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Torpedo_number Report for: 388
human-BCHE
Mutation
Kin.
Type
Evaluation system
Effect
Reference
R386C
nat
Succinylcholine hydrolysis
Natural mutation Succinylcholine hydrolysis C to T substitution
Yen_2003_Clin.Chem_49_1297
R386C
nat
Succinylcholine hydrolysis
Natural mutation Succinylcholine hydrolysis C to T substitution
On-Kei Chan_2005_Clin.Chim.Acta_351_155
R386C
nat
Natural mutation
no activity
Brazzolotto_2021_Pharmacogenomics.J_21_165
mouse-3neur
Mutation
Kin.
Type
Evaluation system
Effect
Reference
R451C
sdm
Site directed mutagenesis
R451C substitution in neuroligin-3 R451C mutant mice showed impaired social interactions but enhanced spatial learning abilities
Tabuchi_2007_Science_318_71
mouse-ACHE
Mutation
Kin.
Type
Evaluation system
Effect
Reference
R395C
site directed mutagenesis
Intracellular retention
Intracellular retention similar to R451C_human-NLGN3
De Jaco_2005_Chem.Biol.Interact_157-158_371
R395C
site directed mutagenesis
Intracellular retention
Intracellular retention similar to R451C_human-NLGN3
De Jaco_2006_J.Biol.Chem_281_9667
mouse-BCHE
Mutation
Kin.
Type
Evaluation system
Effect
Reference
R386C
site directed mutagenesis
Intracellular retention
Intracellular retention similar to R451C_human-NLGN3
De Jaco_2005_Chem.Biol.Interact_157-158_371
R386C
site directed mutagenesis
Intracellular retention
Intracellular retention similar to R451C_human-NLGN3
De Jaco_2006_J.Biol.Chem_281_9667
ratno-1neur
Mutation
Kin.
Type
Evaluation system
Effect
Reference
R473C
site directed mutagenesis
Intracellular retention
Defect in protein processing
Comoletti_2004_J.Neurosci_24_4889
R473T
site directed mutagenesis
No effect
No effect
Comoletti_2004_J.Neurosci_24_4889
C286A/
R473C
site directed mutagenesis
Intracellular retention
Defect in protein processing
Comoletti_2004_J.Neurosci_24_4889
ratno-3neur
Mutation
Kin.
Type
Evaluation system
Effect
Reference
R471C
site directed mutagenesis
Intracellular retention
Defect in protein processing
Comoletti_2004_J.Neurosci_24_4889
Send your questions or comments to :
Mail to:
Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite:
Lenfant 2013 Nucleic.Acids.Res.
or
Marchot Chatonnet 2012 Prot.Pept Lett.
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