2                                       
REMARK 470     GLU M 362    CG   CD   OE1  OE2                                  
REMARK 470     LYS M 406    CG   CD   CE   NZ                                   
REMARK 470     GLU M 473    CG   CD   OE1  OE2                                  
REMARK 470     GLU M 491    CG   CD   OE1  OE2                                  
REMARK 470     LYS M 492    CG   CD   CE   NZ                                   
REMARK 470     GLN M 493    CG   CD   OE1  NE2                                  
REMARK 470     TYR M 499    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     LYS M 509    CG   CD   CE   NZ                                   
REMARK 470     LYS M 510    CG   CD   CE   NZ                                   
REMARK 470     ASP M 513    CG   OD1  OD2                                       
REMARK 470     GLN M 557    CG   CD   OE1  NE2                                  
REMARK 470     GLU M 558    CG   CD   OE1  OE2                                  
REMARK 470     GLU M 559    CG   CD   OE1  OE2                                  
REMARK 470     MET M 560    CG   SD   CE                                        
REMARK 470     LEU M 561    CG   CD1  CD2                                       
REMARK 470     GLU M 562    CG   CD   OE1  OE2                                  
REMARK 470     GLU M 563    CG   CD   OE1  OE2                                  
REMARK 470     ARG M 565    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     TYR M 596    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     HIS M 599    CG   ND1  CD2  CE1  NE2                             
REMARK 470     LYS M 626    CG   CD   CE   NZ                                   
REMARK 470     LYS M 637    CG   CD   CE   NZ                                   
REMARK 470     ASP M 643    CG   OD1  OD2                                       
REMARK 470     GLU M 645    CG   CD   OE1  OE2                                  
REMARK 470     GLN M 646    CG   CD   OE1  NE2                                  
REMARK 470     ARG M 647    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LYS M 648    CG   CD   CE   NZ                                   
REMARK 470     GLU M 650    CG   CD   OE1  OE2                                  
REMARK 470     GLU M 651    CG   CD   OE1  OE2                                  
REMARK 470     LYS M 652    CG   CD   CE   NZ                                   
REMARK 470     LYS N  98    CG   CD   CE   NZ                                   
REMARK 470     HIS N 138    CG   ND1  CD2  CE1  NE2                             
REMARK 470     LYS N 146    CG   CD   CE   NZ                                   
REMARK 470     LYS N 160    CG   CD   CE   NZ                                   
REMARK 470     ASN N 187    CG   OD1  ND2                                       
REMARK 470     ARG N 208    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ASP N 224    CG   OD1  OD2                                       
REMARK 470     TYR N 226    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     GLU N 227    CG   CD   OE1  OE2                                  
REMARK 470     PHE N 229    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     ARG N 230    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU N 233    CG   CD   OE1  OE2                                  
REMARK 470     GLU N 234    CG   CD   OE1  OE2                                  
REMARK 470     LYS N 242    CG   CD   CE   NZ                                   
REMARK 470     ARG N 247    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LYS N 251    CG   CD   CE   NZ                                   
REMARK 470     GLU O  82    CG   CD   OE1  OE2                                  
REMARK 470     LYS O  86    CG   CD   CE   NZ                                   
REMARK 470     LYS O 116    CG   CD   CE   NZ                                   
REMARK 470     LYS O 117    CG   CD   CE   NZ                                   
REMARK 470     LYS O 124    CG   CD   CE   NZ                                   
REMARK 470     LYS O 127    CG   CD   CE   NZ                                   
REMARK 470     ARG O 132    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ARG O 172    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     PHE O 185    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     GLN O 186    CG   CD   OE1  NE2                                  
REMARK 470     GLN O 217    CG   CD   OE1  NE2                                  
REMARK 470     VAL O 218    CG1  CG2                                            
REMARK 470     LEU O 219    CG   CD1  CD2                                       
REMARK 470     ASN O 220    CG   OD1  ND2                                       
REMARK 470     ASP O 224    CG   OD1  OD2                                       
REMARK 470     LEU O 226    CG   CD1  CD2                                       
REMARK 470     LYS O 248    CG   CD   CE   NZ                                   
REMARK 470     HIS O 254    CG   ND1  CD2  CE1  NE2                             
REMARK 470     ILE O 300    CG1  CG2  CD1                                       
REMARK 470     ARG O 310    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LYS O 311    CG   CD   CE   NZ                                   
REMARK 470     GLU O 353    CG   CD   OE1  OE2                                  
REMARK 470     LYS O 355    CG   CD   CE   NZ                                   
REMARK 470     HIS O 357    CG   ND1  CD2  CE1  NE2                             
REMARK 470     ASN O 358    CG   OD1  ND2                                       
REMARK 470     GLU O 362    CG   CD   OE1  OE2                                  
REMARK 470     LYS O 406    CG   CD   CE   NZ                                   
REMARK 470     GLU O 473    CG   CD   OE1  OE2                                  
REMARK 470     ARG O 489    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU O 491    CG   CD   OE1  OE2                                  
REMARK 470     LYS O 492    CG   CD   CE   NZ                                   
REMARK 470     TYR O 499    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     LYS O 509    CG   CD   CE   NZ                                   
REMARK 470     LYS O 510    CG   CD   CE   NZ                                   
REMARK 470     ASP O 513    CG   OD1  OD2                                       
REMARK 470     ILE O 520    CG1  CG2  CD1                                       
REMARK 470     GLU O 558    CG   CD   OE1  OE2                                  
REMARK 470     GLU O 559    CG   CD   OE1  OE2                                  
REMARK 470     MET O 560    CG   SD   CE                                        
REMARK 470     LEU O 561    CG   CD1  CD2                                       
REMARK 470     GLU O 562    CG   CD   OE1  OE2                                  
REMARK 470     GLU O 563    CG   CD   OE1  OE2                                  
REMARK 470     VAL O 564    CG1  CG2                                            
REMARK 470     ARG O 565    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLN O 569    CG   CD   OE1  NE2                                  
REMARK 470     LYS O 626    CG   CD   CE   NZ                                   
REMARK 470     LYS O 637    CG   CD   CE   NZ                                   
REMARK 470     ASP O 643    CG   OD1  OD2                                       
REMARK 470     GLU O 645    CG   CD   OE1  OE2                                  
REMARK 470     GLN O 646    CG   CD   OE1  NE2                                  
REMARK 470     ARG O 647    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LYS O 648    CG   CD   CE   NZ                                   
REMARK 470     GLU O 650    CG   CD   OE1  OE2                                  
REMARK 470     GLU O 651    CG   CD   OE1  OE2                                  
REMARK 470     LYS O 652    CG   CD   CE   NZ                                   
REMARK 470     ARG O 654    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LYS P  98    CG   CD   CE   NZ                                   
REMARK 470     HIS P 138    CG   ND1  CD2  CE1  NE2                             
REMARK 470     LYS P 160    CG   CD   CE   NZ                                   
REMARK 470     ASN P 187    CG   OD1  ND2                                       
REMARK 470     ARG P 208    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     ASP P 224    CG   OD1  OD2                                       
REMARK 470     TYR P 226    CG   CD1  CD2  CE1  CE2  CZ   OH                    
REMARK 470     GLU P 227    CG   CD   OE1  OE2                                  
REMARK 470     PHE P 229    CG   CD1  CD2  CE1  CE2  CZ                         
REMARK 470     ARG P 230    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     GLU P 233    CG   CD   OE1  OE2                                  
REMARK 470     GLU P 234    CG   CD   OE1  OE2                                  
REMARK 470     LYS P 242    CG   CD   CE   NZ                                   
REMARK 470     ARG P 247    CG   CD   NE   CZ   NH1  NH2                        
REMARK 470     LYS P 251    CG   CD   CE   NZ                                   
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: CLOSE CONTACTS IN SAME ASYMMETRIC UNIT                     
REMARK 500                                                                      
REMARK 500 THE FOLLOWING ATOMS ARE IN CLOSE CONTACT.                            
REMARK 500                                                                      
REMARK 500  ATM1  RES C  SSEQI   ATM2  RES C  SSEQI           DISTANCE          
REMARK 500   CD1  LEU K   331     CD2  HIS K   366              2.05            
REMARK 500   OD1  ASP G   364     ND1  HIS G   366              2.09            
REMARK 500   OH   TYR A    64     OE1  GLU A   581              2.10            
REMARK 500   NH1  ARG G    76     OE2  GLU G   362              2.10            
REMARK 500   OD1  ASP K   364     ND1  HIS K   366              2.11            
REMARK 500   OD1  ASP E   395     OG1  THR E   465              2.12            
REMARK 500   OG1  THR E   514     NZ   LYS F   146              2.17            
REMARK 500   OD2  ASP O    63     OG   SER P   169              2.17            
REMARK 500   NH2  ARG G   386     O    PRO G   456              2.18            
REMARK 500   CZ   PHE C   185     NE2  GLN C   217              2.19            
REMARK 500   OH   TYR O   290     O    ARG O   313              2.19            
REMARK 500   OG   SER E   265     NE2  HIS E   574              2.19            
REMARK 500   OG1  THR O   428     OG1  THR O   431              2.19            
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: TORSION ANGLES                                             
REMARK 500                                                                      
REMARK 500 TORSION ANGLES OUTSIDE THE EXPECTED RAMACHANDRAN REGIONS:            
REMARK 500 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 500 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE).                             
REMARK 500                                                                      
REMARK 500 STANDARD TABLE:                                                      
REMARK 500 FORMAT:(10X,I3,1X,A3,1X,A1,I4,A1,4X,F7.2,3X,F7.2)                    
REMARK 500                                                                      
REMARK 500 EXPECTED VALUES: GJ KLEYWEGT AND TA JONES (1996). PHI/PSI-           
REMARK 500 CHOLOGY: RAMACHANDRAN REVISITED. STRUCTURE 4, 1395 - 1400            
REMARK 500                                                                      
REMARK 500  M RES CSSEQI        PSI       PHI                                   
REMARK 500    LEU A  43      -74.33    -80.15                                   
REMARK 500    ASN A  56       26.66     45.39                                   
REMARK 500    ASN A 147       11.69   -140.30                                   
REMARK 500    ASP A 150       40.41    -94.19                                   
REMARK 500    PRO A 184     -102.62    -33.31                                   
REMARK 500    PHE A 185      -54.55    172.88                                   
REMARK 500    GLN A 186       20.01    -69.61                                   
REMARK 500    PRO A 211      -82.67   -108.66                                   
REMARK 500    LEU A 212       75.83   -119.99                                   
REMARK 500    PHE A 214       46.87   -149.03                                   
REMARK 500    SER A 215     -148.16     52.34                                   
REMARK 500    THR A 216       41.15     32.54                                   
REMARK 500    GLN A 217      134.94   -172.45                                   
REMARK 500    ASP A 224       88.45     65.03                                   
REMARK 500    ARG A 225      -75.86    -72.18                                   
REMARK 500    SER A 265     -139.21     51.40                                   
REMARK 500    ASN A 327       39.61    -90.77                                   
REMARK 500    PRO A 352       -7.28    -58.14                                   
REMARK 500    LEU A 385      -74.14   -107.14                                   
REMARK 500    PHE A 433      -61.17   -123.05                                   
REMARK 500    SER A 445       60.94     60.48                                   
REMARK 500    PRO A 469     -179.43    -65.48                                   
REMARK 500    PHE A 483      -29.41   -146.85                                   
REMARK 500    ARG A 489      114.77   -163.55                                   
REMARK 500    TYR A 501      -86.73     -2.26                                   
REMARK 500    TYR A 518       32.90    -80.06                                   
REMARK 500    TYR A 519      -38.61   -149.89                                   
REMARK 500    MET A 560      -74.99    -10.18                                   
REMARK 500    ARG A 565       38.51    -72.92                                   
REMARK 500    VAL A 568       96.47    -68.61                                   
REMARK 500    ASP A 573       64.04    -67.10                                   
REMARK 500    VAL A 587      -60.86   -126.75                                   
REMARK 500    SER A 618      -24.73   -140.76                                   
REMARK 500    GLU A 642       82.97    -67.46                                   
REMARK 500    GLU C  58       33.19    -97.53                                   
REMARK 500    ARG C 123        5.82    -66.91                                   
REMARK 500    ASP C 130      101.87    -58.28                                   
REMARK 500    GLU C 148       75.17    -65.10                                   
REMARK 500    THR C 149      -68.73    -92.97                                   
REMARK 500    LYS C 173      -12.53     69.42                                   
REMARK 500    GLN C 186       73.90    -62.79                                   
REMARK 500    ASN C 187        6.80   -164.07                                   
REMARK 500    PRO C 211     -134.50    -95.52                                   
REMARK 500    LEU C 212       77.84   -104.41                                   
REMARK 500    PRO C 213     -164.47   -105.05                                   
REMARK 500    PHE C 214     -123.54   -139.70                                   
REMARK 500    SER C 215       37.17   -149.63                                   
REMARK 500    LEU C 219      -30.66   -131.33                                   
REMARK 500    ARG C 233       33.06    -87.05                                   
REMARK 500    GLU C 256       42.25   -106.23                                   
REMARK 500                                                                      
REMARK 500 THIS ENTRY HAS     342 RAMACHANDRAN OUTLIERS.                        
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 500                                                                      
REMARK 500 GEOMETRY AND STEREOCHEMISTRY                                         
REMARK 500 SUBTOPIC: NON-CIS, NON-TRANS                                         
REMARK 500                                                                      
REMARK 500 THE FOLLOWING PEPTIDE BONDS DEVIATE SIGNIFICANTLY FROM BOTH          
REMARK 500 CIS AND TRANS CONFORMATION.  CIS BONDS, IF ANY, ARE LISTED           
REMARK 500 ON CISPEP RECORDS.  TRANS IS DEFINED AS 180 +/- 30 AND               
REMARK 500 CIS IS DEFINED AS 0 +/- 30 DEGREES.                                  
