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Structure Report for: 5HQ3

Name Class
5HQ3NameHuman acetylcholinesterase designed variant expressed in bacteria
Gene_locushuman-ACHE
PaperGoldenzweig_2016_Mol.Cell_63_337
MutationV12T_human-ACHE
K23T_human-ACHE
M42V_human-ACHE
L48R_human-ACHE
V60W_human-ACHE
S67N_human-ACHE
E91N_human-ACHE
T109K_human-ACHE
S110N_human-ACHE
T112A_human-ACHE
L115M_human-ACHE
A127S_human-ACHE
Q140R_human-ACHE
A141T_human-ACHE
T144V_human-ACHE
V187I_human-ACHE
V226I_human-ACHE
G234A_human-ACHE
T238Y_human-ACHE
G240S_human-ACHE
M241R_human-ACHE
G242E_human-ACHE
T249L_human-ACHE
H253K_human-ACHE
T275N_human-ACHE
A278P_human-ACHE
V280E_human-ACHE
S309P_human-ACHE
A318N_human-ACHE
H322K_human-ACHE
V331N_human-ACHE
Q325D_human-ACHE
A357E_human-ACHE
A361E_human-ACHE
V378I_human-ACHE
R393K_human-ACHE
L394N_human-ACHE
E396D_human-ACHE
V408I_human-ACHE
L414F_human-ACHE
G416Q_human-ACHE
L418Y_human-ACHE
Q421N_human-ACHE
A434S_human-ACHE
S438P_human-ACHE
L441E_human-ACHE
A467K_human-ACHE
Q474R_human-ACHE
G506D_human-ACHE
A507E_human-ACHE
Q509K_human-ACHE
PDB_file5hq3-pdb
InhibitorVX
FamilyACHE
CommentGoldenzweig, A., Goldsmith, M., Hill, S.E., Gertman, O., Laurino, P.,
Ashani, Y., Dym, O., Albeck, S., Unger, T., Prilusky, J., Lieberman, R.L.,
Aharoni, A., Silman, I., Sussman, J.L., Tawfik, D.S., Fleishman, S.J. (51 substitutions)
(V12T,K23T,M42V,L48R,V60W,S67N,E91N,T109K,S110N,T112A,L115M,A127S,Q140R,A141T,
T144V,V187I,V226I,G234A,T238Y,G240S,M241R,G242E,T249L,H253K,T275N,A278P,
V280E,S309P,A318N,H322K,V331N,Q325D,A357E,A361E,V378I,R393K,L394N,E396D,V408I,
L414F,G416Q,L418Y,Q421N,A434S,S438P,L441E,A467K,Q474R,G506D,A507E,Q509K)
>5HQ3
MEGREDAELLVTTRGGRLRGIRLTTPGGPVSAFLGIPFAEPPVGPRRFRPPEPKQPWSGVWDATTFQNVCYQYVDTLYPG
FEGTEMWNPNRNLSEDCLYLNVWTPYPRPKNPAPVMVWIYGGGFYSGSSSLDVYDGRFLVRTERVVLVSMNYRVGAFGFL
ALPGSREAPGNVGLLDQRLALQWVQENIAAFGGDPTSVTLFGESAGAASVGMHLLSPPSRGLFHRAILQSGAPNAPWAYV
SREEARRRALQLAKLVGCPPGGTGGNDTELVACLRNRPPQELVNHEWHVLPQESVFRFSFVPVVDGDFLPDTPEALINNG
DFKGLDVLVGVNKDEGSYFLVYGAPGFSKDNESLISREEFLEGVRVGVPQVSDLAAEAIVLHYTDWLHPEDPAKNRDALS
DVVGDHNVICPVAQFAQRYAANGARVYAYVFEHRSSTLPWPEWMGVPHGYEIEFIFGIPLDPSRNYTKEEKIFARRLMRY
WANFARTGDPNEPRDPKAPQWPPYTADEQKYVSLDLRPLEVRRGLRAQACAFWNRFLPKLLSATDTLD
Revelation_date27-Jul-2016
NewsJULY-27-2016

Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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