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Torpedo_number Report for: 342
human-ACHE
:
(
kinetic parameters
)
Mutation
Kin.
Type
Evaluation system
Effect
Reference
E84Q/
D349N/
E358Q
kin
sdm
Electrostatic
Electrostatic attraction hypothesis no significant effect
Shafferman_1994_EMBO.J_13_3448
E84Q/
E292A/
D349N/
E358Q
kin
sdm
Electrostatic
Electrostatic attraction hypothesis no significant effect
Shafferman_1994_EMBO.J_13_3448
E84Q/
E285A/
E292A/
D349N/
E358Q
kin
sdm
Electrostatic
Electrostatic attraction hypothesis no significant effect
Shafferman_1994_EMBO.J_13_3448
E84Q/
D349N/
E358Q/
E389Q/
D390N
kin
sdm
Electrostatic
Electrostatic attraction hypothesis no significant effect
Shafferman_1994_EMBO.J_13_3448
E84Q/
E292A/
D349N/
E358Q/
E389Q/
D390N
kin
sdm
Electrostatic
Electrostatic attraction hypothesis no significant effect
Shafferman_1994_EMBO.J_13_3448
E84Q/
E292A/
D349N/
E358Q/
E389Q/
D390N
kin
sdm
Heat and pressure stability
strengthened heat stability decreased pressure stability
Clery-Barraud_2002_Eur.J.Biochem_269_4297
E84Q/
E285A/
E292A/
D349N/
E358Q/
E389Q/
D390N
kin
sdm
Electrostatic
Electrostatic attraction hypothesisno significant effect
Shafferman_1994_EMBO.J_13_3448
E292A/
D349N/
E358Q
kin
sdm
Electrostatic
Electrostatic attraction hypothesis no significant effect
Shafferman_1994_EMBO.J_13_3448
E292A/
D349N/
E358Q/
E389Q/
D390N
kin
sdm
Electrostatic
Electrostatic attraction hypothesis no significant effect
Shafferman_1994_EMBO.J_13_3448
D349N
kin
sdm
Electrostatic
Electrostatic attraction hypothesisminor effect on catalysis
Shafferman_1994_EMBO.J_13_3448
D349N/
E358Q
kin
sdm
Electrostatic
Electrostatic attraction hypothesis, minor effect on catalysis
Shafferman_1994_EMBO.J_13_3448
D349N/
E358Q/
E389Q/
D390N
kin
sdm
Electrostatic
Electrostatic attraction hypothesis minor effect on catalysis
Shafferman_1994_EMBO.J_13_3448
human-BCHE
Mutation
Kin.
Type
Evaluation system
Effect
Reference
D340H
sdm
OP-resistance
increased resistance to nerve agent retained robust intrinsic catalytic efficiency
Dwyer_2014_Biochemistry_53_4476
Y332S/
D340H
sdm
OP-resistance
increased resistance to nerve agent retained robust intrinsic catalytic efficiency
Dwyer_2014_Biochemistry_53_4476
Send your questions or comments to :
Mail to:
Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite:
Lenfant 2013 Nucleic.Acids.Res.
or
Marchot Chatonnet 2012 Prot.Pept Lett.
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