ESTHER
Database
Home
Search
Text search
aql query
In Class
Query Builder
Preformed queries
Species
Structures
Mutations
Interactants
Diseases
Genes
Insecticides
Other
Full List
Queries for insecticide resistance
AQL exemples
Tools
Blast
HMMER
Clustal
Psiblast
Intra
Families
Overall Table
Tree Table &
Old Table
Tree Table
Old Table
Explore genes with AQL
Explore species with AQL
All figures of families
Biological
data
Structures
Table
Explore structure with AQL
Mutations
Mutation Viewer
Mutalign
Mutalign 2
Mutalign for insecticide resistance
Queries for insecticide resistance
Explore mutation with AQL
Interactants
Substrates
Inhibitors
Reactivators
Kinetic comparison tool
Inhibitor types
Substrate types
Reactivator types
Explore interactants with AQL
Diseases
Table
Explore disease with AQL
Basics on AChE
Kinetics notes
Gene structures
Molecular forms
AChE Family
Human AChE
ESTHER definition
What is up?
Likid
DB Explorer
Meetings
Suplementary Data
Latest modifications
Bibliography (all years)
Acknowledgments
& disclaimer
Torpedo_number
Kinetic parameters
Tree Display
AceDB Schema
XML Display
Feedback
Torpedo_number Report for: 400
boomi-ACHE3
Mutation
Kin.
Type
Evaluation system
Effect
Reference
I492M
nat
Expression
Low activity or expression
Temeyer_2007_J.Med.Entomol_44_1013
brafl-ACHE2
Mutation
Kin.
Type
Evaluation system
Effect
Reference
F422L
sdm
Acyl specificity
hydrolyze BsCh and AsCh equally
Pezzementi_2003_Comp.Biochem.Physiol.B.Biochem.Mol.Biol_136_813
F422V
sdm
Acyl specificity
hydrolyze BsCh and AsCh equally
Pezzementi_2003_Comp.Biochem.Physiol.B.Biochem.Mol.Biol_136_813
human-ACHE
Mutation
Kin.
Type
Evaluation system
Effect
Reference
F295A/
F338A/
V407F
sdm
Acyl specificity
Acyl pocket only 3-fold decreased catalytic activity compensate F295A/F338A
Barak_2002_Biochemistry_41_8245
,
Barak_2005_Chem.Biol.Interact_157-158_219
Y72N/
Y124Q/
W286A/
F295L/
F297V/
Y337A/
V407F
sdm
Acyl specificity
Acyl pocket V407F does not increase kcat of the hexamutant
Barak_2002_Biochemistry_41_8245
Send your questions or comments to :
Mail to:
Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite:
Lenfant 2013 Nucleic.Acids.Res.
or
Marchot Chatonnet 2012 Prot.Pept Lett.
For technical information about these pages see:
ESTHER Home Page
and
ACEDB Home Page
AcePerl Lincoln Stein Home Page
webmaster
Acknowledgements and disclaimer
