Torpedo_number Report for: 572

chick-ACHE

Mutation	Kin.	Type	Evaluation system	Effect	Reference
C764A		sdm	Subunit assembly	Decrease in content of the multimeric forms, small amounts of dimer detectable	Gough_1995_J.Neurochem_65_2734
C764X		sdm	Subunit assembly	Decrease in content of the multimeric forms, small amounts of dimer detectable	Gough_1995_J.Neurochem_65_2734

drome-ACHE

Mutation	Kin.	Type	Evaluation system	Effect	Reference
C615R		sdm	Subunit assembly	C 615 involved in intersubunit linkage	Mutero_1992_J.Biol.Chem_267_1695

human-ACHE : (kinetic parameters)

Mutation	Kin.	Type	Evaluation system	Effect	Reference
C580A	kin	sdm	Subunit assembly	dimerization deficient mutant are secreted in medium efficiently and undergo terminal glycosylation	Kerem_1993_J.Biol.Chem_268_180, Kronman_1995_5th.ChE.Meeting.Madras__293, Velan_1994_J.Biol.Chem_269_22719, Velan_1995_5th.ChE.Meeting.Madras__269
C580K		sdm	Intracellular retention	Biosynthesis,Intracellular retention	Velan_1994_J.Biol.Chem_269_22719, Kronman_1995_5th.ChE.Meeting.Madras__293
C580S		sdm	Subunit assembly	Dimerization deficient mutant	Fischer_1993_Cell.Mol.Neurobiol_13_25, Fischer_1995_Biotechnol.App.Biochem_21_295

human-BCHE

Mutation	Kin.	Type	Evaluation system	Effect	Reference
C571A		sdm	Subunit assembly	Elimination of interchain disulfide bond, decreases heat stability but preserves tetrameric structure	Blong_1995_5th.ChE.Meeting.Madras__129, Blong_1997_Biochem.J_327_747
W543A/ F547A/ W550A/ Y553A/ W557A/ F561A/ Y564A/ C571A		sdm	Subunit assembly	Elimination C-terminal aromatic residues and the interchain cystein,reduces tetrameric structure	Altamirano_1999_Chem.Biol.Interact_119-120_53

Send your questions or comments to :Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.

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