REMARK 500                                 MODEL     OMEGA                      
REMARK 500 TYR A   64     ALA A   65                  143.32                    
REMARK 500                                                                      
REMARK 500 REMARK: NULL                                                         
REMARK 620                                                                      
REMARK 620 METAL COORDINATION                                                   
REMARK 620 (M=MODEL NUMBER; RES=RESIDUE NAME; C=CHAIN IDENTIFIER;               
REMARK 620 SSEQ=SEQUENCE NUMBER; I=INSERTION CODE):                             
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              CA A 701  CA                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 ASP A 444   OD2                                                    
REMARK 620 2 ASP A 484   OD1  62.1                                              
REMARK 620 3 GLN A 485   O    73.6  76.5                                        
REMARK 620 4 ASP A 573   OD1 136.4  88.7 133.4                                  
REMARK 620 5 ASP A 573   OD2  91.9  70.2 146.6  45.8                            
REMARK 620 N                    1     2     3     4                             
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              CA C 701  CA                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 ASP C 444   OD1                                                    
REMARK 620 2 ASP C 444   OD2  50.0                                              
REMARK 620 3 ASP C 484   OD1 105.2  75.5                                        
REMARK 620 4 ASP C 573   OD2 165.0 116.3  73.3                                  
REMARK 620 N                    1     2     3                                   
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              CA E 701  CA                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 ASP E 444   OD1                                                    
REMARK 620 2 ASP E 444   OD2  46.8                                              
REMARK 620 3 ASP E 484   OD1  78.6  63.0                                        
REMARK 620 4 GLN E 485   O   109.2  64.0  83.2                                  
REMARK 620 5 ASP E 573   OD1 148.9 135.5  79.5  89.8                            
REMARK 620 N                    1     2     3     4                             
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              CA G 701  CA                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 ASP G 444   OD1                                                    
REMARK 620 2 ASP G 444   OD2  52.5                                              
REMARK 620 3 ASP G 484   OD1  92.9  71.8                                        
REMARK 620 4 ASP G 573   OD1 172.1 120.4  87.2                                  
REMARK 620 N                    1     2     3                                   
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              CA I 701  CA                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 ASP I 444   OD1                                                    
REMARK 620 2 ASP I 444   OD2  50.0                                              
REMARK 620 3 ASP I 484   OD1  84.9  69.8                                        
REMARK 620 4 GLN I 485   O   111.6  62.4  81.6                                  
REMARK 620 5 ASP I 573   OD1 174.0 129.4  89.4  69.4                            
REMARK 620 N                    1     2     3     4                             
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              CA K 701  CA                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 ASP K 444   OD2                                                    
REMARK 620 2 GLN K 485   O    64.8                                              
REMARK 620 3 PRO K 571   O   131.4  93.3                                        
REMARK 620 4 ASP K 573   OD1 118.0  72.6  92.3                                  
REMARK 620 5 ASP K 573   OD2 108.2 104.2 119.4  43.3                            
REMARK 620 N                    1     2     3     4                             
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              CA M 701  CA                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 ASP M 444   OD1                                                    
REMARK 620 2 ASP M 444   OD2  51.1                                              
REMARK 620 3 ASP M 484   OD1  87.8  70.4                                        
REMARK 620 4 ASP M 573   OD2 160.8 116.2  73.4                                  
REMARK 620 N                    1     2     3                                   
REMARK 620                                                                      
REMARK 620 COORDINATION ANGLES FOR:  M RES CSSEQI METAL                         
REMARK 620                              CA O 701  CA                            
REMARK 620 N RES CSSEQI ATOM                                                    
REMARK 620 1 ASP O 444   OD1                                                    
REMARK 620 2 ASP O 444   OD2  51.4                                              
REMARK 620 3 ASP O 484   OD1  92.9  66.8                                        
REMARK 620 4 GLN O 485   O   103.4  56.7  80.7                                  
REMARK 620 5 ASP O 573   OD2 158.3 116.7  65.5  76.6                            
REMARK 620 N                    1     2     3     4                             
DBREF1 8BOZ A    1   658  UNP                  A0A2G9AAY6_ECOLX                 
DBREF2 8BOZ A     A0A2G9AAY6                          1         658             
DBREF1 8BOZ C    1   658  UNP                  A0A2G9AAY6_ECOLX                 
DBREF2 8BOZ C     A0A2G9AAY6                          1         658             
DBREF1 8BOZ B    1   274  UNP                  A0A2G9AAX8_ECOLX                 
DBREF2 8BOZ B     A0A2G9AAX8                          7         280             
DBREF1 8BOZ E    1   658  UNP                  A0A2G9AAY6_ECOLX                 
DBREF2 8BOZ E     A0A2G9AAY6                          1         658             
DBREF1 8BOZ D    1   274  UNP                  A0A2G9AAX8_ECOLX                 
DBREF2 8BOZ D     A0A2G9AAX8                          7         280             
DBREF1 8BOZ F    1   274  UNP                  A0A2G9AAX8_ECOLX                 
DBREF2 8BOZ F     A0A2G9AAX8                          7         280             
DBREF1 8BOZ G    1   658  UNP                  A0A2G9AAY6_ECOLX                 
DBREF2 8BOZ G     A0A2G9AAY6                          1         658             
DBREF1 8BOZ H    1   274  UNP                  A0A2G9AAX8_ECOLX                 
DBREF2 8BOZ H     A0A2G9AAX8                          7         280             
DBREF1 8BOZ I    1   658  UNP                  A0A2G9AAY6_ECOLX                 
DBREF2 8BOZ I     A0A2G9AAY6                          1         658             
DBREF1 8BOZ J    1   274  UNP                  A0A2G9AAX8_ECOLX                 
DBREF2 8BOZ J     A0A2G9AAX8                          7         280             
DBREF1 8BOZ K    1   658  UNP                  A0A2G9AAY6_ECOLX                 
DBREF2 8BOZ K     A0A2G9AAY6                          1         658             
DBREF1 8BOZ L    1   274  UNP                  A0A2G9AAX8_ECOLX                 
DBREF2 8BOZ L     A0A2G9AAX8                          7         280             
DBREF1 8BOZ M    1   658  UNP                  A0A2G9AAY6_ECOLX                 
DBREF2 8BOZ M     A0A2G9AAY6                          1         658             
DBREF1 8BOZ N    1   274  UNP                  A0A2G9AAX8_ECOLX                 
DBREF2 8BOZ N     A0A2G9AAX8                          7         280             
DBREF1 8BOZ O    1   658  UNP                  A0A2G9AAY6_ECOLX                 
DBREF2 8BOZ O     A0A2G9AAY6                          1         658             
DBREF1 8BOZ P    1   274  UNP                  A0A2G9AAX8_ECOLX                 
DBREF2 8BOZ P     A0A2G9AAX8                          7         280             
SEQRES   1 A  658  MET SER THR ASN LYS SER GLU PRO THR ARG LYS VAL ASP          
SEQRES   2 A  658  VAL HIS LEU THR ASP ASN GLY THR PRO PHE ALA TYR SER          
SEQRES   3 A  658  MET THR SER HIS LYS ASN VAL LYS VAL ARG ALA GLU VAL          
SEQRES   4 A  658  GLN PRO PRO LEU GLN LEU PRO GLY LEU ILE ILE PHE VAL          
SEQRES   5 A  658  HIS GLY VAL ASN SER GLU GLY GLU TRP TYR ASP TYR ALA          
SEQRES   6 A  658  GLU ARG SER LEU CYS ALA GLY LEU ASN GLN ARG LEU GLY          
SEQRES   7 A  658  LEU GLU GLY GLU HIS GLY LEU LYS GLU ASN ASN TYR GLU          
SEQRES   8 A  658  GLY GLY PHE PHE VAL ASN SER ASP LYS SER GLU GLY GLY          
SEQRES   9 A  658  TRP GLU HIS THR TYR GLU ILE GLU GLY SER GLN LYS LYS          
SEQRES  10 A  658  TRP VAL SER GLY PRO ARG LYS ILE THR LYS GLY GLY ASP          
SEQRES  11 A  658  GLY ARG SER PRO VAL ILE ARG PHE TYR TRP GLY TYR ARG          
SEQRES  12 A  658  ALA ALA ASP ASN GLU THR ASP THR TYR ALA ILE PRO LEU          
SEQRES  13 A  658  LYS ASN LYS LYS GLY ASP ASN TYR TYR ASP LEU PRO PRO          
SEQRES  14 A  658  GLU SER ARG LYS ALA LYS GLY PRO TRP PHE TRP GLY GLY          
SEQRES  15 A  658  GLY PRO PHE GLN ASN GLY CYS ASN GLN LEU VAL SER LEU          
SEQRES  16 A  658  TRP SER LYS THR GLY PHE ASN ASN ASN PRO SER LEU LEU          
SEQRES  17 A  658  GLY VAL PRO LEU PRO PHE SER THR GLN VAL LEU ASN GLY          
SEQRES  18 A  658  GLU ARG ASP ARG LEU LEU SER ASP ALA PRO PRO ARG HIS          
SEQRES  19 A  658  TYR TYR ALA HIS ALA ALA GLY ARG LEU ALA LYS LEU ILE          
SEQRES  20 A  658  LYS THR ILE ARG ASN GLN HIS PRO GLU ASP THR VAL THR          
SEQRES  21 A  658  VAL LEU SER HIS SER GLN GLY THR MET ILE ALA LEU ALA          
SEQRES  22 A  658  ALA ALA ALA ILE GLU ALA PRO ASP ALA LEU PHE VAL MET          
SEQRES  23 A  658  ASN SER PRO TYR ALA LEU GLU ASN GLU PRO THR THR TYR          
SEQRES  24 A  658  ILE SER TYR PRO ILE LYS GLU ILE ILE SER ARG LYS ALA          
SEQRES  25 A  658  ARG SER ALA THR PHE ALA ASP ILE VAL LYS LYS VAL ALA          
SEQRES  26 A  658  GLU ASN LYS THR ARG LEU LYS GLN GLN GLY CYS ASP ASN          
SEQRES  27 A  658  LEU LEU ALA GLY MET SER SER ASP GLY ASN SER TRP ILE          
SEQRES  28 A  658  PRO GLU GLY LYS THR HIS ASN GLY LEU PRO GLU ARG ASP          
SEQRES  29 A  658  ASN HIS GLY THR THR TRP ILE TYR CYS ASN PRO HIS ASP          
SEQRES  30 A  658  ARG VAL MET GLY SER SER PRO LEU ARG SER ILE GLY TRP          
SEQRES  31 A  658  GLN GLY LEU PRO ASP THR LYS ASP GLY THR PRO HIS THR          
SEQRES  32 A  658  LEU PHE LYS GLN ALA GLY ASP THR LEU TYR VAL ARG ILE          
SEQRES  33 A  658  LEU GLY ARG ASN THR PRO CYS GLY GLY THR PRO THR ALA          
SEQRES  34 A  658  GLN THR HIS PHE SER ASN LEU GLY ASP GLY LYS PRO PHE          
SEQRES  35 A  658  TRP ASP SER THR THR THR LEU LEU GLN ARG ALA THR TRP          
SEQRES  36 A  658  PRO ASP PRO ASP SER GLY GLN THR LEU THR ILE ASN ALA          
SEQRES  37 A  658  PRO GLN VAL PRO GLU PRO LEU THR ALA GLU GLU LEU LYS          
SEQRES  38 A  658  ASN PHE ASP GLN ASP TYR ALA ARG ASP GLU LYS GLN SER          
SEQRES  39 A  658  GLY GLY ALA GLY TYR ALA TYR GLY GLN ILE ASN PRO GLU          
SEQRES  40 A  658  THR LYS LYS PRO VAL ASP THR ASP TYR ARG TYR TYR ILE          
SEQRES  41 A  658  SER LEU TYR GLY TYR PHE ASP ARG LYS MET VAL PRO LYS          
SEQRES  42 A  658  LYS ASP SER GLY TYR TYR GLN SER GLY PRO GLY SER LYS          
SEQRES  43 A  658  GLU ASP ARG VAL LYS TYR GLU LYS GLN SER GLN GLU GLU          
SEQRES  44 A  658  MET LEU GLU GLU VAL ARG THR TYR VAL GLN ARG PRO THR          
SEQRES  45 A  658  ASP HIS SER THR LEU PRO SER ASP GLU ARG PHE MET SER          
SEQRES  46 A  658  ARG VAL VAL ALA TYR ASP LEU PRO ILE GLY TYR CYS TRP          
SEQRES  47 A  658  HIS SER TRP ASP LYS ALA GLY LEU GLU GLU LEU ARG ARG          
SEQRES  48 A  658  GLN ALA ASP TRP LEU GLU SER ASP ASP TYR TYR PHE SER          
SEQRES  49 A  658  GLY LYS LEU THR VAL PRO PRO ILE PRO PRO ALA ILE LYS          
SEQRES  50 A  658  GLN ASP VAL ALA GLU ASP ALA GLU GLN ARG LYS ALA GLU          
SEQRES  51 A  658  GLU LYS ALA ARG LEU ARG ASN VAL                              
SEQRES   1 C  658  MET SER THR ASN LYS SER GLU PRO THR ARG LYS VAL ASP          
SEQRES   2 C  658  VAL HIS LEU THR ASP ASN GLY THR PRO PHE ALA TYR SER          
SEQRES   3 C  658  MET THR SER HIS LYS ASN VAL LYS VAL ARG ALA GLU VAL          
SEQRES   4 C  658  GLN PRO PRO LEU GLN LEU PRO GLY LEU ILE ILE PHE VAL          
SEQRES   5 C  658  HIS GLY VAL ASN SER GLU GLY GLU TRP TYR ASP TYR ALA          
SEQRES   6 C  658  GLU ARG SER LEU CYS ALA GLY LEU ASN GLN ARG LEU GLY          
SEQRES   7 C  658  LEU GLU GLY GLU HIS GLY LEU LYS GLU ASN ASN TYR GLU          
SEQRES   8 C  658  GLY GLY PHE PHE VAL ASN SER ASP LYS SER GLU GLY GLY          
SEQRES   9 C  658  TRP GLU HIS THR TYR GLU ILE GLU GLY SER GLN LYS LYS          
SEQRES  10 C  658  TRP VAL SER GLY PRO ARG LYS ILE THR LYS GLY GLY ASP          
SEQRES  11 C  658  GLY ARG SER PRO VAL ILE ARG PHE TYR TRP GLY TYR ARG          
SEQRES  12 C  658  ALA ALA ASP ASN GLU THR ASP THR TYR ALA ILE PRO LEU          
SEQRES  13 C  658  LYS ASN LYS LYS GLY ASP ASN TYR TYR ASP LEU PRO PRO          
SEQRES  14 C  658  GLU SER ARG LYS ALA LYS GLY PRO TRP PHE TRP GLY GLY          
SEQRES  15 C  658  GLY PRO PHE GLN ASN GLY CYS ASN GLN LEU VAL SER LEU          
SEQRES  16 C  658  TRP SER LYS THR GLY PHE ASN ASN ASN PRO SER LEU LEU          
SEQRES  17 C  658  GLY VAL PRO LEU PRO PHE SER THR GLN VAL LEU ASN GLY          
SEQRES  18 C  658  GLU ARG ASP ARG LEU LEU SER ASP ALA PRO PRO ARG HIS          
SEQRES  19 C  658  TYR TYR ALA HIS ALA ALA GLY ARG LEU ALA LYS LEU ILE          
