Structure

Tree Display

AceDB Schema

XML Display

Feedback

Structure Report for: 6II2

Name Class
6II2NameCrystal structure of alpha-beta hydrolase (ABH) and Makes Caterpillars Floppy (MCF)-Like effectors of Vibrio vulnificus MO6-24/O
Gene_locusvibvy-q7mdk6
PaperLee_2019_Proc.Natl.Acad.Sci.U.S.A_116_18031
PDB_file6ii2-pdb
Family6_AlphaBeta_hydrolase
CommentLee, Y., Kim, B.S., Choi, S., Lee, E.Y., Park, S., Hwang, J., Kwon, Y., Hyung, J., Lee, C., Eom, S.H., Kim, M.H.
Precursor of a multifunctional toxin that causes destruction of the actin
cytoskeleton by covalent cross-linking of actin and inactivation of Rho GTPases
when translocated into the host cytoplasm. Upon translocation into the host
cell, undergoes autoprocessing in cis mediated by the peptidase C80 domain
(also named CPD domain). One of the liberated protein is an alpha/beta hydrolase
which has a phosphatidylinositol-3-phosphate-specific phospholipase A1
activity which inhibits autophagy and endosomal trafficking
Revelation_date07-Aug-2019
NewsAUGUST-07-2019

Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
For technical information about these pages see:
ESTHER Home Page and ACEDB Home Page
AcePerl Lincoln Stein Home Page
webmaster

Acknowledgements and disclaimer