Structure Report for: 6II2
6II2 | Name | Crystal structure of alpha-beta hydrolase (ABH) and Makes Caterpillars Floppy (MCF)-Like effectors of Vibrio vulnificus MO6-24/O |
| Gene_locus | vibvy-q7mdk6 |
| Paper | Lee_2019_Proc.Natl.Acad.Sci.U.S.A_116_18031 |
| PDB_file | 6ii2-pdb |
| Family | 6_AlphaBeta_hydrolase |
| Comment | Lee, Y., Kim, B.S., Choi, S., Lee, E.Y., Park, S., Hwang, J., Kwon, Y., Hyung, J., Lee, C., Eom, S.H., Kim, M.H. Precursor of a multifunctional toxin that causes destruction of the actin cytoskeleton by covalent cross-linking of actin and inactivation of Rho GTPases when translocated into the host cytoplasm. Upon translocation into the host cell, undergoes autoprocessing in cis mediated by the peptidase C80 domain (also named CPD domain). One of the liberated protein is an alpha/beta hydrolase which has a phosphatidylinositol-3-phosphate-specific phospholipase A1 activity which inhibits autophagy and endosomal trafficking |
| Revelation_date | 07-Aug-2019 |
| News | AUGUST-07-2019 |
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