SEQRES  20 C  658  LYS THR ILE ARG ASN GLN HIS PRO GLU ASP THR VAL THR          
SEQRES  21 C  658  VAL LEU SER HIS SER GLN GLY THR MET ILE ALA LEU ALA          
SEQRES  22 C  658  ALA ALA ALA ILE GLU ALA PRO ASP ALA LEU PHE VAL MET          
SEQRES  23 C  658  ASN SER PRO TYR ALA LEU GLU ASN GLU PRO THR THR TYR          
SEQRES  24 C  658  ILE SER TYR PRO ILE LYS GLU ILE ILE SER ARG LYS ALA          
SEQRES  25 C  658  ARG SER ALA THR PHE ALA ASP ILE VAL LYS LYS VAL ALA          
SEQRES  26 C  658  GLU ASN LYS THR ARG LEU LYS GLN GLN GLY CYS ASP ASN          
SEQRES  27 C  658  LEU LEU ALA GLY MET SER SER ASP GLY ASN SER TRP ILE          
SEQRES  28 C  658  PRO GLU GLY LYS THR HIS ASN GLY LEU PRO GLU ARG ASP          
SEQRES  29 C  658  ASN HIS GLY THR THR TRP ILE TYR CYS ASN PRO HIS ASP          
SEQRES  30 C  658  ARG VAL MET GLY SER SER PRO LEU ARG SER ILE GLY TRP          
SEQRES  31 C  658  GLN GLY LEU PRO ASP THR LYS ASP GLY THR PRO HIS THR          
SEQRES  32 C  658  LEU PHE LYS GLN ALA GLY ASP THR LEU TYR VAL ARG ILE          
SEQRES  33 C  658  LEU GLY ARG ASN THR PRO CYS GLY GLY THR PRO THR ALA          
SEQRES  34 C  658  GLN THR HIS PHE SER ASN LEU GLY ASP GLY LYS PRO PHE          
SEQRES  35 C  658  TRP ASP SER THR THR THR LEU LEU GLN ARG ALA THR TRP          
SEQRES  36 C  658  PRO ASP PRO ASP SER GLY GLN THR LEU THR ILE ASN ALA          
SEQRES  37 C  658  PRO GLN VAL PRO GLU PRO LEU THR ALA GLU GLU LEU LYS          
SEQRES  38 C  658  ASN PHE ASP GLN ASP TYR ALA ARG ASP GLU LYS GLN SER          
SEQRES  39 C  658  GLY GLY ALA GLY TYR ALA TYR GLY GLN ILE ASN PRO GLU          
SEQRES  40 C  658  THR LYS LYS PRO VAL ASP THR ASP TYR ARG TYR TYR ILE          
SEQRES  41 C  658  SER LEU TYR GLY TYR PHE ASP ARG LYS MET VAL PRO LYS          
SEQRES  42 C  658  LYS ASP SER GLY TYR TYR GLN SER GLY PRO GLY SER LYS          
SEQRES  43 C  658  GLU ASP ARG VAL LYS TYR GLU LYS GLN SER GLN GLU GLU          
SEQRES  44 C  658  MET LEU GLU GLU VAL ARG THR TYR VAL GLN ARG PRO THR          
SEQRES  45 C  658  ASP HIS SER THR LEU PRO SER ASP GLU ARG PHE MET SER          
SEQRES  46 C  658  ARG VAL VAL ALA TYR ASP LEU PRO ILE GLY TYR CYS TRP          
SEQRES  47 C  658  HIS SER TRP ASP LYS ALA GLY LEU GLU GLU LEU ARG ARG          
SEQRES  48 C  658  GLN ALA ASP TRP LEU GLU SER ASP ASP TYR TYR PHE SER          
SEQRES  49 C  658  GLY LYS LEU THR VAL PRO PRO ILE PRO PRO ALA ILE LYS          
SEQRES  50 C  658  GLN ASP VAL ALA GLU ASP ALA GLU GLN ARG LYS ALA GLU          
SEQRES  51 C  658  GLU LYS ALA ARG LEU ARG ASN VAL                              
SEQRES   1 B  274  MET LEU LYS GLU TRP MET ILE PHE THR CYS SER LEU LEU          
SEQRES   2 B  274  THR LEU ALA GLY ALA SER LEU PRO LEU SER GLY CYS ILE          
SEQRES   3 B  274  SER ARG GLY GLN GLU SER ILE SER GLU GLY ALA ALA PHE          
SEQRES   4 B  274  GLY ALA GLY ILE LEU ARG GLU PRO GLY ALA THR LYS LYS          
SEQRES   5 B  274  ALA ASP THR LYS ASP LEU ASN VAL PRO PRO PRO VAL TYR          
SEQRES   6 B  274  GLY PRO PRO GLN VAL ILE PHE ARG ILE ASP ASP ASN ARG          
SEQRES   7 B  274  TYR PHE THR LEU GLU ASN TYR THR HIS CYS GLU ASN GLY          
SEQRES   8 B  274  GLN THR PHE TYR ASN ASN LYS ALA LYS ASN ILE HIS VAL          
SEQRES   9 B  274  LYS ILE LEU ASP ALA SER GLY TYR LEU PHE LYS GLY ARG          
SEQRES  10 B  274  LEU PHE TRP LEU SER THR ARG ASP ASP PHE LEU ALA PHE          
SEQRES  11 B  274  PRO ALA THR LEU ASN THR ARG HIS ALA SER CYS MET GLY          
SEQRES  12 B  274  SER ASN LYS GLY CYS MET ASN ALA VAL ILE VAL THR THR          
SEQRES  13 B  274  ASP GLY GLY LYS ARG ARG SER GLY VAL PRO TYR GLY SER          
SEQRES  14 B  274  TYR THR GLN ASN PRO THR GLY ALA THR ARG ASP TYR ASP          
SEQRES  15 B  274  MET LEU VAL MET ASN ASP GLY PHE TYR LEU LEU ARG TYR          
SEQRES  16 B  274  ARG GLY GLY GLN GLY ARG PHE SER PRO VAL ILE LEU ARG          
SEQRES  17 B  274  TRP ILE LEU SER THR GLU ASP SER SER GLY VAL VAL ARG          
SEQRES  18 B  274  SER GLU ASP ALA TYR GLU LEU PHE ARG PRO GLY GLU GLU          
SEQRES  19 B  274  VAL PRO SER THR GLY PHE TYR LYS ILE ASP LEU SER ARG          
SEQRES  20 B  274  PHE TYR PRO LYS ASN ASN VAL MET GLU MET GLN CYS ASP          
SEQRES  21 B  274  ARG THR LEU GLU PRO VAL GLN PRO SER GLU SER LYS ILE          
SEQRES  22 B  274  GLN                                                          
SEQRES   1 E  658  MET SER THR ASN LYS SER GLU PRO THR ARG LYS VAL ASP          
SEQRES   2 E  658  VAL HIS LEU THR ASP ASN GLY THR PRO PHE ALA TYR SER          
SEQRES   3 E  658  MET THR SER HIS LYS ASN VAL LYS VAL ARG ALA GLU VAL          
SEQRES   4 E  658  GLN PRO PRO LEU GLN LEU PRO GLY LEU ILE ILE PHE VAL          
SEQRES   5 E  658  HIS GLY VAL ASN SER GLU GLY GLU TRP TYR ASP TYR ALA          
SEQRES   6 E  658  GLU ARG SER LEU CYS ALA GLY LEU ASN GLN ARG LEU GLY          
SEQRES   7 E  658  LEU GLU GLY GLU HIS GLY LEU LYS GLU ASN ASN TYR GLU          
SEQRES   8 E  658  GLY GLY PHE PHE VAL ASN SER ASP LYS SER GLU GLY GLY          
SEQRES   9 E  658  TRP GLU HIS THR TYR GLU ILE GLU GLY SER GLN LYS LYS          
SEQRES  10 E  658  TRP VAL SER GLY PRO ARG LYS ILE THR LYS GLY GLY ASP          
SEQRES  11 E  658  GLY ARG SER PRO VAL ILE ARG PHE TYR TRP GLY TYR ARG          
SEQRES  12 E  658  ALA ALA ASP ASN GLU THR ASP THR TYR ALA ILE PRO LEU          
SEQRES  13 E  658  LYS ASN LYS LYS GLY ASP ASN TYR TYR ASP LEU PRO PRO          
SEQRES  14 E  658  GLU SER ARG LYS ALA LYS GLY PRO TRP PHE TRP GLY GLY          
SEQRES  15 E  658  GLY PRO PHE GLN ASN GLY CYS ASN GLN LEU VAL SER LEU          
SEQRES  16 E  658  TRP SER LYS THR GLY PHE ASN ASN ASN PRO SER LEU LEU          
SEQRES  17 E  658  GLY VAL PRO LEU PRO PHE SER THR GLN VAL LEU ASN GLY          
SEQRES  18 E  658  GLU ARG ASP ARG LEU LEU SER ASP ALA PRO PRO ARG HIS          
SEQRES  19 E  658  TYR TYR ALA HIS ALA ALA GLY ARG LEU ALA LYS LEU ILE          
SEQRES  20 E  658  LYS THR ILE ARG ASN GLN HIS PRO GLU ASP THR VAL THR          
SEQRES  21 E  658  VAL LEU SER HIS SER GLN GLY THR MET ILE ALA LEU ALA          
SEQRES  22 E  658  ALA ALA ALA ILE GLU ALA PRO ASP ALA LEU PHE VAL MET          
SEQRES  23 E  658  ASN SER PRO TYR ALA LEU GLU ASN GLU PRO THR THR TYR          
SEQRES  24 E  658  ILE SER TYR PRO ILE LYS GLU ILE ILE SER ARG LYS ALA          
SEQRES  25 E  658  ARG SER ALA THR PHE ALA ASP ILE VAL LYS LYS VAL ALA          
SEQRES  26 E  658  GLU ASN LYS THR ARG LEU LYS GLN GLN GLY CYS ASP ASN          
SEQRES  27 E  658  LEU LEU ALA GLY MET SER SER ASP GLY ASN SER TRP ILE          
SEQRES  28 E  658  PRO GLU GLY LYS THR HIS ASN GLY LEU PRO GLU ARG ASP          
SEQRES  29 E  658  ASN HIS GLY THR THR TRP ILE TYR CYS ASN PRO HIS ASP          
SEQRES  30 E  658  ARG VAL MET GLY SER SER PRO LEU ARG SER ILE GLY TRP          
SEQRES  31 E  658  GLN GLY LEU PRO ASP THR LYS ASP GLY THR PRO HIS THR          
SEQRES  32 E  658  LEU PHE LYS GLN ALA GLY ASP THR LEU TYR VAL ARG ILE          
SEQRES  33 E  658  LEU GLY ARG ASN THR PRO CYS GLY GLY THR PRO THR ALA          
SEQRES  34 E  658  GLN THR HIS PHE SER ASN LEU GLY ASP GLY LYS PRO PHE          
SEQRES  35 E  658  TRP ASP SER THR THR THR LEU LEU GLN ARG ALA THR TRP          
SEQRES  36 E  658  PRO ASP PRO ASP SER GLY GLN THR LEU THR ILE ASN ALA          
SEQRES  37 E  658  PRO GLN VAL PRO GLU PRO LEU THR ALA GLU GLU LEU LYS          
SEQRES  38 E  658  ASN PHE ASP GLN ASP TYR ALA ARG ASP GLU LYS GLN SER          
SEQRES  39 E  658  GLY GLY ALA GLY TYR ALA TYR GLY GLN ILE ASN PRO GLU          
SEQRES  40 E  658  THR LYS LYS PRO VAL ASP THR ASP TYR ARG TYR TYR ILE          
SEQRES  41 E  658  SER LEU TYR GLY TYR PHE ASP ARG LYS MET VAL PRO LYS          
SEQRES  42 E  658  LYS ASP SER GLY TYR TYR GLN SER GLY PRO GLY SER LYS          
SEQRES  43 E  658  GLU ASP ARG VAL LYS TYR GLU LYS GLN SER GLN GLU GLU          
SEQRES  44 E  658  MET LEU GLU GLU VAL ARG THR TYR VAL GLN ARG PRO THR          
SEQRES  45 E  658  ASP HIS SER THR LEU PRO SER ASP GLU ARG PHE MET SER          
SEQRES  46 E  658  ARG VAL VAL ALA TYR ASP LEU PRO ILE GLY TYR CYS TRP          
SEQRES  47 E  658  HIS SER TRP ASP LYS ALA GLY LEU GLU GLU LEU ARG ARG          
SEQRES  48 E  658  GLN ALA ASP TRP LEU GLU SER ASP ASP TYR TYR PHE SER          
SEQRES  49 E  658  GLY LYS LEU THR VAL PRO PRO ILE PRO PRO ALA ILE LYS          
SEQRES  50 E  658  GLN ASP VAL ALA GLU ASP ALA GLU GLN ARG LYS ALA GLU          
SEQRES  51 E  658  GLU LYS ALA ARG LEU ARG ASN VAL                              
SEQRES   1 D  274  MET LEU LYS GLU TRP MET ILE PHE THR CYS SER LEU LEU          
SEQRES   2 D  274  THR LEU ALA GLY ALA SER LEU PRO LEU SER GLY CYS ILE          
SEQRES   3 D  274  SER ARG GLY GLN GLU SER ILE SER GLU GLY ALA ALA PHE          
SEQRES   4 D  274  GLY ALA GLY ILE LEU ARG GLU PRO GLY ALA THR LYS LYS          
SEQRES   5 D  274  ALA ASP THR LYS ASP LEU ASN VAL PRO PRO PRO VAL TYR          
SEQRES   6 D  274  GLY PRO PRO GLN VAL ILE PHE ARG ILE ASP ASP ASN ARG          
SEQRES   7 D  274  TYR PHE THR LEU GLU ASN TYR THR HIS CYS GLU ASN GLY          
SEQRES   8 D  274  GLN THR PHE TYR ASN ASN LYS ALA LYS ASN ILE HIS VAL          
SEQRES   9 D  274  LYS ILE LEU ASP ALA SER GLY TYR LEU PHE LYS GLY ARG          
SEQRES  10 D  274  LEU PHE TRP LEU SER THR ARG ASP ASP PHE LEU ALA PHE          
SEQRES  11 D  274  PRO ALA THR LEU ASN THR ARG HIS ALA SER CYS MET GLY          
SEQRES  12 D  274  SER ASN LYS GLY CYS MET ASN ALA VAL ILE VAL THR THR          
SEQRES  13 D  274  ASP GLY GLY LYS ARG ARG SER GLY VAL PRO TYR GLY SER          
SEQRES  14 D  274  TYR THR GLN ASN PRO THR GLY ALA THR ARG ASP TYR ASP          
SEQRES  15 D  274  MET LEU VAL MET ASN ASP GLY PHE TYR LEU LEU ARG TYR          
SEQRES  16 D  274  ARG GLY GLY GLN GLY ARG PHE SER PRO VAL ILE LEU ARG          
SEQRES  17 D  274  TRP ILE LEU SER THR GLU ASP SER SER GLY VAL VAL ARG          
SEQRES  18 D  274  SER GLU ASP ALA TYR GLU LEU PHE ARG PRO GLY GLU GLU          
SEQRES  19 D  274  VAL PRO SER THR GLY PHE TYR LYS ILE ASP LEU SER ARG          
SEQRES  20 D  274  PHE TYR PRO LYS ASN ASN VAL MET GLU MET GLN CYS ASP          
SEQRES  21 D  274  ARG THR LEU GLU PRO VAL GLN PRO SER GLU SER LYS ILE          
SEQRES  22 D  274  GLN                                                          
SEQRES   1 F  274  MET LEU LYS GLU TRP MET ILE PHE THR CYS SER LEU LEU          
SEQRES   2 F  274  THR LEU ALA GLY ALA SER LEU PRO LEU SER GLY CYS ILE          
SEQRES   3 F  274  SER ARG GLY GLN GLU SER ILE SER GLU GLY ALA ALA PHE          
SEQRES   4 F  274  GLY ALA GLY ILE LEU ARG GLU PRO GLY ALA THR LYS LYS          
SEQRES   5 F  274  ALA ASP THR LYS ASP LEU ASN VAL PRO PRO PRO VAL TYR          
SEQRES   6 F  274  GLY PRO PRO GLN VAL ILE PHE ARG ILE ASP ASP ASN ARG          
SEQRES   7 F  274  TYR PHE THR LEU GLU ASN TYR THR HIS CYS GLU ASN GLY          
SEQRES   8 F  274  GLN THR PHE TYR ASN ASN LYS ALA LYS ASN ILE HIS VAL          
SEQRES   9 F  274  LYS ILE LEU ASP ALA SER GLY TYR LEU PHE LYS GLY ARG          
SEQRES  10 F  274  LEU PHE TRP LEU SER THR ARG ASP ASP PHE LEU ALA PHE          
SEQRES  11 F  274  PRO ALA THR LEU ASN THR ARG HIS ALA SER CYS MET GLY          
SEQRES  12 F  274  SER ASN LYS GLY CYS MET ASN ALA VAL ILE VAL THR THR          
SEQRES  13 F  274  ASP GLY GLY LYS ARG ARG SER GLY VAL PRO TYR GLY SER          
SEQRES  14 F  274  TYR THR GLN ASN PRO THR GLY ALA THR ARG ASP TYR ASP          
SEQRES  15 F  274  MET LEU VAL MET ASN ASP GLY PHE TYR LEU LEU ARG TYR          
SEQRES  16 F  274  ARG GLY GLY GLN GLY ARG PHE SER PRO VAL ILE LEU ARG          
SEQRES  17 F  274  TRP ILE LEU SER THR GLU ASP SER SER GLY VAL VAL ARG          
SEQRES  18 F  274  SER GLU ASP ALA TYR GLU LEU PHE ARG PRO GLY GLU GLU          
SEQRES  19 F  274  VAL PRO SER THR GLY PHE TYR LYS ILE ASP LEU SER ARG          
SEQRES  20 F  274  PHE TYR PRO LYS ASN ASN VAL MET GLU MET GLN CYS ASP          
SEQRES  21 F  274  ARG THR LEU GLU PRO VAL GLN PRO SER GLU SER LYS ILE          
SEQRES  22 F  274  GLN                                                          
SEQRES   1 G  658  MET SER THR ASN LYS SER GLU PRO THR ARG LYS VAL ASP          
SEQRES   2 G  658  VAL HIS LEU THR ASP ASN GLY THR PRO PHE ALA TYR SER          
SEQRES   3 G  658  MET THR SER HIS LYS ASN VAL LYS VAL ARG ALA GLU VAL          
SEQRES   4 G  658  GLN PRO PRO LEU GLN LEU PRO GLY LEU ILE ILE PHE VAL          
SEQRES   5 G  658  HIS GLY VAL ASN SER GLU GLY GLU TRP TYR ASP TYR ALA          
SEQRES   6 G  658  GLU ARG SER LEU CYS ALA GLY LEU ASN GLN ARG LEU GLY          
SEQRES   7 G  658  LEU GLU GLY GLU HIS GLY LEU LYS GLU ASN ASN TYR GLU          
SEQRES   8 G  658  GLY GLY PHE PHE VAL ASN SER ASP LYS SER GLU GLY GLY          
SEQRES   9 G  658  TRP GLU HIS THR TYR GLU ILE GLU GLY SER GLN LYS LYS          
SEQRES  10 G  658  TRP VAL SER GLY PRO ARG LYS ILE THR LYS GLY GLY ASP          
SEQRES  11 G  658  GLY ARG SER PRO VAL ILE ARG PHE TYR TRP GLY TYR ARG          
SEQRES  12 G  658  ALA ALA ASP ASN GLU THR ASP THR TYR ALA ILE PRO LEU          
SEQRES  13 G  658  LYS ASN LYS LYS GLY ASP ASN TYR TYR ASP LEU PRO PRO          
SEQRES  14 G  658  GLU SER ARG LYS ALA LYS GLY PRO TRP PHE TRP GLY GLY          
SEQRES  15 G  658  GLY PRO PHE GLN ASN GLY CYS ASN GLN LEU VAL SER LEU          
SEQRES  16 G  658  TRP SER LYS THR GLY PHE ASN ASN ASN PRO SER LEU LEU          
SEQRES  17 G  658  GLY VAL PRO LEU PRO PHE SER THR GLN VAL LEU ASN GLY          
SEQRES  18 G  658  GLU ARG ASP ARG LEU LEU SER ASP ALA PRO PRO ARG HIS          
SEQRES  19 G  658  TYR TYR ALA HIS ALA ALA GLY ARG LEU ALA LYS LEU ILE          
SEQRES  20 G  658  LYS THR ILE ARG ASN GLN HIS PRO GLU ASP THR VAL THR          
SEQRES  21 G  658  VAL LEU SER HIS SER GLN GLY THR MET ILE ALA LEU ALA          
