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Torpedo_number Report for: 331

9acar-k9m8p0
MutationKin.TypeEvaluation systemEffectReference
F331W natOP-resistanceInsecticide resistanceCarvalho_2012_Pestic.Biochem.Physiol_104_143

aphgo-ACHE1
MutationKin.TypeEvaluation systemEffectReference
S431F natOP-resistanceOP and carbamate resistanceAndrews_2004_Insect.Mol.Biol_13_555
S431F natOP-resistanceOP and carbamate resistanceToda_2004_Insect.Mol.Biol_13_549
A302S/
S431F		 natOP-resistanceOP and carbamate resistanceAndrews_2004_Insect.Mol.Biol_13_555
A302S/
S431F		 natOP-resistanceOP and carbamate resistanceToda_2004_Insect.Mol.Biol_13_549

bemta-ACHE1
MutationKin.TypeEvaluation systemEffectReference
F392W natOP-resistanceOP-resistanceAlon_2008_Insect.Biochem.Mol.Biol_38_940

brafl-ACHE1
MutationKin.TypeEvaluation systemEffectReference
W353F sdmOP-resistanceThe mutation virtually abolishes the difference in sensitivity to the inhibitorsPatel_2006_Cell.Biochem.Biophys_46_253

cimle-ACHE1
MutationKin.TypeEvaluation systemEffectReference
F331Y natOP-resistanceInsecticide resistanceKomagata_2021_Insect.Biochem.Mol.Biol__103637

cultr-ACHE1
MutationKin.TypeEvaluation systemEffectReference
F455W natOP-resistance resistant strain TYM 870-fold decrease in fenitroxon-sensitivityNabeshima_2004_Biochem.Biophys.Res.Commun_313_794
F455W natOP-resistanceF331W substitution in resistant C. tritaeniorhynchus in chinaAlout_2007_J.Med.Entomol_44_463
F455W natOP-resistanceF331W substitution in all strains C. tritaeniorhynchus in chinaWu_2016_J.Am.Mosq.Control.Assoc_32_144

drome-ACHE
MutationKin.TypeEvaluation systemEffectReference
F409A sdmInsecticide sensitivityBoublik_2002_Protein.Eng_15_43
F409G sdmBinding of Triton X-100 studiesdecrease the effect of Triton X-100 on maloxon phosphorylation Marcel_2000_J.Biol.Chem_275_11603

human-ACHE : (kinetic parameters)
MutationKin.TypeEvaluation systemEffectReference
E202Q/
F338A		 sdmOxime interactionCochran_2011_J.Biol.Chem_286_29718
D134H/
F338A		 sdmOxime interactionCochran_2011_J.Biol.Chem_286_29718
F295L/
Y337A/
F338A		 sdmOxime interactionCochran_2011_J.Biol.Chem_286_29718
F295S/
F338A		 sdmAcyl specificityAcyl pocket 800-fold decreased catalytic activity, orientation of His 447Shafferman_2005_Chem.Biol.Interact_157-158_123
F295T/
F338A		 sdmAcyl specificityAcyl pocket 3400-fold decreased catalytic activity, orientation of His 447Shafferman_2005_Chem.Biol.Interact_157-158_123
F295N/
F338A		 sdmAcyl specificityAcyl pocket 110-fold decreased catalytic activity, orientation of His 447Shafferman_2005_Chem.Biol.Interact_157-158_123
F295M/
F338A		 sdmAcyl specificity Acyl pocket Only 6-fold decreased catalytic activity, orientation of His 447Shafferman_2005_Chem.Biol.Interact_157-158_123
F295V/
F338A		 sdmAcyl specificityAcyl pocket 380-fold decreased catalytic activity, orientation of His 447Shafferman_2005_Chem.Biol.Interact_157-158_123
F295I/
F338A		 sdmAcyl specificityAcyl pocket 1130-fold decreased catalytic activity, orientation of His 447Shafferman_2005_Chem.Biol.Interact_157-158_123
F295L/
F338A		 sdmAcyl specificityAcyl pocket 55-fold decreased catalytic activity, orientation of His 447Shafferman_2005_Chem.Biol.Interact_157-158_123
F295L/
F338A		 sdmOxime interactionCochran_2011_J.Biol.Chem_286_29718
Y337A/
F338A		 sdmAcyl specificityShafferman_2005_Chem.Biol.Interact_157-158_123
Y337A/
F338A		 sdmOxime interactionnon-aging catalytic bioscavengerCochran_2011_J.Biol.Chem_286_29718
F295A/
F338A		 sdmAcyl specificityAcyl pocket 680-fold decreased catalytic activity, orientation of His 447Barak_2002_Biochemistry_41_8245,
Shafferman_2005_Chem.Biol.Interact_157-158_123,
Barak_2005_Chem.Biol.Interact_157-158_219
F295A/
F338A/
V407F		 sdmAcyl specificityAcyl pocket only 3-fold decreased catalytic activity compensate F295A/F338ABarak_2002_Biochemistry_41_8245,
Barak_2005_Chem.Biol.Interact_157-158_219
F338AkinsdmSignal transduction reduced kcat, marginal effect on inhibition by edrophoniumShafferman_1992_EMBO.J_11_3561,
Shafferman_1992_4th.ChE.Meeting.Eilat__165,
Ordentlich_1993_J.Biol.Chem_268_17083,
Shafferman_1993_Proc.Med.Def.Biosci.Rev_3_1097,
Barak_1994_J.Biol.Chem_269_6296,
Shafferman_1995_5th.ChE.Meeting.Madras__189,
Shafferman_1996_Biochem.J_318_833
F338AkinsdmAcyl specificityAcyl pocket decreased catalytic activity, orientation of His 447Barak_2002_Biochemistry_41_8245,
Shafferman_2005_Chem.Biol.Interact_157-158_123
F338AkinsdmOxime interactionCochran_2011_J.Biol.Chem_286_29718

