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Inhibitor Report for: 2-Chloroprocaine

Name Class
2-ChloroprocaineTypeLocal anesthetic
Not A/B H target
Other_Name (10)
Chemical_Nomenclature4-amino-2-chlorobenzoic acid 2-diethylaminoethyl ester hydrochlorid
FormulaC13H19ClN2O2
CAS_number3858-89-7
MW270.755
PaperHenderson_1993_J.Clin.Anesth_5_129
Maes_2016_Acta.Anaesthesiologica.Scandinavica_60_642
Lockridge_1990_Pharmacol.Ther_47_35
CommentLocal anesthetic, the hydrochloride is Nesacaine
Chloroprocaine Hydrochloride is a synthetic, aminoester, local, anesthetic agent. Chloroprocaine hydrochloride acts by inhibiting sodium influx through binding to specific membrane sodium ion channels in the neuronal cell membranes, restricting sodium permeability, and blocking nerve impulse conduction. This leads to a loss of sensation. Chloroprocaine hydrochloride is short-acting due to rapid hydrolysis by pseudocholinesterase into para-aminobenzoic acid in plasma. Chloroprocaine has a significantly shorter duration of action than lidocaine and is significantly less toxic.
Gene_locushuman-BCHE
CID8612
441348
19727
FamilyBCHE
InChIKeyVDANGULDQQJODZ-UHFFFAOYSA-N
SZKQYDBPUCZLRX-UHFFFAOYSA-N
CanonicalSMILESCCN(CC)CCOC(=O)C1=C(C=C(C=C1)N)Cl
CC[NH+](CC)CCOC(=O)C1=C(C=C(C=C1)N)Cl.[Cl-]
CCN(CC)CCOC(=O)C1=C(C=C(C=C1)N)Cl.Cl
InChIInChI=1S/C13H19ClN2O2/c1-3-16(4-2)7-8-18-13(17)11-6-5-10(15)9-12(11)14/h5-6,9H,3-4,7-8,15H2,1-2H3
InChI=1S/C13H19ClN2O2.ClH/c1-3-16(4-2)7-8-18-13(17)11-6-5-10(15)9-12(11)14;/h5-6,9H,3-4,7-8,15H2,1-2H3;1H
IupharLig7145
WikipediaChloroprocaine

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Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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