SEQRES  22 G  658  ALA ALA ALA ILE GLU ALA PRO ASP ALA LEU PHE VAL MET          
SEQRES  23 G  658  ASN SER PRO TYR ALA LEU GLU ASN GLU PRO THR THR TYR          
SEQRES  24 G  658  ILE SER TYR PRO ILE LYS GLU ILE ILE SER ARG LYS ALA          
SEQRES  25 G  658  ARG SER ALA THR PHE ALA ASP ILE VAL LYS LYS VAL ALA          
SEQRES  26 G  658  GLU ASN LYS THR ARG LEU LYS GLN GLN GLY CYS ASP ASN          
SEQRES  27 G  658  LEU LEU ALA GLY MET SER SER ASP GLY ASN SER TRP ILE          
SEQRES  28 G  658  PRO GLU GLY LYS THR HIS ASN GLY LEU PRO GLU ARG ASP          
SEQRES  29 G  658  ASN HIS GLY THR THR TRP ILE TYR CYS ASN PRO HIS ASP          
SEQRES  30 G  658  ARG VAL MET GLY SER SER PRO LEU ARG SER ILE GLY TRP          
SEQRES  31 G  658  GLN GLY LEU PRO ASP THR LYS ASP GLY THR PRO HIS THR          
SEQRES  32 G  658  LEU PHE LYS GLN ALA GLY ASP THR LEU TYR VAL ARG ILE          
SEQRES  33 G  658  LEU GLY ARG ASN THR PRO CYS GLY GLY THR PRO THR ALA          
SEQRES  34 G  658  GLN THR HIS PHE SER ASN LEU GLY ASP GLY LYS PRO PHE          
SEQRES  35 G  658  TRP ASP SER THR THR THR LEU LEU GLN ARG ALA THR TRP          
SEQRES  36 G  658  PRO ASP PRO ASP SER GLY GLN THR LEU THR ILE ASN ALA          
SEQRES  37 G  658  PRO GLN VAL PRO GLU PRO LEU THR ALA GLU GLU LEU LYS          
SEQRES  38 G  658  ASN PHE ASP GLN ASP TYR ALA ARG ASP GLU LYS GLN SER          
SEQRES  39 G  658  GLY GLY ALA GLY TYR ALA TYR GLY GLN ILE ASN PRO GLU          
SEQRES  40 G  658  THR LYS LYS PRO VAL ASP THR ASP TYR ARG TYR TYR ILE          
SEQRES  41 G  658  SER LEU TYR GLY TYR PHE ASP ARG LYS MET VAL PRO LYS          
SEQRES  42 G  658  LYS ASP SER GLY TYR TYR GLN SER GLY PRO GLY SER LYS          
SEQRES  43 G  658  GLU ASP ARG VAL LYS TYR GLU LYS GLN SER GLN GLU GLU          
SEQRES  44 G  658  MET LEU GLU GLU VAL ARG THR TYR VAL GLN ARG PRO THR          
SEQRES  45 G  658  ASP HIS SER THR LEU PRO SER ASP GLU ARG PHE MET SER          
SEQRES  46 G  658  ARG VAL VAL ALA TYR ASP LEU PRO ILE GLY TYR CYS TRP          
SEQRES  47 G  658  HIS SER TRP ASP LYS ALA GLY LEU GLU GLU LEU ARG ARG          
SEQRES  48 G  658  GLN ALA ASP TRP LEU GLU SER ASP ASP TYR TYR PHE SER          
SEQRES  49 G  658  GLY LYS LEU THR VAL PRO PRO ILE PRO PRO ALA ILE LYS          
SEQRES  50 G  658  GLN ASP VAL ALA GLU ASP ALA GLU GLN ARG LYS ALA GLU          
SEQRES  51 G  658  GLU LYS ALA ARG LEU ARG ASN VAL                              
SEQRES   1 H  274  MET LEU LYS GLU TRP MET ILE PHE THR CYS SER LEU LEU          
SEQRES   2 H  274  THR LEU ALA GLY ALA SER LEU PRO LEU SER GLY CYS ILE          
SEQRES   3 H  274  SER ARG GLY GLN GLU SER ILE SER GLU GLY ALA ALA PHE          
SEQRES   4 H  274  GLY ALA GLY ILE LEU ARG GLU PRO GLY ALA THR LYS LYS          
SEQRES   5 H  274  ALA ASP THR LYS ASP LEU ASN VAL PRO PRO PRO VAL TYR          
SEQRES   6 H  274  GLY PRO PRO GLN VAL ILE PHE ARG ILE ASP ASP ASN ARG          
SEQRES   7 H  274  TYR PHE THR LEU GLU ASN TYR THR HIS CYS GLU ASN GLY          
SEQRES   8 H  274  GLN THR PHE TYR ASN ASN LYS ALA LYS ASN ILE HIS VAL          
SEQRES   9 H  274  LYS ILE LEU ASP ALA SER GLY TYR LEU PHE LYS GLY ARG          
SEQRES  10 H  274  LEU PHE TRP LEU SER THR ARG ASP ASP PHE LEU ALA PHE          
SEQRES  11 H  274  PRO ALA THR LEU ASN THR ARG HIS ALA SER CYS MET GLY          
SEQRES  12 H  274  SER ASN LYS GLY CYS MET ASN ALA VAL ILE VAL THR THR          
SEQRES  13 H  274  ASP GLY GLY LYS ARG ARG SER GLY VAL PRO TYR GLY SER          
SEQRES  14 H  274  TYR THR GLN ASN PRO THR GLY ALA THR ARG ASP TYR ASP          
SEQRES  15 H  274  MET LEU VAL MET ASN ASP GLY PHE TYR LEU LEU ARG TYR          
SEQRES  16 H  274  ARG GLY GLY GLN GLY ARG PHE SER PRO VAL ILE LEU ARG          
SEQRES  17 H  274  TRP ILE LEU SER THR GLU ASP SER SER GLY VAL VAL ARG          
SEQRES  18 H  274  SER GLU ASP ALA TYR GLU LEU PHE ARG PRO GLY GLU GLU          
SEQRES  19 H  274  VAL PRO SER THR GLY PHE TYR LYS ILE ASP LEU SER ARG          
SEQRES  20 H  274  PHE TYR PRO LYS ASN ASN VAL MET GLU MET GLN CYS ASP          
SEQRES  21 H  274  ARG THR LEU GLU PRO VAL GLN PRO SER GLU SER LYS ILE          
SEQRES  22 H  274  GLN                                                          
SEQRES   1 I  658  MET SER THR ASN LYS SER GLU PRO THR ARG LYS VAL ASP          
SEQRES   2 I  658  VAL HIS LEU THR ASP ASN GLY THR PRO PHE ALA TYR SER          
SEQRES   3 I  658  MET THR SER HIS LYS ASN VAL LYS VAL ARG ALA GLU VAL          
SEQRES   4 I  658  GLN PRO PRO LEU GLN LEU PRO GLY LEU ILE ILE PHE VAL          
SEQRES   5 I  658  HIS GLY VAL ASN SER GLU GLY GLU TRP TYR ASP TYR ALA          
SEQRES   6 I  658  GLU ARG SER LEU CYS ALA GLY LEU ASN GLN ARG LEU GLY          
SEQRES   7 I  658  LEU GLU GLY GLU HIS GLY LEU LYS GLU ASN ASN TYR GLU          
SEQRES   8 I  658  GLY GLY PHE PHE VAL ASN SER ASP LYS SER GLU GLY GLY          
SEQRES   9 I  658  TRP GLU HIS THR TYR GLU ILE GLU GLY SER GLN LYS LYS          
SEQRES  10 I  658  TRP VAL SER GLY PRO ARG LYS ILE THR LYS GLY GLY ASP          
SEQRES  11 I  658  GLY ARG SER PRO VAL ILE ARG PHE TYR TRP GLY TYR ARG          
SEQRES  12 I  658  ALA ALA ASP ASN GLU THR ASP THR TYR ALA ILE PRO LEU          
SEQRES  13 I  658  LYS ASN LYS LYS GLY ASP ASN TYR TYR ASP LEU PRO PRO          
SEQRES  14 I  658  GLU SER ARG LYS ALA LYS GLY PRO TRP PHE TRP GLY GLY          
SEQRES  15 I  658  GLY PRO PHE GLN ASN GLY CYS ASN GLN LEU VAL SER LEU          
SEQRES  16 I  658  TRP SER LYS THR GLY PHE ASN ASN ASN PRO SER LEU LEU          
SEQRES  17 I  658  GLY VAL PRO LEU PRO PHE SER THR GLN VAL LEU ASN GLY          
SEQRES  18 I  658  GLU ARG ASP ARG LEU LEU SER ASP ALA PRO PRO ARG HIS          
SEQRES  19 I  658  TYR TYR ALA HIS ALA ALA GLY ARG LEU ALA LYS LEU ILE          
SEQRES  20 I  658  LYS THR ILE ARG ASN GLN HIS PRO GLU ASP THR VAL THR          
SEQRES  21 I  658  VAL LEU SER HIS SER GLN GLY THR MET ILE ALA LEU ALA          
SEQRES  22 I  658  ALA ALA ALA ILE GLU ALA PRO ASP ALA LEU PHE VAL MET          
SEQRES  23 I  658  ASN SER PRO TYR ALA LEU GLU ASN GLU PRO THR THR TYR          
SEQRES  24 I  658  ILE SER TYR PRO ILE LYS GLU ILE ILE SER ARG LYS ALA          
SEQRES  25 I  658  ARG SER ALA THR PHE ALA ASP ILE VAL LYS LYS VAL ALA          
SEQRES  26 I  658  GLU ASN LYS THR ARG LEU LYS GLN GLN GLY CYS ASP ASN          
SEQRES  27 I  658  LEU LEU ALA GLY MET SER SER ASP GLY ASN SER TRP ILE          
SEQRES  28 I  658  PRO GLU GLY LYS THR HIS ASN GLY LEU PRO GLU ARG ASP          
SEQRES  29 I  658  ASN HIS GLY THR THR TRP ILE TYR CYS ASN PRO HIS ASP          
SEQRES  30 I  658  ARG VAL MET GLY SER SER PRO LEU ARG SER ILE GLY TRP          
SEQRES  31 I  658  GLN GLY LEU PRO ASP THR LYS ASP GLY THR PRO HIS THR          
SEQRES  32 I  658  LEU PHE LYS GLN ALA GLY ASP THR LEU TYR VAL ARG ILE          
SEQRES  33 I  658  LEU GLY ARG ASN THR PRO CYS GLY GLY THR PRO THR ALA          
SEQRES  34 I  658  GLN THR HIS PHE SER ASN LEU GLY ASP GLY LYS PRO PHE          
SEQRES  35 I  658  TRP ASP SER THR THR THR LEU LEU GLN ARG ALA THR TRP          
SEQRES  36 I  658  PRO ASP PRO ASP SER GLY GLN THR LEU THR ILE ASN ALA          
SEQRES  37 I  658  PRO GLN VAL PRO GLU PRO LEU THR ALA GLU GLU LEU LYS          
SEQRES  38 I  658  ASN PHE ASP GLN ASP TYR ALA ARG ASP GLU LYS GLN SER          
SEQRES  39 I  658  GLY GLY ALA GLY TYR ALA TYR GLY GLN ILE ASN PRO GLU          
SEQRES  40 I  658  THR LYS LYS PRO VAL ASP THR ASP TYR ARG TYR TYR ILE          
SEQRES  41 I  658  SER LEU TYR GLY TYR PHE ASP ARG LYS MET VAL PRO LYS          
SEQRES  42 I  658  LYS ASP SER GLY TYR TYR GLN SER GLY PRO GLY SER LYS          
SEQRES  43 I  658  GLU ASP ARG VAL LYS TYR GLU LYS GLN SER GLN GLU GLU          
SEQRES  44 I  658  MET LEU GLU GLU VAL ARG THR TYR VAL GLN ARG PRO THR          
SEQRES  45 I  658  ASP HIS SER THR LEU PRO SER ASP GLU ARG PHE MET SER          
SEQRES  46 I  658  ARG VAL VAL ALA TYR ASP LEU PRO ILE GLY TYR CYS TRP          
SEQRES  47 I  658  HIS SER TRP ASP LYS ALA GLY LEU GLU GLU LEU ARG ARG          
SEQRES  48 I  658  GLN ALA ASP TRP LEU GLU SER ASP ASP TYR TYR PHE SER          
SEQRES  49 I  658  GLY LYS LEU THR VAL PRO PRO ILE PRO PRO ALA ILE LYS          
SEQRES  50 I  658  GLN ASP VAL ALA GLU ASP ALA GLU GLN ARG LYS ALA GLU          
SEQRES  51 I  658  GLU LYS ALA ARG LEU ARG ASN VAL                              
SEQRES   1 J  274  MET LEU LYS GLU TRP MET ILE PHE THR CYS SER LEU LEU          
SEQRES   2 J  274  THR LEU ALA GLY ALA SER LEU PRO LEU SER GLY CYS ILE          
SEQRES   3 J  274  SER ARG GLY GLN GLU SER ILE SER GLU GLY ALA ALA PHE          
SEQRES   4 J  274  GLY ALA GLY ILE LEU ARG GLU PRO GLY ALA THR LYS LYS          
SEQRES   5 J  274  ALA ASP THR LYS ASP LEU ASN VAL PRO PRO PRO VAL TYR          
SEQRES   6 J  274  GLY PRO PRO GLN VAL ILE PHE ARG ILE ASP ASP ASN ARG          
SEQRES   7 J  274  TYR PHE THR LEU GLU ASN TYR THR HIS CYS GLU ASN GLY          
SEQRES   8 J  274  GLN THR PHE TYR ASN ASN LYS ALA LYS ASN ILE HIS VAL          
SEQRES   9 J  274  LYS ILE LEU ASP ALA SER GLY TYR LEU PHE LYS GLY ARG          
SEQRES  10 J  274  LEU PHE TRP LEU SER THR ARG ASP ASP PHE LEU ALA PHE          
SEQRES  11 J  274  PRO ALA THR LEU ASN THR ARG HIS ALA SER CYS MET GLY          
SEQRES  12 J  274  SER ASN LYS GLY CYS MET ASN ALA VAL ILE VAL THR THR          
SEQRES  13 J  274  ASP GLY GLY LYS ARG ARG SER GLY VAL PRO TYR GLY SER          
SEQRES  14 J  274  TYR THR GLN ASN PRO THR GLY ALA THR ARG ASP TYR ASP          
SEQRES  15 J  274  MET LEU VAL MET ASN ASP GLY PHE TYR LEU LEU ARG TYR          
SEQRES  16 J  274  ARG GLY GLY GLN GLY ARG PHE SER PRO VAL ILE LEU ARG          
SEQRES  17 J  274  TRP ILE LEU SER THR GLU ASP SER SER GLY VAL VAL ARG          
SEQRES  18 J  274  SER GLU ASP ALA TYR GLU LEU PHE ARG PRO GLY GLU GLU          
SEQRES  19 J  274  VAL PRO SER THR GLY PHE TYR LYS ILE ASP LEU SER ARG          
SEQRES  20 J  274  PHE TYR PRO LYS ASN ASN VAL MET GLU MET GLN CYS ASP          
SEQRES  21 J  274  ARG THR LEU GLU PRO VAL GLN PRO SER GLU SER LYS ILE          
SEQRES  22 J  274  GLN                                                          
SEQRES   1 K  658  MET SER THR ASN LYS SER GLU PRO THR ARG LYS VAL ASP          
SEQRES   2 K  658  VAL HIS LEU THR ASP ASN GLY THR PRO PHE ALA TYR SER          
SEQRES   3 K  658  MET THR SER HIS LYS ASN VAL LYS VAL ARG ALA GLU VAL          
SEQRES   4 K  658  GLN PRO PRO LEU GLN LEU PRO GLY LEU ILE ILE PHE VAL          
SEQRES   5 K  658  HIS GLY VAL ASN SER GLU GLY GLU TRP TYR ASP TYR ALA          
SEQRES   6 K  658  GLU ARG SER LEU CYS ALA GLY LEU ASN GLN ARG LEU GLY          
SEQRES   7 K  658  LEU GLU GLY GLU HIS GLY LEU LYS GLU ASN ASN TYR GLU          
SEQRES   8 K  658  GLY GLY PHE PHE VAL ASN SER ASP LYS SER GLU GLY GLY          
SEQRES   9 K  658  TRP GLU HIS THR TYR GLU ILE GLU GLY SER GLN LYS LYS          
SEQRES  10 K  658  TRP VAL SER GLY PRO ARG LYS ILE THR LYS GLY GLY ASP          
SEQRES  11 K  658  GLY ARG SER PRO VAL ILE ARG PHE TYR TRP GLY TYR ARG          
SEQRES  12 K  658  ALA ALA ASP ASN GLU THR ASP THR TYR ALA ILE PRO LEU          
SEQRES  13 K  658  LYS ASN LYS LYS GLY ASP ASN TYR TYR ASP LEU PRO PRO          
SEQRES  14 K  658  GLU SER ARG LYS ALA LYS GLY PRO TRP PHE TRP GLY GLY          
SEQRES  15 K  658  GLY PRO PHE GLN ASN GLY CYS ASN GLN LEU VAL SER LEU          
SEQRES  16 K  658  TRP SER LYS THR GLY PHE ASN ASN ASN PRO SER LEU LEU          
SEQRES  17 K  658  GLY VAL PRO LEU PRO PHE SER THR GLN VAL LEU ASN GLY          
SEQRES  18 K  658  GLU ARG ASP ARG LEU LEU SER ASP ALA PRO PRO ARG HIS          
SEQRES  19 K  658  TYR TYR ALA HIS ALA ALA GLY ARG LEU ALA LYS LEU ILE          
SEQRES  20 K  658  LYS THR ILE ARG ASN GLN HIS PRO GLU ASP THR VAL THR          
SEQRES  21 K  658  VAL LEU SER HIS SER GLN GLY THR MET ILE ALA LEU ALA          
SEQRES  22 K  658  ALA ALA ALA ILE GLU ALA PRO ASP ALA LEU PHE VAL MET          
SEQRES  23 K  658  ASN SER PRO TYR ALA LEU GLU ASN GLU PRO THR THR TYR          
SEQRES  24 K  658  ILE SER TYR PRO ILE LYS GLU ILE ILE SER ARG LYS ALA          
SEQRES  25 K  658  ARG SER ALA THR PHE ALA ASP ILE VAL LYS LYS VAL ALA          
SEQRES  26 K  658  GLU ASN LYS THR ARG LEU LYS GLN GLN GLY CYS ASP ASN          
SEQRES  27 K  658  LEU LEU ALA GLY MET SER SER ASP GLY ASN SER TRP ILE          
SEQRES  28 K  658  PRO GLU GLY LYS THR HIS ASN GLY LEU PRO GLU ARG ASP          
SEQRES  29 K  658  ASN HIS GLY THR THR TRP ILE TYR CYS ASN PRO HIS ASP          
SEQRES  30 K  658  ARG VAL MET GLY SER SER PRO LEU ARG SER ILE GLY TRP          
SEQRES  31 K  658  GLN GLY LEU PRO ASP THR LYS ASP GLY THR PRO HIS THR          
SEQRES  32 K  658  LEU PHE LYS GLN ALA GLY ASP THR LEU TYR VAL ARG ILE          
SEQRES  33 K  658  LEU GLY ARG ASN THR PRO CYS GLY GLY THR PRO THR ALA          
SEQRES  34 K  658  GLN THR HIS PHE SER ASN LEU GLY ASP GLY LYS PRO PHE          
SEQRES  35 K  658  TRP ASP SER THR THR THR LEU LEU GLN ARG ALA THR TRP          
SEQRES  36 K  658  PRO ASP PRO ASP SER GLY GLN THR LEU THR ILE ASN ALA          
SEQRES  37 K  658  PRO GLN VAL PRO GLU PRO LEU THR ALA GLU GLU LEU LYS          
SEQRES  38 K  658  ASN PHE ASP GLN ASP TYR ALA ARG ASP GLU LYS GLN SER          
SEQRES  39 K  658  GLY GLY ALA GLY TYR ALA TYR GLY GLN ILE ASN PRO GLU          
SEQRES  40 K  658  THR LYS LYS PRO VAL ASP THR ASP TYR ARG TYR TYR ILE          
SEQRES  41 K  658  SER LEU TYR GLY TYR PHE ASP ARG LYS MET VAL PRO LYS          
SEQRES  42 K  658  LYS ASP SER GLY TYR TYR GLN SER GLY PRO GLY SER LYS          
SEQRES  43 K  658  GLU ASP ARG VAL LYS TYR GLU LYS GLN SER GLN GLU GLU          
SEQRES  44 K  658  MET LEU GLU GLU VAL ARG THR TYR VAL GLN ARG PRO THR          
SEQRES  45 K  658  ASP HIS SER THR LEU PRO SER ASP GLU ARG PHE MET SER          
SEQRES  46 K  658  ARG VAL VAL ALA TYR ASP LEU PRO ILE GLY TYR CYS TRP          
