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Torpedo_number Report for: 201
9neop-ACHE1
Mutation
Kin.
Type
Evaluation system
Effect
Reference
A314S
nat
OP-resistance
Triazophos carbofuran resistance
Jiang_2009_Biochem.Biophys.Res.Commun_378_269
aphgo-ACHE1
Mutation
Kin.
Type
Evaluation system
Effect
Reference
A302S
nat
OP-resistance
F139L_aphgo-ACHE2 and A302S_aphgo-ACHE1 found together in resistant strains
Li_2004_Insect.Biochem.Mol.Biol_34_397
A302S
nat
OP-resistance
F139L_aphgo-ACHE2 and A302S_aphgo-ACHE1 found together in resistant strains
Andrews_2004_Insect.Mol.Biol_13_555
A302S
nat
OP-resistance
F139L_aphgo-ACHE2 and A302S_aphgo-ACHE1 found together in resistant strains
Toda_2004_Insect.Mol.Biol_13_549
A302S/
S431F
nat
OP-resistance
OP and carbamate resistance
Andrews_2004_Insect.Mol.Biol_13_555
A302S/
S431F
nat
OP-resistance
OP and carbamate resistance
Toda_2004_Insect.Mol.Biol_13_549
apime-ACHE
Mutation
Kin.
Type
Evaluation system
Effect
Reference
A236S
site directed mutagenesis
OP-resistance
insensitivity to OP
Kozaki_2009_Pestic.Biochem.Physiol_95_6
apolu-ACHE1
Mutation
Kin.
Type
Evaluation system
Effect
Reference
A216S
nat
OP-resistance
Chlorpyrifos Trichlorfon Malathion Carbosulfan resistance
Wu_2015_Insect.Biochem.Mol.Biol_65_75
bacsu-pnbae
Mutation
Kin.
Type
Evaluation system
Effect
Reference
A107H/
A190C
sdm
Search for phosphotriesterase activity
50-fold increase in paraoxonase activity
Legler_2014_Front.Chem_2_46
bommo-ACHE1
Mutation
Kin.
Type
Evaluation system
Effect
Reference
A303S/
G329A/
L554S
sdm
OP-resistance
Wang_2014_Mol.Biol.Rep_41_429
culpi-ACHE1
Mutation
Kin.
Type
Evaluation system
Effect
Reference
A328S
nat
OP-resistance
resistance to propoxur but not to dichlorvos
Zhao_2014_PLoS.One_9_e952607
human-BCHE
Mutation
Kin.
Type
Evaluation system
Effect
Reference
A199S/
F227A/
P285A/
S287G/
A328W/
Y332G
sdm
Cocaine hydrolysis
4400-fold improved catalytic efficiency against-cocaine E9
Zheng_2014_Nat.Commun_5_3457
A199S/
F227A/
S287G/
A328W/
Y332G
sdm
Cocaine hydrolysis
2000-fold improved catalytic efficiency against-cocaine E9
Zheng_2008_J.Am.Chem.Soc_130_12148
A199S/
F227A/
S287G/
A328W/
Y332G/
F364C/
M532C
sdm
Cocaine hydrolysis
improved catalytic efficiency against-cocaine and increased biological half-life with new cross-subunit SS bonds
Fang_2014_Chem.Biol.Interact_214C_18
A199S/
F227A/
S287G/
A328W/
Y332G/
V377C/
A516C
sdm
Cocaine hydrolysis
improved catalytic efficiency against-cocaine and increased biological half-life with new cross-subunit SS bonds
Fang_2014_Chem.Biol.Interact_214C_18
A199S/
F227A/
S287G/
A328W/
Y332G/
N535C
sdm
Cocaine hydrolysis
improved catalytic efficiency against-cocaine and increased biological half-life with new cross-subunit SS bonds
Fang_2014_Chem.Biol.Interact_214C_18
A199S/
F227A/
S287G/
A328W/
Y332G/
F329V
sdm
Cocaine hydrolysis
E11
