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Torpedo_number Report for: 427
human-ACHE
Mutation
Kin.
Type
Evaluation system
Effect
Reference
A434S
sdm
PROSS algorithm
Expression in E Coli
Goldenzweig_2016_Mol.Cell_63_337
human-BCHE
Mutation
Kin.
Type
Evaluation system
Effect
Reference
D70G/
S425P
sdm
Succinylcholine hydrolysis/Dibucaine inhibition
S425P exaggerates D70G effects of dibucaine and succinylcholine resistance
Gnatt_1990_Cancer.Res_50_1983
,
Neville_1990_J.Neurosci.Res_27_452
,
Neville_1992_EMBO.J_11_1641
,
Gnatt_1990_Cancer.Res_50_1983
,
Schwarz_1995_Pharmacol.Th_67_283
D70G/
Y114H/
S425P
sdm
Succinylcholine hydrolysis Dibucaine inhibition
mutations at 561 and 114 restore binding of inhibitors on 70 mutant
Neville_1992_EMBO.J_11_1641
,
Schwarz_1995_Pharmacol.Ther_67_283
S425P
sdm
Dibucaine inhibition, Succinylcholine hydrolysis
test of cooperativity with D70G limited reduction activity
Neville_1992_EMBO.J_11_1641
Send your questions or comments to :
Mail to:
Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite:
Lenfant 2013 Nucleic.Acids.Res.
or
Marchot Chatonnet 2012 Prot.Pept Lett.
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and
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