SEQRES  47 K  658  HIS SER TRP ASP LYS ALA GLY LEU GLU GLU LEU ARG ARG          
SEQRES  48 K  658  GLN ALA ASP TRP LEU GLU SER ASP ASP TYR TYR PHE SER          
SEQRES  49 K  658  GLY LYS LEU THR VAL PRO PRO ILE PRO PRO ALA ILE LYS          
SEQRES  50 K  658  GLN ASP VAL ALA GLU ASP ALA GLU GLN ARG LYS ALA GLU          
SEQRES  51 K  658  GLU LYS ALA ARG LEU ARG ASN VAL                              
SEQRES   1 L  274  MET LEU LYS GLU TRP MET ILE PHE THR CYS SER LEU LEU          
SEQRES   2 L  274  THR LEU ALA GLY ALA SER LEU PRO LEU SER GLY CYS ILE          
SEQRES   3 L  274  SER ARG GLY GLN GLU SER ILE SER GLU GLY ALA ALA PHE          
SEQRES   4 L  274  GLY ALA GLY ILE LEU ARG GLU PRO GLY ALA THR LYS LYS          
SEQRES   5 L  274  ALA ASP THR LYS ASP LEU ASN VAL PRO PRO PRO VAL TYR          
SEQRES   6 L  274  GLY PRO PRO GLN VAL ILE PHE ARG ILE ASP ASP ASN ARG          
SEQRES   7 L  274  TYR PHE THR LEU GLU ASN TYR THR HIS CYS GLU ASN GLY          
SEQRES   8 L  274  GLN THR PHE TYR ASN ASN LYS ALA LYS ASN ILE HIS VAL          
SEQRES   9 L  274  LYS ILE LEU ASP ALA SER GLY TYR LEU PHE LYS GLY ARG          
SEQRES  10 L  274  LEU PHE TRP LEU SER THR ARG ASP ASP PHE LEU ALA PHE          
SEQRES  11 L  274  PRO ALA THR LEU ASN THR ARG HIS ALA SER CYS MET GLY          
SEQRES  12 L  274  SER ASN LYS GLY CYS MET ASN ALA VAL ILE VAL THR THR          
SEQRES  13 L  274  ASP GLY GLY LYS ARG ARG SER GLY VAL PRO TYR GLY SER          
SEQRES  14 L  274  TYR THR GLN ASN PRO THR GLY ALA THR ARG ASP TYR ASP          
SEQRES  15 L  274  MET LEU VAL MET ASN ASP GLY PHE TYR LEU LEU ARG TYR          
SEQRES  16 L  274  ARG GLY GLY GLN GLY ARG PHE SER PRO VAL ILE LEU ARG          
SEQRES  17 L  274  TRP ILE LEU SER THR GLU ASP SER SER GLY VAL VAL ARG          
SEQRES  18 L  274  SER GLU ASP ALA TYR GLU LEU PHE ARG PRO GLY GLU GLU          
SEQRES  19 L  274  VAL PRO SER THR GLY PHE TYR LYS ILE ASP LEU SER ARG          
SEQRES  20 L  274  PHE TYR PRO LYS ASN ASN VAL MET GLU MET GLN CYS ASP          
SEQRES  21 L  274  ARG THR LEU GLU PRO VAL GLN PRO SER GLU SER LYS ILE          
SEQRES  22 L  274  GLN                                                          
SEQRES   1 M  658  MET SER THR ASN LYS SER GLU PRO THR ARG LYS VAL ASP          
SEQRES   2 M  658  VAL HIS LEU THR ASP ASN GLY THR PRO PHE ALA TYR SER          
SEQRES   3 M  658  MET THR SER HIS LYS ASN VAL LYS VAL ARG ALA GLU VAL          
SEQRES   4 M  658  GLN PRO PRO LEU GLN LEU PRO GLY LEU ILE ILE PHE VAL          
SEQRES   5 M  658  HIS GLY VAL ASN SER GLU GLY GLU TRP TYR ASP TYR ALA          
SEQRES   6 M  658  GLU ARG SER LEU CYS ALA GLY LEU ASN GLN ARG LEU GLY          
SEQRES   7 M  658  LEU GLU GLY GLU HIS GLY LEU LYS GLU ASN ASN TYR GLU          
SEQRES   8 M  658  GLY GLY PHE PHE VAL ASN SER ASP LYS SER GLU GLY GLY          
SEQRES   9 M  658  TRP GLU HIS THR TYR GLU ILE GLU GLY SER GLN LYS LYS          
SEQRES  10 M  658  TRP VAL SER GLY PRO ARG LYS ILE THR LYS GLY GLY ASP          
SEQRES  11 M  658  GLY ARG SER PRO VAL ILE ARG PHE TYR TRP GLY TYR ARG          
SEQRES  12 M  658  ALA ALA ASP ASN GLU THR ASP THR TYR ALA ILE PRO LEU          
SEQRES  13 M  658  LYS ASN LYS LYS GLY ASP ASN TYR TYR ASP LEU PRO PRO          
SEQRES  14 M  658  GLU SER ARG LYS ALA LYS GLY PRO TRP PHE TRP GLY GLY          
SEQRES  15 M  658  GLY PRO PHE GLN ASN GLY CYS ASN GLN LEU VAL SER LEU          
SEQRES  16 M  658  TRP SER LYS THR GLY PHE ASN ASN ASN PRO SER LEU LEU          
SEQRES  17 M  658  GLY VAL PRO LEU PRO PHE SER THR GLN VAL LEU ASN GLY          
SEQRES  18 M  658  GLU ARG ASP ARG LEU LEU SER ASP ALA PRO PRO ARG HIS          
SEQRES  19 M  658  TYR TYR ALA HIS ALA ALA GLY ARG LEU ALA LYS LEU ILE          
SEQRES  20 M  658  LYS THR ILE ARG ASN GLN HIS PRO GLU ASP THR VAL THR          
SEQRES  21 M  658  VAL LEU SER HIS SER GLN GLY THR MET ILE ALA LEU ALA          
SEQRES  22 M  658  ALA ALA ALA ILE GLU ALA PRO ASP ALA LEU PHE VAL MET          
SEQRES  23 M  658  ASN SER PRO TYR ALA LEU GLU ASN GLU PRO THR THR TYR          
SEQRES  24 M  658  ILE SER TYR PRO ILE LYS GLU ILE ILE SER ARG LYS ALA          
SEQRES  25 M  658  ARG SER ALA THR PHE ALA ASP ILE VAL LYS LYS VAL ALA          
SEQRES  26 M  658  GLU ASN LYS THR ARG LEU LYS GLN GLN GLY CYS ASP ASN          
SEQRES  27 M  658  LEU LEU ALA GLY MET SER SER ASP GLY ASN SER TRP ILE          
SEQRES  28 M  658  PRO GLU GLY LYS THR HIS ASN GLY LEU PRO GLU ARG ASP          
SEQRES  29 M  658  ASN HIS GLY THR THR TRP ILE TYR CYS ASN PRO HIS ASP          
SEQRES  30 M  658  ARG VAL MET GLY SER SER PRO LEU ARG SER ILE GLY TRP          
SEQRES  31 M  658  GLN GLY LEU PRO ASP THR LYS ASP GLY THR PRO HIS THR          
SEQRES  32 M  658  LEU PHE LYS GLN ALA GLY ASP THR LEU TYR VAL ARG ILE          
SEQRES  33 M  658  LEU GLY ARG ASN THR PRO CYS GLY GLY THR PRO THR ALA          
SEQRES  34 M  658  GLN THR HIS PHE SER ASN LEU GLY ASP GLY LYS PRO PHE          
SEQRES  35 M  658  TRP ASP SER THR THR THR LEU LEU GLN ARG ALA THR TRP          
SEQRES  36 M  658  PRO ASP PRO ASP SER GLY GLN THR LEU THR ILE ASN ALA          
SEQRES  37 M  658  PRO GLN VAL PRO GLU PRO LEU THR ALA GLU GLU LEU LYS          
SEQRES  38 M  658  ASN PHE ASP GLN ASP TYR ALA ARG ASP GLU LYS GLN SER          
SEQRES  39 M  658  GLY GLY ALA GLY TYR ALA TYR GLY GLN ILE ASN PRO GLU          
SEQRES  40 M  658  THR LYS LYS PRO VAL ASP THR ASP TYR ARG TYR TYR ILE          
SEQRES  41 M  658  SER LEU TYR GLY TYR PHE ASP ARG LYS MET VAL PRO LYS          
SEQRES  42 M  658  LYS ASP SER GLY TYR TYR GLN SER GLY PRO GLY SER LYS          
SEQRES  43 M  658  GLU ASP ARG VAL LYS TYR GLU LYS GLN SER GLN GLU GLU          
SEQRES  44 M  658  MET LEU GLU GLU VAL ARG THR TYR VAL GLN ARG PRO THR          
SEQRES  45 M  658  ASP HIS SER THR LEU PRO SER ASP GLU ARG PHE MET SER          
SEQRES  46 M  658  ARG VAL VAL ALA TYR ASP LEU PRO ILE GLY TYR CYS TRP          
SEQRES  47 M  658  HIS SER TRP ASP LYS ALA GLY LEU GLU GLU LEU ARG ARG          
SEQRES  48 M  658  GLN ALA ASP TRP LEU GLU SER ASP ASP TYR TYR PHE SER          
SEQRES  49 M  658  GLY LYS LEU THR VAL PRO PRO ILE PRO PRO ALA ILE LYS          
SEQRES  50 M  658  GLN ASP VAL ALA GLU ASP ALA GLU GLN ARG LYS ALA GLU          
SEQRES  51 M  658  GLU LYS ALA ARG LEU ARG ASN VAL                              
SEQRES   1 N  274  MET LEU LYS GLU TRP MET ILE PHE THR CYS SER LEU LEU          
SEQRES   2 N  274  THR LEU ALA GLY ALA SER LEU PRO LEU SER GLY CYS ILE          
SEQRES   3 N  274  SER ARG GLY GLN GLU SER ILE SER GLU GLY ALA ALA PHE          
SEQRES   4 N  274  GLY ALA GLY ILE LEU ARG GLU PRO GLY ALA THR LYS LYS          
SEQRES   5 N  274  ALA ASP THR LYS ASP LEU ASN VAL PRO PRO PRO VAL TYR          
SEQRES   6 N  274  GLY PRO PRO GLN VAL ILE PHE ARG ILE ASP ASP ASN ARG          
SEQRES   7 N  274  TYR PHE THR LEU GLU ASN TYR THR HIS CYS GLU ASN GLY          
SEQRES   8 N  274  GLN THR PHE TYR ASN ASN LYS ALA LYS ASN ILE HIS VAL          
SEQRES   9 N  274  LYS ILE LEU ASP ALA SER GLY TYR LEU PHE LYS GLY ARG          
SEQRES  10 N  274  LEU PHE TRP LEU SER THR ARG ASP ASP PHE LEU ALA PHE          
SEQRES  11 N  274  PRO ALA THR LEU ASN THR ARG HIS ALA SER CYS MET GLY          
SEQRES  12 N  274  SER ASN LYS GLY CYS MET ASN ALA VAL ILE VAL THR THR          
SEQRES  13 N  274  ASP GLY GLY LYS ARG ARG SER GLY VAL PRO TYR GLY SER          
SEQRES  14 N  274  TYR THR GLN ASN PRO THR GLY ALA THR ARG ASP TYR ASP          
SEQRES  15 N  274  MET LEU VAL MET ASN ASP GLY PHE TYR LEU LEU ARG TYR          
SEQRES  16 N  274  ARG GLY GLY GLN GLY ARG PHE SER PRO VAL ILE LEU ARG          
SEQRES  17 N  274  TRP ILE LEU SER THR GLU ASP SER SER GLY VAL VAL ARG          
SEQRES  18 N  274  SER GLU ASP ALA TYR GLU LEU PHE ARG PRO GLY GLU GLU          
SEQRES  19 N  274  VAL PRO SER THR GLY PHE TYR LYS ILE ASP LEU SER ARG          
SEQRES  20 N  274  PHE TYR PRO LYS ASN ASN VAL MET GLU MET GLN CYS ASP          
SEQRES  21 N  274  ARG THR LEU GLU PRO VAL GLN PRO SER GLU SER LYS ILE          
SEQRES  22 N  274  GLN                                                          
SEQRES   1 O  658  MET SER THR ASN LYS SER GLU PRO THR ARG LYS VAL ASP          
SEQRES   2 O  658  VAL HIS LEU THR ASP ASN GLY THR PRO PHE ALA TYR SER          
SEQRES   3 O  658  MET THR SER HIS LYS ASN VAL LYS VAL ARG ALA GLU VAL          
SEQRES   4 O  658  GLN PRO PRO LEU GLN LEU PRO GLY LEU ILE ILE PHE VAL          
SEQRES   5 O  658  HIS GLY VAL ASN SER GLU GLY GLU TRP TYR ASP TYR ALA          
SEQRES   6 O  658  GLU ARG SER LEU CYS ALA GLY LEU ASN GLN ARG LEU GLY          
SEQRES   7 O  658  LEU GLU GLY GLU HIS GLY LEU LYS GLU ASN ASN TYR GLU          
SEQRES   8 O  658  GLY GLY PHE PHE VAL ASN SER ASP LYS SER GLU GLY GLY          
SEQRES   9 O  658  TRP GLU HIS THR TYR GLU ILE GLU GLY SER GLN LYS LYS          
SEQRES  10 O  658  TRP VAL SER GLY PRO ARG LYS ILE THR LYS GLY GLY ASP          
SEQRES  11 O  658  GLY ARG SER PRO VAL ILE ARG PHE TYR TRP GLY TYR ARG          
SEQRES  12 O  658  ALA ALA ASP ASN GLU THR ASP THR TYR ALA ILE PRO LEU          
SEQRES  13 O  658  LYS ASN LYS LYS GLY ASP ASN TYR TYR ASP LEU PRO PRO          
SEQRES  14 O  658  GLU SER ARG LYS ALA LYS GLY PRO TRP PHE TRP GLY GLY          
SEQRES  15 O  658  GLY PRO PHE GLN ASN GLY CYS ASN GLN LEU VAL SER LEU          
SEQRES  16 O  658  TRP SER LYS THR GLY PHE ASN ASN ASN PRO SER LEU LEU          
SEQRES  17 O  658  GLY VAL PRO LEU PRO PHE SER THR GLN VAL LEU ASN GLY          
SEQRES  18 O  658  GLU ARG ASP ARG LEU LEU SER ASP ALA PRO PRO ARG HIS          
SEQRES  19 O  658  TYR TYR ALA HIS ALA ALA GLY ARG LEU ALA LYS LEU ILE          
SEQRES  20 O  658  LYS THR ILE ARG ASN GLN HIS PRO GLU ASP THR VAL THR          
SEQRES  21 O  658  VAL LEU SER HIS SER GLN GLY THR MET ILE ALA LEU ALA          
SEQRES  22 O  658  ALA ALA ALA ILE GLU ALA PRO ASP ALA LEU PHE VAL MET          
SEQRES  23 O  658  ASN SER PRO TYR ALA LEU GLU ASN GLU PRO THR THR TYR          
SEQRES  24 O  658  ILE SER TYR PRO ILE LYS GLU ILE ILE SER ARG LYS ALA          
SEQRES  25 O  658  ARG SER ALA THR PHE ALA ASP ILE VAL LYS LYS VAL ALA          
SEQRES  26 O  658  GLU ASN LYS THR ARG LEU LYS GLN GLN GLY CYS ASP ASN          
SEQRES  27 O  658  LEU LEU ALA GLY MET SER SER ASP GLY ASN SER TRP ILE          
SEQRES  28 O  658  PRO GLU GLY LYS THR HIS ASN GLY LEU PRO GLU ARG ASP          
SEQRES  29 O  658  ASN HIS GLY THR THR TRP ILE TYR CYS ASN PRO HIS ASP          
SEQRES  30 O  658  ARG VAL MET GLY SER SER PRO LEU ARG SER ILE GLY TRP          
SEQRES  31 O  658  GLN GLY LEU PRO ASP THR LYS ASP GLY THR PRO HIS THR          
SEQRES  32 O  658  LEU PHE LYS GLN ALA GLY ASP THR LEU TYR VAL ARG ILE          
SEQRES  33 O  658  LEU GLY ARG ASN THR PRO CYS GLY GLY THR PRO THR ALA          
SEQRES  34 O  658  GLN THR HIS PHE SER ASN LEU GLY ASP GLY LYS PRO PHE          
SEQRES  35 O  658  TRP ASP SER THR THR THR LEU LEU GLN ARG ALA THR TRP          
SEQRES  36 O  658  PRO ASP PRO ASP SER GLY GLN THR LEU THR ILE ASN ALA          
SEQRES  37 O  658  PRO GLN VAL PRO GLU PRO LEU THR ALA GLU GLU LEU LYS          
SEQRES  38 O  658  ASN PHE ASP GLN ASP TYR ALA ARG ASP GLU LYS GLN SER          
SEQRES  39 O  658  GLY GLY ALA GLY TYR ALA TYR GLY GLN ILE ASN PRO GLU          
SEQRES  40 O  658  THR LYS LYS PRO VAL ASP THR ASP TYR ARG TYR TYR ILE          
SEQRES  41 O  658  SER LEU TYR GLY TYR PHE ASP ARG LYS MET VAL PRO LYS          
SEQRES  42 O  658  LYS ASP SER GLY TYR TYR GLN SER GLY PRO GLY SER LYS          
SEQRES  43 O  658  GLU ASP ARG VAL LYS TYR GLU LYS GLN SER GLN GLU GLU          
SEQRES  44 O  658  MET LEU GLU GLU VAL ARG THR TYR VAL GLN ARG PRO THR          
SEQRES  45 O  658  ASP HIS SER THR LEU PRO SER ASP GLU ARG PHE MET SER          
SEQRES  46 O  658  ARG VAL VAL ALA TYR ASP LEU PRO ILE GLY TYR CYS TRP          
SEQRES  47 O  658  HIS SER TRP ASP LYS ALA GLY LEU GLU GLU LEU ARG ARG          
SEQRES  48 O  658  GLN ALA ASP TRP LEU GLU SER ASP ASP TYR TYR PHE SER          
SEQRES  49 O  658  GLY LYS LEU THR VAL PRO PRO ILE PRO PRO ALA ILE LYS          
SEQRES  50 O  658  GLN ASP VAL ALA GLU ASP ALA GLU GLN ARG LYS ALA GLU          
SEQRES  51 O  658  GLU LYS ALA ARG LEU ARG ASN VAL                              
SEQRES   1 P  274  MET LEU LYS GLU TRP MET ILE PHE THR CYS SER LEU LEU          
SEQRES   2 P  274  THR LEU ALA GLY ALA SER LEU PRO LEU SER GLY CYS ILE          
SEQRES   3 P  274  SER ARG GLY GLN GLU SER ILE SER GLU GLY ALA ALA PHE          
SEQRES   4 P  274  GLY ALA GLY ILE LEU ARG GLU PRO GLY ALA THR LYS LYS          
SEQRES   5 P  274  ALA ASP THR LYS ASP LEU ASN VAL PRO PRO PRO VAL TYR          
SEQRES   6 P  274  GLY PRO PRO GLN VAL ILE PHE ARG ILE ASP ASP ASN ARG          
SEQRES   7 P  274  TYR PHE THR LEU GLU ASN TYR THR HIS CYS GLU ASN GLY          
SEQRES   8 P  274  GLN THR PHE TYR ASN ASN LYS ALA LYS ASN ILE HIS VAL          
SEQRES   9 P  274  LYS ILE LEU ASP ALA SER GLY TYR LEU PHE LYS GLY ARG          
SEQRES  10 P  274  LEU PHE TRP LEU SER THR ARG ASP ASP PHE LEU ALA PHE          
SEQRES  11 P  274  PRO ALA THR LEU ASN THR ARG HIS ALA SER CYS MET GLY          
SEQRES  12 P  274  SER ASN LYS GLY CYS MET ASN ALA VAL ILE VAL THR THR          
SEQRES  13 P  274  ASP GLY GLY LYS ARG ARG SER GLY VAL PRO TYR GLY SER          
SEQRES  14 P  274  TYR THR GLN ASN PRO THR GLY ALA THR ARG ASP TYR ASP          
SEQRES  15 P  274  MET LEU VAL MET ASN ASP GLY PHE TYR LEU LEU ARG TYR          
SEQRES  16 P  274  ARG GLY GLY GLN GLY ARG PHE SER PRO VAL ILE LEU ARG          
SEQRES  17 P  274  TRP ILE LEU SER THR GLU ASP SER SER GLY VAL VAL ARG          
SEQRES  18 P  274  SER GLU ASP ALA TYR GLU LEU PHE ARG PRO GLY GLU GLU          
SEQRES  19 P  274  VAL PRO SER THR GLY PHE TYR LYS ILE ASP LEU SER ARG          
SEQRES  20 P  274  PHE TYR PRO LYS ASN ASN VAL MET GLU MET GLN CYS ASP          
