Torpedo_number Report for: 563

human-BCHE

Mutation	Type	Evaluation system	Effect	Reference
D70G/ F561Y	sdm	Succinylcholine hydrolysis	mutation at 561 restores binding of inhibitors on 70 mutant	Neville_1992_EMBO.J_11_1641
D70G/ Y114H/ F561Y	sdm	Succinylcholine hydrolysis	mutations at 561 and 114 restore binding of inhibitors on 70 mutant	Neville_1992_EMBO.J_11_1641
D70G/ Y114H/ F561Y	sdm	Dibucaine inhibition	mutations at 561 and 114 restore binding of inhibitors on 70 mutant	Neville_1992_EMBO.J_11_1641
D70G/ Y114H/ F561Y	sdm	Natural mutation	Succinylcholine hydrolysis Dibucaine inhibition	Neville_1992_EMBO.J_11_1641
F561Y	sdm	Somatic mutation in tumors	co appears with D70G natural mutation partially restores the activity	Gnatt_1990_Cancer.Res_50_1983, Neville_1992_EMBO.J_11_1641, Soreq_1992_Trends.Biochem.Sci_17_353
W543A/ F547A/ W550A/ Y553A/ W557A/ F561A/ Y564A	sdm	Subunit assembly	Elimination C-terminal aromatic residues, reduces tetrameric structure	Altamirano_1999_Chem.Biol.Interact_119-120_53
W543A/ F547A/ W550A/ Y553A/ W557A/ F561A/ Y564A/ C571A	sdm	Subunit assembly	Elimination C-terminal aromatic residues and the interchain cystein,reduces tetrameric structure	Altamirano_1999_Chem.Biol.Interact_119-120_53

Send your questions or comments to :Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.

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