Zheng_2010_Biochemistry_49_9113
A199S/
F227L/
S287G/
A328W/
Y332G
sdm
Cocaine hydrolysis
1000-fold improved catalytic efficiency against-cocaine E
Zheng_2010_Biochemistry_49_9113
A199S/
F227A/
S287G/
A328W/
E441D
sdm
Cocaine hydrolysis
improved catalytic efficiency against-cocaine E
Xue_2011_Mol.Pharmacol_79_290
A199S/
F227I/
S287G/
A328W/
Y332G
sdm
Cocaine hydrolysis
1000-fold improved catalytic efficiency against-cocaine E
Zheng_2010_Biochemistry_49_9113
A199S/
F227V/
S287G/
A328W/
Y332G
sdm
Cocaine hydrolysis
1000-fold improved catalytic efficiency against-cocaine E
Zheng_2010_Biochemistry_49_9113
A199S/
S287G/
A328W/
Y332G
sdm
Cocaine hydrolysis
CocH1 456-fold improved catalytic efficiency against (-)-cocaine
Pan_2005_Proc.Natl.Acad.Sci.U.S.A_102_16656
A199S/
S287G/
A328W/
Y332G
sdm
Cocaine hydrolysis
Selectively blocks cocaine toxicity and reinstatement of drug seeking in rats (mutant fused to albumin TV-1380)
Brimijoin_2008_Neuropsychopharmacology_33_2715
A199S/
S287G/
A328W/
Y332G
sdm
Cocaine hydrolysis
Yang_2010_Chem.Biol.Interact_187_148
A199S/
S287G/
A328W/
Y332G/
L286I
sdm
Cocaine hydrolysis
E10
Zheng_2010_Biochemistry_49_9113
A199V
nat
Silent variant
Natural mutation Low activity
Sakamoto_1998_Clin.Chim.Acta_274_159
mouse-BCHE
Mutation
Kin.
Type
Evaluation system
Effect
Reference
A199S/
F227A/
S287G/
A328W/
Y332G
sdm
Cocaine hydrolysis
Chen_2015_Biochem.J_466_243
musdo-ACHE
Mutation
Kin.
Type
Evaluation system
Effect
Reference
A236S
nat
OP-resistance
insensitivity to OP
Kozaki_2009_Pestic.Biochem.Physiol_95_6
pluxy-ACHE1
Mutation
Kin.
Type
Evaluation system
Effect
Reference
A201S
nat
OP-resistance
G227A A201S A441G (G324A,A298S,A324G) found together in resistant strains but G227A likely to be important
Baek_2005_Pestic.Biochem.Physiol_81_164
A201S
nat
OP-resistance
D131G A201S A441G (D229G,,A298S,A324G) found together in resistant strains but G227A likely to be important
Lee_2007_Biochem.Biophys.Res.Commun_353_591
A201S
nat
OP-resistance
G227A A201S (G324A,A298S) found together in resistant strains but A201S likely to be important
Kim_2012_J.Asia.Pac.Entomol_15_401
A201S
nat
OP-resistance
A298S and G324A mutations showed no correlation with levels of resistance to acephate
Sonoda_2014_Insect.Biochem.Mol.Biol_48_83
spolt-ACHE1
Mutation
Kin.
Type
Evaluation system
Effect
Reference
tetur-ACHE
Mutation
Kin.
Type
Evaluation system
Effect
Reference
A201S
nat
OP-resistance
Insecticide resistance
Khajehali_2010_Pest.Manag.Sci_66_220
tutab-ACHE1
Mutation
Kin.
Type
Evaluation system
Effect
Reference
A201S
nat
OP-resistance
A201S present in resistant strain
Haddi_2017_J.Appl.Entomol_141_612
Send your questions or comments to :
Mail to:
Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite:
Lenfant 2013 Nucleic.Acids.Res.
or
Marchot Chatonnet 2012 Prot.Pept Lett.
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