SEQRES  21 P  274  ARG THR LEU GLU PRO VAL GLN PRO SER GLU SER LYS ILE          
SEQRES  22 P  274  GLN                                                          
HET     CA  A 701       1                                                       
HET     CA  C 701       1                                                       
HET     CA  E 701       1                                                       
HET     CA  G 701       1                                                       
HET     CA  I 701       1                                                       
HET     CA  K 701       1                                                       
HET     CA  M 701       1                                                       
HET     CA  O 701       1                                                       
HETNAM      CA CALCIUM ION                                                      
FORMUL  17   CA    8(CA 2+)                                                     
HELIX    1 AA1 TRP A   61  LEU A   77  1                                  17    
HELIX    2 AA2 GLU A   80  GLY A   84  5                                   5    
HELIX    3 AA3 GLU A  148  TYR A  152  5                                   5    
HELIX    4 AA4 ASN A  163  LEU A  167  5                                   5    
HELIX    5 AA5 LEU A  192  SER A  197  5                                   6    
HELIX    6 AA6 ARG A  233  HIS A  254  1                                  22    
HELIX    7 AA7 GLN A  266  GLU A  278  1                                  13    
HELIX    8 AA8 GLU A  295  TYR A  302  1                                   8    
HELIX    9 AA9 PRO A  303  ILE A  307  5                                   5    
HELIX   10 AB1 SER A  309  GLU A  326  1                                  18    
HELIX   11 AB2 SER A  387  GLY A  392  1                                   6    
HELIX   12 AB3 THR A  403  GLY A  409  1                                   7    
HELIX   13 AB4 THR A  448  TRP A  455  1                                   8    
HELIX   14 AB5 ASP A  513  ASP A  515  5                                   3    
HELIX   15 AB6 TYR A  516  SER A  521  1                                   6    
HELIX   16 AB7 GLU A  559  VAL A  564  1                                   6    
HELIX   17 AB8 SER A  575  ASP A  580  1                                   6    
HELIX   18 AB9 ASP A  580  VAL A  587  1                                   8    
HELIX   19 AC1 VAL A  587  LEU A  592  1                                   6    
HELIX   20 AC2 ALA A  604  ASP A  614  1                                  11    
HELIX   21 AC3 ASP A  614  ASP A  619  1                                   6    
HELIX   22 AC4 ASP A  619  SER A  624  1                                   6    
HELIX   23 AC5 ASP A  643  ARG A  656  1                                  14    
HELIX   24 AC6 TRP C   61  LEU C   77  1                                  17    
HELIX   25 AC7 GLU C   80  GLY C   84  5                                   5    
HELIX   26 AC8 ASN C  163  LEU C  167  5                                   5    
HELIX   27 AC9 LEU C  192  SER C  197  5                                   6    
HELIX   28 AD1 ARG C  233  HIS C  254  1                                  22    
HELIX   29 AD2 SER C  265  ALA C  276  1                                  12    
HELIX   30 AD3 GLU C  295  TYR C  302  1                                   8    
HELIX   31 AD4 PRO C  303  ILE C  307  5                                   5    
HELIX   32 AD5 SER C  309  GLU C  326  1                                  18    
HELIX   33 AD6 ASN C  327  THR C  329  5                                   3    
HELIX   34 AD7 SER C  387  GLY C  392  1                                   6    
HELIX   35 AD8 HIS C  402  GLY C  409  1                                   8    
HELIX   36 AD9 THR C  448  TRP C  455  1                                   8    
HELIX   37 AE1 ASP C  515  SER C  521  1                                   7    
HELIX   38 AE2 MET C  560  VAL C  564  1                                   5    
HELIX   39 AE3 ASP C  580  VAL C  587  1                                   8    
HELIX   40 AE4 VAL C  587  LEU C  592  1                                   6    
HELIX   41 AE5 ASP C  602  ASP C  614  1                                  13    
HELIX   42 AE6 ASP C  614  ASP C  619  1                                   6    
HELIX   43 AE7 ASP C  619  SER C  624  1                                   6    
HELIX   44 AE8 ASP C  643  ARG C  654  1                                  12    
HELIX   45 AE9 SER B  110  PHE B  114  5                                   5    
HELIX   46 AF1 ASN B  173  ARG B  179  1                                   7    
HELIX   47 AF2 ASP B  260  GLU B  264  5                                   5    
HELIX   48 AF3 TRP E   61  GLY E   78  1                                  18    
HELIX   49 AF4 GLU E   80  GLY E   84  5                                   5    
HELIX   50 AF5 ASN E  163  LEU E  167  5                                   5    
HELIX   51 AF6 PRO E  184  GLY E  188  5                                   5    
HELIX   52 AF7 LEU E  192  SER E  197  5                                   6    
HELIX   53 AF8 ARG E  233  HIS E  254  1                                  22    
HELIX   54 AF9 SER E  265  ALA E  276  1                                  12    
HELIX   55 AG1 GLU E  295  TYR E  302  1                                   8    
HELIX   56 AG2 PRO E  303  ILE E  307  5                                   5    
HELIX   57 AG3 SER E  309  ASN E  327  1                                  19    
HELIX   58 AG4 SER E  387  GLY E  392  1                                   6    
HELIX   59 AG5 HIS E  402  GLY E  409  1                                   8    
HELIX   60 AG6 THR E  448  TRP E  455  1                                   8    
HELIX   61 AG7 ASP E  515  SER E  521  1                                   7    
HELIX   62 AG8 GLU E  559  VAL E  564  1                                   6    
HELIX   63 AG9 SER E  575  ASP E  580  1                                   6    
HELIX   64 AH1 ASP E  580  VAL E  587  1                                   8    
HELIX   65 AH2 VAL E  587  LEU E  592  1                                   6    
HELIX   66 AH3 LYS E  603  ASP E  614  1                                  12    
HELIX   67 AH4 ASP E  619  SER E  624  1                                   6    
HELIX   68 AH5 ASP E  643  ARG E  654  1                                  12    
HELIX   69 AH6 SER D  110  PHE D  114  5                                   5    
HELIX   70 AH7 ASN D  173  ARG D  179  1                                   7    
HELIX   71 AH8 LEU D  245  TYR D  249  5                                   5    
HELIX   72 AH9 ASP D  260  GLU D  264  5                                   5    
HELIX   73 AI1 SER F  110  PHE F  114  5                                   5    
HELIX   74 AI2 ASN F  173  THR F  178  1                                   6    
HELIX   75 AI3 LEU F  245  TYR F  249  5                                   5    
HELIX   76 AI4 ASP F  260  GLU F  264  5                                   5    
HELIX   77 AI5 TRP G   61  LEU G   77  1                                  17    
HELIX   78 AI6 GLU G   80  GLY G   84  5                                   5    
HELIX   79 AI7 ASN G  163  LEU G  167  5                                   5    
HELIX   80 AI8 LEU G  192  SER G  197  5                                   6    
HELIX   81 AI9 ARG G  233  HIS G  254  1                                  22    
HELIX   82 AJ1 SER G  265  GLU G  278  1                                  14    
HELIX   83 AJ2 GLU G  295  TYR G  302  1                                   8    
HELIX   84 AJ3 PRO G  303  ILE G  307  5                                   5    
HELIX   85 AJ4 SER G  309  GLN G  334  1                                  26    
HELIX   86 AJ5 SER G  387  GLY G  392  1                                   6    
HELIX   87 AJ6 HIS G  402  GLY G  409  1                                   8    
HELIX   88 AJ7 THR G  448  TRP G  455  1                                   8    
HELIX   89 AJ8 ASP G  515  ILE G  520  1                                   6    
HELIX   90 AJ9 GLN G  557  VAL G  564  1                                   8    
HELIX   91 AK1 ARG G  565  TYR G  567  5                                   3    
HELIX   92 AK2 SER G  575  ASP G  580  1                                   6    
HELIX   93 AK3 ASP G  580  VAL G  587  1                                   8    
HELIX   94 AK4 VAL G  587  LEU G  592  1                                   6    
HELIX   95 AK5 ASP G  602  ASP G  614  1                                  13    
HELIX   96 AK6 ASP G  614  ASP G  619  1                                   6    
HELIX   97 AK7 ASP G  619  SER G  624  1                                   6    
HELIX   98 AK8 ALA G  644  ALA G  653  1                                  10    
HELIX   99 AK9 SER H  110  PHE H  114  5                                   5    
HELIX  100 AL1 ASN H  173  ARG H  179  1                                   7    
HELIX  101 AL2 LEU H  245  TYR H  249  5                                   5    
HELIX  102 AL3 ASP H  260  GLU H  264  5                                   5    
HELIX  103 AL4 TRP I   61  LEU I   77  1                                  17    
HELIX  104 AL5 GLU I   80  GLY I   84  5                                   5    
HELIX  105 AL6 ASN I  163  LEU I  167  5                                   5    
HELIX  106 AL7 PRO I  184  GLY I  188  5                                   5    
HELIX  107 AL8 GLN I  191  SER I  197  5                                   7    
HELIX  108 AL9 ARG I  233  ASN I  252  1                                  20    
HELIX  109 AM1 SER I  265  GLU I  278  1                                  14    
HELIX  110 AM2 GLU I  295  TYR I  302  1                                   8    
HELIX  111 AM3 PRO I  303  ILE I  307  5                                   5    
HELIX  112 AM4 SER I  309  GLU I  326  1                                  18    
HELIX  113 AM5 ASN I  327  THR I  329  5                                   3    
HELIX  114 AM6 SER I  387  GLY I  392  1                                   6    
HELIX  115 AM7 HIS I  402  GLY I  409  1                                   8    
HELIX  116 AM8 THR I  448  TRP I  455  1                                   8    
HELIX  117 AM9 ASP I  515  ILE I  520  1                                   6    
HELIX  118 AN1 GLU I  558  VAL I  564  1                                   7    
HELIX  119 AN2 SER I  575  ASP I  580  1                                   6    
HELIX  120 AN3 ASP I  580  VAL I  587  1                                   8    
HELIX  121 AN4 VAL I  588  ASP I  591  5                                   4    
HELIX  122 AN5 ASP I  602  ASP I  614  1                                  13    
HELIX  123 AN6 ASP I  614  ASP I  619  1                                   6    
HELIX  124 AN7 ASP I  619  SER I  624  1                                   6    
HELIX  125 AN8 ASP I  643  LEU I  655  1                                  13    
HELIX  126 AN9 SER J  110  PHE J  114  5                                   5    
HELIX  127 AO1 ASN J  173  THR J  178  1                                   6    
HELIX  128 AO2 LEU J  245  TYR J  249  5                                   5    
HELIX  129 AO3 ASP J  260  GLU J  264  5                                   5    
HELIX  130 AO4 TRP K   61  LEU K   77  1                                  17    
HELIX  131 AO5 GLU K   80  GLY K   84  5                                   5    
HELIX  132 AO6 ASN K  163  LEU K  167  5                                   5    
HELIX  133 AO7 LEU K  192  SER K  197  5                                   6    
HELIX  134 AO8 ARG K  233  HIS K  254  1                                  22    
HELIX  135 AO9 SER K  265  GLU K  278  1                                  14    
HELIX  136 AP1 GLU K  295  TYR K  302  1                                   8    
HELIX  137 AP2 PRO K  303  ILE K  307  5                                   5    
HELIX  138 AP3 SER K  309  GLU K  326  1                                  18    
HELIX  139 AP4 ASN K  327  CYS K  336  1                                  10    
HELIX  140 AP5 SER K  387  GLY K  392  1                                   6    
HELIX  141 AP6 HIS K  402  GLY K  409  1                                   8    
HELIX  142 AP7 THR K  448  TRP K  455  1                                   8    
HELIX  143 AP8 ASP K  515  ILE K  520  1                                   6    
HELIX  144 AP9 GLU K  558  VAL K  564  1                                   7    
HELIX  145 AQ1 SER K  575  ASP K  580  1                                   6    
HELIX  146 AQ2 ASP K  580  VAL K  587  1                                   8    
HELIX  147 AQ3 VAL K  587  LEU K  592  1                                   6    
HELIX  148 AQ4 ASP K  602  ASP K  614  1                                  13    
HELIX  149 AQ5 ASP K  614  ASP K  619  1                                   6    
HELIX  150 AQ6 ASP K  619  SER K  624  1                                   6    
HELIX  151 AQ7 ASP K  643  ARG K  654  1                                  12    
HELIX  152 AQ8 SER L  110  PHE L  114  5                                   5    
HELIX  153 AQ9 ASN L  173  ARG L  179  1                                   7    
HELIX  154 AR1 LEU L  245  TYR L  249  5                                   5    
HELIX  155 AR2 ASP L  260  GLU L  264  5                                   5    
HELIX  156 AR3 TRP M   61  GLY M   78  1                                  18    
HELIX  157 AR4 GLU M   80  GLY M   84  5                                   5    
HELIX  158 AR5 ASN M  163  LEU M  167  5                                   5    