human-BCHE : (kinetic parameters)
MutationKin.TypeEvaluation systemEffectReference
A199S/
F227A/
S287G/
A328W/
Y332G/
F329V		 sdmCocaine hydrolysis E11 Zheng_2010_Biochemistry_49_9113
A328G/
F329S		 sdmAgingA328G/F329S increases half-life of aging by DFP 4.2 timesMasson_1997_Biochem.J_327_601
E197Q/
F329S		 sdmAgingE197Q/F329S increases half-life of aging by DFP 54 timesMasson_1997_Biochem.J_327_601
F329LkinsdmOP-resistanceresistant to echothiophate Gnatt_1994_J.Neurochem_62_749
F329QkinsdmOP-resistanceresistant to echothiophate decreases IC50 of smaller than (iso-OMPA) OP DFPGnatt_1994_J.Neurochem_62_749
F329DkinsdmOP-resistanceresistant to echothiophate Gnatt_1994_J.Neurochem_62_749
F329CkinsdmOP-resistanceresistant to echothiophate Gnatt_1994_J.Neurochem_62_749
F329CkinsdmAgingF329C increases half-life of aging by DFP 2 timesMasson_1997_Biochem.J_327_601
F329A sdmAgingF329A increases half-life of aging by DFP 2 timesMasson_1997_Biochem.J_327_601
F329A sdmCationic triarylmethane dyesBiberoglu_2011_Arch.Biochem.Biophys_511_64
F329S sdmAgingF329S increases half-life of aging by DFP 2.5 timesMasson_1997_Biochem.J_327_601

lepsm-ACHE1A
MutationKin.TypeEvaluation systemEffectReference
F362Y natOP-resistanceazamethiphos resistanceKaur_2015_PLos.One_10_e0124220

mouse-ACHE : (kinetic parameters)
MutationKin.TypeEvaluation systemEffectReference
Y337A/
F338A		 sdmOxime interactionnon-aging catalytic bioscavengerKovarik_2004_Biochemistry_43_3222
F338GkinsdmSubstrate inhibitionlow substrate inhibition high increase of KssRadic_1993_Biochemistry_32_12074,
Radic_1994_J.Biol.Chem_269_11233

myzpe-ACHEm
MutationKin.TypeEvaluation systemEffectReference
S431F natOP-resistancepirimicarb resistanceNabeshima_2003_Biochem.Biophys.Res.Commun_307_15

nillu-ACHE1
MutationKin.TypeEvaluation systemEffectReference
F331H/
I332L		 natOP-resistance associated in carbofuran resistant strain (CAS)Kwon_2012_Pestic.Biochem.Physiol_103_94
F331C/
I332L		 natOP-resistance associated in chlorpyrifos resistant strain,
Zhang_2017_Insect.Mol.Biol_26_453
F331C natOP-resistance associated in chlorpyrifos resistant strain,
Zhang_2017_Insect.Mol.Biol_26_453

spolt-ACHE1
MutationKin.TypeEvaluation systemEffectReference

tetur-ACHE
MutationKin.TypeEvaluation systemEffectReference
G119S/
A280T/
F331W		 natOP-resistanceInsecticide resistance, amplified alleleKwon_2012_Insect.Biochem.Mol.Biol_42_212
G119S/
F331W		 natOP-resistanceInsecticide resistance, amplified alleleKwon_2012_Insect.Biochem.Mol.Biol_42_212
A280T/
F331W		 natOP-resistanceInsecticide resistance, amplified alleleKwon_2012_Insect.Biochem.Mol.Biol_42_212
F331C natOP-resistanceInsecticide resistanceAnazawa_2003_Insect.Biochem.Mol.Biol_33_509
F331W natOP-resistanceInsecticide resistanceKhajehali_2010_Pest.Manag.Sci_66_220
F331W natOP-resistanceInsecticide resistanceKwon_2010_Pestic.Biochem.Physiol_96_36
F331W natOP-resistanceInsecticide resistance, amplified alleleKwon_2010_Insect.Mol.Biol_19_195
F331W natOP-resistanceInsecticide resistance, amplified alleleKwon_2012_Insect.Biochem.Mol.Biol_42_212
F331W natOP-resistanceInsecticide resistanceAiki_2005_Pestic.Biochem.Physiol_82_154
F331Y natOP-resistanceInsecticide resistanceKhajehali_2010_Pest.Manag.Sci_66_220
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