HELIX  159 AR6 LEU M  192  SER M  197  5                                   6    
HELIX  160 AR7 HIS M  234  HIS M  254  1                                  21    
HELIX  161 AR8 SER M  265  GLU M  278  1                                  14    
HELIX  162 AR9 GLU M  295  TYR M  302  1                                   8    
HELIX  163 AS1 PRO M  303  ILE M  307  5                                   5    
HELIX  164 AS2 SER M  309  GLU M  326  1                                  18    
HELIX  165 AS3 ASN M  327  THR M  329  5                                   3    
HELIX  166 AS4 SER M  387  GLY M  392  1                                   6    
HELIX  167 AS5 HIS M  402  GLY M  409  1                                   8    
HELIX  168 AS6 THR M  448  TRP M  455  1                                   8    
HELIX  169 AS7 ASP M  515  ILE M  520  1                                   6    
HELIX  170 AS8 GLU M  563  TYR M  567  5                                   5    
HELIX  171 AS9 SER M  575  ASP M  580  1                                   6    
HELIX  172 AT1 ASP M  580  VAL M  587  1                                   8    
HELIX  173 AT2 VAL M  587  LEU M  592  1                                   6    
HELIX  174 AT3 ASP M  602  ASP M  614  1                                  13    
HELIX  175 AT4 ASP M  614  ASP M  619  1                                   6    
HELIX  176 AT5 ASP M  619  SER M  624  1                                   6    
HELIX  177 AT6 ASP M  643  LYS M  652  1                                  10    
HELIX  178 AT7 SER N  110  PHE N  114  5                                   5    
HELIX  179 AT8 ASN N  173  THR N  178  1                                   6    
HELIX  180 AT9 LEU N  245  TYR N  249  5                                   5    
HELIX  181 AU1 ASP N  260  GLU N  264  5                                   5    
HELIX  182 AU2 TRP O   61  LEU O   77  1                                  17    
HELIX  183 AU3 GLU O   80  GLY O   84  5                                   5    
HELIX  184 AU4 PRO O  168  ARG O  172  5                                   5    
HELIX  185 AU5 VAL O  193  SER O  197  5                                   5    
HELIX  186 AU6 ARG O  233  HIS O  254  1                                  22    
HELIX  187 AU7 SER O  265  GLU O  278  1                                  14    
HELIX  188 AU8 GLU O  295  TYR O  302  1                                   8    
HELIX  189 AU9 PRO O  303  ILE O  307  5                                   5    
HELIX  190 AV1 SER O  309  GLU O  326  1                                  18    
HELIX  191 AV2 ASN O  327  THR O  329  5                                   3    
HELIX  192 AV3 SER O  387  GLY O  392  1                                   6    
HELIX  193 AV4 HIS O  402  ALA O  408  1                                   7    
HELIX  194 AV5 THR O  448  TRP O  455  1                                   8    
HELIX  195 AV6 ASP O  515  ILE O  520  1                                   6    
HELIX  196 AV7 GLU O  558  ARG O  565  5                                   8    
HELIX  197 AV8 SER O  575  ASP O  580  1                                   6    
HELIX  198 AV9 ASP O  580  VAL O  587  1                                   8    
HELIX  199 AW1 VAL O  587  LEU O  592  1                                   6    
HELIX  200 AW2 ASP O  602  ASP O  614  1                                  13    
HELIX  201 AW3 ASP O  619  GLY O  625  1                                   7    
HELIX  202 AW4 ASP O  643  ARG O  654  1                                  12    
HELIX  203 AW5 SER P  110  PHE P  114  5                                   5    
HELIX  204 AW6 ASN P  173  ARG P  179  1                                   7    
HELIX  205 AW7 LEU P  245  TYR P  249  5                                   5    
SHEET    1 AA1 6 VAL A 135  ARG A 137  0                                        
SHEET    2 AA1 6 LEU A  48  VAL A  52  1  N  ILE A  49   O  ILE A 136           
SHEET    3 AA1 6 VAL A 259  HIS A 264  1  O  LEU A 262   N  ILE A  50           
SHEET    4 AA1 6 ALA A 282  MET A 286  1  O  PHE A 284   N  SER A 263           
SHEET    5 AA1 6 THR A 368  CYS A 373  1  O  TRP A 370   N  VAL A 285           
SHEET    6 AA1 6 LEU A 412  ILE A 416  1  O  ARG A 415   N  ILE A 371           
SHEET    1 AA2 2 PHE A  94  PHE A  95  0                                        
SHEET    2 AA2 2 TRP A 118  VAL A 119 -1  O  VAL A 119   N  PHE A  94           
SHEET    1 AA3 2 GLY A 141  ARG A 143  0                                        
SHEET    2 AA3 2 PHE A 179  GLY A 181 -1  O  TRP A 180   N  TYR A 142           
SHEET    1 AA4 2 THR A 428  HIS A 432  0                                        
SHEET    2 AA4 2 THR A 463  ILE A 466 -1  O  LEU A 464   N  THR A 431           
SHEET    1 AA5 2 ILE A 504  ASN A 505  0                                        
SHEET    2 AA5 2 LYS A 510  PRO A 511 -1  O  LYS A 510   N  ASN A 505           
SHEET    1 AA6 2 GLN C  44  LEU C  45  0                                        
SHEET    2 AA6 2 HIS C 599  SER C 600 -1  O  HIS C 599   N  LEU C  45           
SHEET    1 AA7 6 VAL C 135  PHE C 138  0                                        
SHEET    2 AA7 6 GLY C  47  VAL C  52  1  N  ILE C  49   O  ILE C 136           
SHEET    3 AA7 6 THR C 258  HIS C 264  1  O  LEU C 262   N  ILE C  50           
SHEET    4 AA7 6 ALA C 282  MET C 286  1  O  PHE C 284   N  SER C 263           
SHEET    5 AA7 6 THR C 369  CYS C 373  1  O  TRP C 370   N  LEU C 283           
SHEET    6 AA7 6 LEU C 412  ILE C 416  1  O  ARG C 415   N  ILE C 371           
SHEET    1 AA8 2 PHE C  94  PHE C  95  0                                        
SHEET    2 AA8 2 TRP C 118  VAL C 119 -1  O  VAL C 119   N  PHE C  94           
SHEET    1 AA9 2 GLY C 141  ARG C 143  0                                        
SHEET    2 AA9 2 PHE C 179  GLY C 181 -1  O  TRP C 180   N  TYR C 142           
SHEET    1 AB1 2 THR C 431  HIS C 432  0                                        
SHEET    2 AB1 2 THR C 463  LEU C 464 -1  O  LEU C 464   N  THR C 431           
SHEET    1 AB2 4 GLN B  69  ARG B  73  0                                        
SHEET    2 AB2 4 ARG B  78  GLU B  83 -1  O  LEU B  82   N  GLN B  69           
SHEET    3 AB2 4 GLN B  92  ASN B  97 -1  O  PHE B  94   N  THR B  81           
SHEET    4 AB2 4 ILE B 102  LEU B 107 -1  O  ILE B 106   N  THR B  93           
SHEET    1 AB3 5 ARG B 117  TRP B 120  0                                        
SHEET    2 AB3 5 TYR B 181  MET B 186  1  O  MET B 183   N  PHE B 119           
SHEET    3 AB3 5 GLY B 189  ARG B 196 -1  O  LEU B 193   N  ASP B 182           
SHEET    4 AB3 5 PHE B 202  LEU B 211 -1  O  LEU B 207   N  LEU B 192           
SHEET    5 AB3 5 VAL B 219  SER B 222 -1  O  VAL B 220   N  ILE B 210           
SHEET    1 AB4 3 LEU B 128  ALA B 132  0                                        
SHEET    2 AB4 3 ALA B 151  THR B 155 -1  O  ILE B 153   N  PHE B 130           
SHEET    3 AB4 3 SER B 163  PRO B 166 -1  O  VAL B 165   N  VAL B 152           
SHEET    1 AB5 6 VAL E 135  ARG E 137  0                                        
SHEET    2 AB5 6 LEU E  48  VAL E  52  1  N  ILE E  49   O  ILE E 136           
SHEET    3 AB5 6 VAL E 259  HIS E 264  1  O  LEU E 262   N  ILE E  50           
SHEET    4 AB5 6 ALA E 282  MET E 286  1  O  MET E 286   N  SER E 263           
SHEET    5 AB5 6 THR E 368  CYS E 373  1  O  TRP E 370   N  LEU E 283           
SHEET    6 AB5 6 LEU E 412  ILE E 416  1  O  TYR E 413   N  ILE E 371           
SHEET    1 AB6 2 PHE E  94  PHE E  95  0                                        
SHEET    2 AB6 2 TRP E 118  VAL E 119 -1  O  VAL E 119   N  PHE E  94           
SHEET    1 AB7 2 GLY E 141  ARG E 143  0                                        
SHEET    2 AB7 2 PHE E 179  GLY E 181 -1  O  TRP E 180   N  TYR E 142           
SHEET    1 AB8 2 LYS E 355  THR E 356  0                                        
SHEET    2 AB8 2 LEU E 360  PRO E 361 -1  O  LEU E 360   N  THR E 356           
SHEET    1 AB9 2 THR E 431  HIS E 432  0                                        
SHEET    2 AB9 2 THR E 463  LEU E 464 -1  O  LEU E 464   N  THR E 431           
SHEET    1 AC1 2 ILE E 504  ASN E 505  0                                        
SHEET    2 AC1 2 LYS E 510  PRO E 511 -1  O  LYS E 510   N  ASN E 505           
SHEET    1 AC2 4 GLN D  69  ARG D  73  0                                        
SHEET    2 AC2 4 ARG D  78  GLU D  83 -1  O  PHE D  80   N  ILE D  71           
SHEET    3 AC2 4 GLN D  92  ASN D  97 -1  O  GLN D  92   N  GLU D  83           
SHEET    4 AC2 4 ILE D 102  LEU D 107 -1  O  ILE D 106   N  THR D  93           
SHEET    1 AC3 5 ARG D 117  TRP D 120  0                                        
SHEET    2 AC3 5 TYR D 181  VAL D 185  1  O  MET D 183   N  ARG D 117           
SHEET    3 AC3 5 GLY D 189  ARG D 196 -1  O  TYR D 191   N  LEU D 184           
SHEET    4 AC3 5 PHE D 202  LEU D 211 -1  O  LEU D 207   N  LEU D 192           
SHEET    5 AC3 5 VAL D 219  SER D 222 -1  O  VAL D 220   N  ILE D 210           
SHEET    1 AC4 3 LEU D 128  ALA D 132  0                                        
SHEET    2 AC4 3 ALA D 151  THR D 155 -1  O  ILE D 153   N  PHE D 130           
SHEET    3 AC4 3 SER D 163  PRO D 166 -1  O  SER D 163   N  VAL D 154           
SHEET    1 AC5 4 GLN F  69  ARG F  73  0                                        
SHEET    2 AC5 4 ARG F  78  GLU F  83 -1  O  PHE F  80   N  PHE F  72           
SHEET    3 AC5 4 GLN F  92  ASN F  97 -1  O  GLN F  92   N  GLU F  83           
SHEET    4 AC5 4 ILE F 102  LEU F 107 -1  O  ILE F 106   N  THR F  93           
SHEET    1 AC6 5 ARG F 117  TRP F 120  0                                        
SHEET    2 AC6 5 TYR F 181  MET F 186  1  O  MET F 183   N  PHE F 119           
SHEET    3 AC6 5 GLY F 189  ARG F 196 -1  O  LEU F 193   N  ASP F 182           
SHEET    4 AC6 5 PHE F 202  LEU F 211 -1  O  TRP F 209   N  PHE F 190           
SHEET    5 AC6 5 VAL F 219  SER F 222 -1  O  VAL F 220   N  ILE F 210           
SHEET    1 AC7 3 LEU F 128  ALA F 132  0                                        
SHEET    2 AC7 3 CYS F 148  THR F 155 -1  O  ILE F 153   N  PHE F 130           
SHEET    3 AC7 3 SER F 163  THR F 171 -1  O  THR F 171   N  CYS F 148           
SHEET    1 AC8 6 VAL G 135  PHE G 138  0                                        
SHEET    2 AC8 6 GLY G  47  VAL G  52  1  N  ILE G  49   O  ILE G 136           
SHEET    3 AC8 6 THR G 258  HIS G 264  1  O  LEU G 262   N  ILE G  50           
SHEET    4 AC8 6 ALA G 282  MET G 286  1  O  PHE G 284   N  VAL G 261           
SHEET    5 AC8 6 THR G 368  CYS G 373  1  O  TYR G 372   N  VAL G 285           
SHEET    6 AC8 6 LEU G 412  ILE G 416  1  O  ARG G 415   N  ILE G 371           
SHEET    1 AC9 2 PHE G  94  PHE G  95  0                                        
SHEET    2 AC9 2 TRP G 118  VAL G 119 -1  O  VAL G 119   N  PHE G  94           
SHEET    1 AD1 2 GLY G 141  ARG G 143  0                                        
SHEET    2 AD1 2 PHE G 179  GLY G 181 -1  O  TRP G 180   N  TYR G 142           
SHEET    1 AD2 2 THR G 431  HIS G 432  0                                        
SHEET    2 AD2 2 THR G 463  LEU G 464 -1  O  LEU G 464   N  THR G 431           
SHEET    1 AD3 2 ILE G 504  ASN G 505  0                                        
SHEET    2 AD3 2 LYS G 510  PRO G 511 -1  O  LYS G 510   N  ASN G 505           
SHEET    1 AD4 4 GLN H  69  ARG H  73  0                                        
SHEET    2 AD4 4 ARG H  78  GLU H  83 -1  O  PHE H  80   N  PHE H  72           
SHEET    3 AD4 4 GLN H  92  ASN H  97 -1  O  PHE H  94   N  THR H  81           
SHEET    4 AD4 4 ILE H 102  LEU H 107 -1  O  LEU H 107   N  THR H  93           
SHEET    1 AD5 5 ARG H 117  TRP H 120  0                                        
SHEET    2 AD5 5 TYR H 181  MET H 186  1  O  MET H 183   N  ARG H 117           
SHEET    3 AD5 5 GLY H 189  TYR H 195 -1  O  GLY H 189   N  MET H 186           
SHEET    4 AD5 5 PRO H 204  LEU H 211 -1  O  LEU H 207   N  LEU H 192           
SHEET    5 AD5 5 VAL H 219  SER H 222 -1  O  VAL H 220   N  ILE H 210           
SHEET    1 AD6 3 LEU H 128  ALA H 132  0                                        
SHEET    2 AD6 3 ALA H 151  THR H 155 -1  O  ALA H 151   N  ALA H 132           
SHEET    3 AD6 3 ARG H 162  PRO H 166 -1  O  SER H 163   N  VAL H 154           
SHEET    1 AD7 6 VAL I 135  ARG I 137  0                                        
SHEET    2 AD7 6 LEU I  48  PHE I  51  1  N  ILE I  49   O  ILE I 136           
SHEET    3 AD7 6 VAL I 259  HIS I 264  1  O  LEU I 262   N  ILE I  50           
SHEET    4 AD7 6 ALA I 282  MET I 286  1  O  MET I 286   N  SER I 263           
SHEET    5 AD7 6 THR I 368  CYS I 373  1  O  TRP I 370   N  VAL I 285           
SHEET    6 AD7 6 LEU I 412  ILE I 416  1  O  TYR I 413   N  ILE I 371           
SHEET    1 AD8 2 PHE I  94  PHE I  95  0                                        
SHEET    2 AD8 2 TRP I 118  VAL I 119 -1  O  VAL I 119   N  PHE I  94           
SHEET    1 AD9 2 GLY I 141  ARG I 143  0                                        
SHEET    2 AD9 2 PHE I 179  GLY I 181 -1  O  TRP I 180   N  TYR I 142           
SHEET    1 AE1 2 THR I 431  HIS I 432  0                                        
SHEET    2 AE1 2 THR I 463  LEU I 464 -1  O  LEU I 464   N  THR I 431           
SHEET    1 AE2 4 GLN J  69  ARG J  73  0                                        
SHEET    2 AE2 4 ARG J  78  GLU J  83 -1  O  LEU J  82   N  GLN J  69           
SHEET    3 AE2 4 GLN J  92  ASN J  97 -1  O  PHE J  94   N  THR J  81           
SHEET    4 AE2 4 ILE J 102  LEU J 107 -1  O  ILE J 102   N  ASN J  97           
SHEET    1 AE3 5 ARG J 117  TRP J 120  0                                        
SHEET    2 AE3 5 TYR J 181  MET J 186  1  O  MET J 183   N  ARG J 117           
SHEET    3 AE3 5 GLY J 189  TYR J 195 -1  O  TYR J 191   N  LEU J 184           
SHEET    4 AE3 5 PRO J 204  LEU J 211 -1  O  TRP J 209   N  PHE J 190           
SHEET    5 AE3 5 VAL J 219  ARG J 221 -1  O  VAL J 220   N  ILE J 210           
SHEET    1 AE4 3 LEU J 128  ALA J 132  0                                        
SHEET    2 AE4 3 ALA J 151  THR J 155 -1  O  THR J 155   N  LEU J 128           
SHEET    3 AE4 3 SER J 163  PRO J 166 -1  O  VAL J 165   N  VAL J 152           
SHEET    1 AE5 6 VAL K 135  PHE K 138  0                                        
SHEET    2 AE5 6 GLY K  47  VAL K  52  1  N  ILE K  49   O  ILE K 136           
SHEET    3 AE5 6 THR K 258  HIS K 264  1  O  LEU K 262   N  ILE K  50           
SHEET    4 AE5 6 ALA K 282  MET K 286  1  O  PHE K 284   N  VAL K 261           
SHEET    5 AE5 6 THR K 369  CYS K 373  1  O  TYR K 372   N  VAL K 285           
SHEET    6 AE5 6 LEU K 412  ILE K 416  1  O  ARG K 415   N  ILE K 371           
SHEET    1 AE6 2 PHE K  94  PHE K  95  0                                        
SHEET    2 AE6 2 TRP K 118  VAL K 119 -1  O  VAL K 119   N  PHE K  94           
SHEET    1 AE7 2 GLY K 141  ARG K 143  0                                        
SHEET    2 AE7 2 PHE K 179  GLY K 181 -1  O  TRP K 180   N  TYR K 142           
SHEET    1 AE8 2 THR K 431  HIS K 432  0                                        
SHEET    2 AE8 2 THR K 463  LEU K 464 -1  O  LEU K 464   N  THR K 431           
SHEET    1 AE9 2 ILE K 504  ASN K 505  0                                        
SHEET    2 AE9 2 LYS K 510  PRO K 511 -1  O  LYS K 510   N  ASN K 505           
SHEET    1 AF1 4 GLN L  69  ARG L  73  0                                        
SHEET    2 AF1 4 ARG L  78  GLU L  83 -1  O  LEU L  82   N  GLN L  69           
SHEET    3 AF1 4 GLN L  92  ASN L  97 -1  O  PHE L  94   N  THR L  81           
SHEET    4 AF1 4 ILE L 102  LEU L 107 -1  O  LEU L 107   N  THR L  93           
SHEET    1 AF2 5 ARG L 117  TRP L 120  0                                        
SHEET    2 AF2 5 TYR L 181  MET L 186  1  O  VAL L 185   N  PHE L 119           
SHEET    3 AF2 5 GLY L 189  ARG L 196 -1  O  LEU L 193   N  ASP L 182           
SHEET    4 AF2 5 PHE L 202  LEU L 211 -1  O  TRP L 209   N  PHE L 190           
SHEET    5 AF2 5 VAL L 219  ARG L 221 -1  O  VAL L 220   N  ILE L 210           
SHEET    1 AF3 3 LEU L 128  ALA L 132  0                                        
SHEET    2 AF3 3 ALA L 151  THR L 155 -1  O  ILE L 153   N  PHE L 130           
SHEET    3 AF3 3 SER L 163  PRO L 166 -1  O  SER L 163   N  VAL L 154           
SHEET    1 AF4 6 VAL M 135  PHE M 138  0                                        
SHEET    2 AF4 6 LEU M  48  VAL M  52  1  N  ILE M  49   O  ILE M 136           
SHEET    3 AF4 6 VAL M 259  HIS M 264  1  O  LEU M 262   N  ILE M  50           
SHEET    4 AF4 6 ALA M 282  MET M 286  1  O  MET M 286   N  SER M 263           
SHEET    5 AF4 6 THR M 368  CYS M 373  1  O  TRP M 370   N  VAL M 285           
SHEET    6 AF4 6 LEU M 412  ILE M 416  1  O  ARG M 415   N  ILE M 371           
SHEET    1 AF5 2 PHE M  94  PHE M  95  0                                        
SHEET    2 AF5 2 TRP M 118  VAL M 119 -1  O  VAL M 119   N  PHE M  94           
SHEET    1 AF6 2 GLY M 141  ARG M 143  0                                        
SHEET    2 AF6 2 PHE M 179  GLY M 181 -1  O  TRP M 180   N  TYR M 142           
SHEET    1 AF7 2 THR M 428  HIS M 432  0                                        
SHEET    2 AF7 2 THR M 463  ILE M 466 -1  O  LEU M 464   N  THR M 431           
SHEET    1 AF8 2 ILE M 504  ASN M 505  0                                        
SHEET    2 AF8 2 LYS M 510  PRO M 511 -1  O  LYS M 510   N  ASN M 505           
SHEET    1 AF9 4 GLN N  69  PHE N  72  0                                        
SHEET    2 AF9 4 ARG N  78  GLU N  83 -1  O  LEU N  82   N  GLN N  69           
SHEET    3 AF9 4 GLN N  92  ASN N  97 -1  O  ASN N  96   N  TYR N  79           
SHEET    4 AF9 4 ILE N 102  LEU N 107 -1  O  LEU N 107   N  THR N  93           
SHEET    1 AG1 5 ARG N 117  TRP N 120  0                                        
SHEET    2 AG1 5 TYR N 181  VAL N 185  1  O  MET N 183   N  ARG N 117           
SHEET    3 AG1 5 GLY N 189  TYR N 195 -1  O  LEU N 193   N  ASP N 182           
SHEET    4 AG1 5 PRO N 204  LEU N 211 -1  O  LEU N 207   N  LEU N 192           
SHEET    5 AG1 5 VAL N 219  SER N 222 -1  O  VAL N 220   N  ILE N 210           
SHEET    1 AG2 3 LEU N 128  ALA N 132  0                                        
SHEET    2 AG2 3 ALA N 151  THR N 155 -1  O  THR N 155   N  LEU N 128           
SHEET    3 AG2 3 SER N 163  PRO N 166 -1  O  VAL N 165   N  VAL N 152           
SHEET    1 AG3 6 VAL O 135  PHE O 138  0                                        
SHEET    2 AG3 6 LEU O  48  VAL O  52  1  N  ILE O  49   O  ILE O 136           
SHEET    3 AG3 6 VAL O 259  SER O 263  1  O  LEU O 262   N  ILE O  50           
SHEET    4 AG3 6 ALA O 282  MET O 286  1  O  ALA O 282   N  VAL O 261           
SHEET    5 AG3 6 THR O 369  CYS O 373  1  O  TRP O 370   N  LEU O 283           
SHEET    6 AG3 6 LEU O 412  ILE O 416  1  O  TYR O 413   N  ILE O 371           
SHEET    1 AG4 2 PHE O  94  PHE O  95  0                                        
SHEET    2 AG4 2 TRP O 118  VAL O 119 -1  O  VAL O 119   N  PHE O  94           
SHEET    1 AG5 2 GLY O 141  ARG O 143  0                                        
SHEET    2 AG5 2 PHE O 179  GLY O 181 -1  O  TRP O 180   N  TYR O 142           
SHEET    1 AG6 2 THR O 428  HIS O 432  0                                        
SHEET    2 AG6 2 THR O 463  ILE O 466 -1  O  LEU O 464   N  THR O 431           
SHEET    1 AG7 4 GLN P  69  ARG P  73  0                                        
SHEET    2 AG7 4 ARG P  78  GLU P  83 -1  O  PHE P  80   N  ILE P  71           
SHEET    3 AG7 4 GLN P  92  ASN P  97 -1  O  PHE P  94   N  THR P  81           
SHEET    4 AG7 4 ILE P 102  LEU P 107 -1  O  VAL P 104   N  TYR P  95           
SHEET    1 AG8 5 ARG P 117  TRP P 120  0                                        
SHEET    2 AG8 5 TYR P 181  MET P 186  1  O  MET P 183   N  ARG P 117           
SHEET    3 AG8 5 GLY P 189  TYR P 195 -1  O  TYR P 191   N  LEU P 184           
SHEET    4 AG8 5 PRO P 204  LEU P 211 -1  O  VAL P 205   N  ARG P 194           
SHEET    5 AG8 5 VAL P 219  ARG P 221 -1  O  VAL P 220   N  ILE P 210           
SHEET    1 AG9 3 LEU P 128  ALA P 132  0                                        
SHEET    2 AG9 3 ALA P 151  THR P 155 -1  O  ILE P 153   N  PHE P 130           
SHEET    3 AG9 3 SER P 163  PRO P 166 -1  O  SER P 163   N  VAL P 154           
SSBOND   1 CYS B   88    CYS B  259                          1555   1555  2.03  
SSBOND   2 CYS B  141    CYS B  148                          1555   1555  2.03  
SSBOND   3 CYS D   88    CYS D  259                          1555   1555  2.03  
SSBOND   4 CYS D  141    CYS D  148                          1555   1555  2.03  
SSBOND   5 CYS F   88    CYS F  259                          1555   1555  2.03  
SSBOND   6 CYS F  141    CYS F  148                          1555   1555  2.03  
SSBOND   7 CYS H   88    CYS H  259                          1555   1555  2.03  
SSBOND   8 CYS H  141    CYS H  148                          1555   1555  2.03  
SSBOND   9 CYS J   88    CYS J  259                          1555   1555  2.03  
SSBOND  10 CYS J  141    CYS J  148                          1555   1555  2.03  
SSBOND  11 CYS L   88    CYS L  259                          1555   1555  2.03  
SSBOND  12 CYS L  141    CYS L  148                          1555   1555  2.03  
SSBOND  13 CYS N   88    CYS N  259                          1555   1555  2.03  
SSBOND  14 CYS N  141    CYS N  148                          1555   1555  2.03  
SSBOND  15 CYS P   88    CYS P  259                          1555   1555  2.03  
SSBOND  16 CYS P  141    CYS P  148                          1555   1555  2.03  
LINK         OD2 ASP A 444                CA    CA A 701     1555   1555  2.32  
LINK         OD1 ASP A 484                CA    CA A 701     1555   1555  2.99  
LINK         O   GLN A 485                CA    CA A 701     1555   1555  2.38  
LINK         OD1 ASP A 573                CA    CA A 701     1555   1555  3.06  
LINK         OD2 ASP A 573                CA    CA A 701     1555   1555  2.32  
LINK         OD1 ASP C 444                CA    CA C 701     1555   1555  2.76  
LINK         OD2 ASP C 444                CA    CA C 701     1555   1555  2.35  
LINK         OD1 ASP C 484                CA    CA C 701     1555   1555  2.39  
LINK         OD2 ASP C 573                CA    CA C 701     1555   1555  2.45  
LINK         OD1 ASP E 444                CA    CA E 701     1555   1555  2.94  
LINK         OD2 ASP E 444                CA    CA E 701     1555   1555  2.47  
LINK         OD1 ASP E 484                CA    CA E 701     1555   1555  2.81  
LINK         O   GLN E 485                CA    CA E 701     1555   1555  2.70  
LINK         OD1 ASP E 573                CA    CA E 701     1555   1555  2.43  
LINK         OD1 ASP G 444                CA    CA G 701     1555   1555  2.59  
LINK         OD2 ASP G 444                CA    CA G 701     1555   1555  2.35  
LINK         OD1 ASP G 484                CA    CA G 701     1555   1555  2.51  
LINK         OD1 ASP G 573                CA    CA G 701     1555   1555  2.31  
LINK         OD1 ASP I 444                CA    CA I 701     1555   1555  2.75  
LINK         OD2 ASP I 444                CA    CA I 701     1555   1555  2.38  
LINK         OD1 ASP I 484                CA    CA I 701     1555   1555  2.46  
LINK         O   GLN I 485                CA    CA I 701     1555   1555  2.97  
LINK         OD1 ASP I 573                CA    CA I 701     1555   1555  2.35  
LINK         OD2 ASP K 444                CA    CA K 701     1555   1555  2.27  
LINK         O   GLN K 485                CA    CA K 701     1555   1555  2.66  
LINK         O   PRO K 571                CA    CA K 701     1555   1555  2.95  
LINK         OD1 ASP K 573                CA    CA K 701     1555   1555  3.20  
LINK         OD2 ASP K 573                CA    CA K 701     1555   1555  2.28  
LINK         OD1 ASP M 444                CA    CA M 701     1555   1555  2.68  
LINK         OD2 ASP M 444                CA    CA M 701     1555   1555  2.36  
LINK         OD1 ASP M 484                CA    CA M 701     1555   1555  2.63  
LINK         OD2 ASP M 573                CA    CA M 701     1555   1555  2.50  
LINK         OD1 ASP O 444                CA    CA O 701     1555   1555  2.53  
LINK         OD2 ASP O 444                CA    CA O 701     1555   1555  2.52  
LINK         OD1 ASP O 484                CA    CA O 701     1555   1555  2.78  
LINK         O   GLN O 485                CA    CA O 701     1555   1555  3.12  
LINK         OD2 ASP O 573                CA    CA O 701     1555   1555  2.44  
CISPEP   1 LYS C  175    GLY C  176          0        -2.07                     
CISPEP   2 TYR B  241    LYS B  242          0        -4.28                     
CISPEP   3 LYS E  175    GLY E  176          0        -2.21                     
CISPEP   4 LYS G  175    GLY G  176          0        -1.76                     
CISPEP   5 LYS I  175    GLY I  176          0        -3.60                     
CISPEP   6 LYS K  175    GLY K  176          0        -1.01                     
CISPEP   7 LYS M  175    GLY M  176          0         0.33                     
CISPEP   8 LYS O  175    GLY O  176          0         1.38                     
CRYST1   67.860  449.070  116.230  90.00  93.18  90.00 P 1 21 1     16          
ORIGX1      1.000000  0.000000  0.000000        0.00000                         
ORIGX2      0.000000  1.000000  0.000000        0.00000                         
ORIGX3      0.000000  0.000000  1.000000        0.00000                         
SCALE1      0.014736  0.000000  0.000819        0.00000                         
SCALE2      0.000000  0.002227  0.000000        0.00000                         
SCALE3      0.000000  0.000000  0.008617        0.00000                         
TER    4073      ARG A 656                                                      
TER    8063      ARG C 654                                                      
TER    9719      LYS B 272                                                      
TER   13847      ARG E 654                                                      
TER   15463      PRO D 268                                                      
TER   17092      GLU F 270                                                      
TER   21236      ALA G 653                                                      
TER   22846      SER H 269                                                      
TER   26889      ARG I 656                                                      
TER   28541      GLN J 274                                                      
TER   32621      ARG K 654                                                      
TER   34208      GLN L 267                                                      
TER   38187      ALA M 653                                                      
TER   39768      VAL N 266                                                      
TER   43669      ARG O 654                                                      
TER   45242      PRO P 268                                                      
MASTER     2565    0    8  205  206    0    0    645234   16   82  584          
END                                                                             

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Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
For technical information about these pages see:
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