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Torpedo_number Report for: 233

anica-cxest
MutationKin.TypeEvaluation systemEffectReference
W220G natOP-resistance Resistant to malathionZhu_1999_Insect.Biochem.Mol.Biol_29_417

colho-E3aest7
MutationKin.TypeEvaluation systemEffectReference
W251S natOP-resistanceCarvalho_2006_Vet.Parasitol_140_344
W251S natOP-resistanceCarvalho_2009_Med.Vet.Entomol_23_86
W251S natPyrethroids hydrolysisda Silva_2009_Genet.Mol.Res_8_1067
W251L natOP-resistanceBergamo_2015_PLos.One_10_e0128441

drome-ACHE
MutationKin.TypeEvaluation systemEffectReference
W309G sdmBinding of Triton X-100 studiesno effect on Triton X-100 bindingMarcel_2000_J.Biol.Chem_275_11603

drome-EST23aes07
MutationKin.TypeEvaluation systemEffectReference
W251L sdmPyrethroids hydrolysissearch for Pyrethroids hydrolysis activities Heidari_2005_Insect.Biochem.Mol.Biol_35_597

human-BCHE
MutationKin.TypeEvaluation systemEffectReference
W231A sdmSuccinylthiocholine bindingProbable disorganization of the active siteMasson_1997_Biochemistry_36_2266
W231S natSuccinylcholine hydrolysisNatural mutation Succinylcholine hydrolysisDell-Kuster_2015_Eur.J.Anaesthesiol_32_687

luccu-E3aest7
MutationKin.TypeEvaluation systemEffectReference
W251S sdmOP-resistancesearch for OP hydrolase and MCE activities Heidari_2004_Insect.Biochem.Mol.Biol_34_353
W251S sdmPyrethroids hydrolysissearch for Pyrethroids hydrolysis activities Heidari_2005_Insect.Biochem.Mol.Biol_35_597
W251S sdmPyrethroids hydrolysisHydrolysis of individual isomers of fluorogenic pyrethroid analogs by mutant carboxylesterasesDevonshire_2007_Insect.Biochem.Mol.Biol_37_891
W251T sdmOP-resistancesearch for OP hydrolase and MCE activities Heidari_2004_Insect.Biochem.Mol.Biol_34_353
W251T sdmPyrethroids hydrolysissearch for Pyrethroids hydrolysis activities Heidari_2005_Insect.Biochem.Mol.Biol_35_597
W251T sdmPyrethroids hydrolysisHydrolysis of individual isomers of fluorogenic pyrethroid analogs by mutant carboxylesterasesDevonshire_2007_Insect.Biochem.Mol.Biol_37_891
W251G sdmOP-resistancesearch for OP hydrolase and MCE activities Heidari_2004_Insect.Biochem.Mol.Biol_34_353
W251G sdmPyrethroids hydrolysissearch for Pyrethroids hydrolysis activities Heidari_2005_Insect.Biochem.Mol.Biol_35_597
W251G sdmPyrethroids hydrolysisHydrolysis of individual isomers of fluorogenic pyrethroid analogs by mutant carboxylesterasesDevonshire_2007_Insect.Biochem.Mol.Biol_37_891
W251A sdmOP-resistancesearch for OP hydrolase and MCE activities Heidari_2004_Insect.Biochem.Mol.Biol_34_353
W251A sdmPyrethroids hydrolysissearch for Pyrethroids hydrolysis activities Heidari_2005_Insect.Biochem.Mol.Biol_35_597
W251A sdmPyrethroids hydrolysisHydrolysis of individual isomers of fluorogenic pyrethroid analogs by mutant carboxylesterasesDevonshire_2007_Insect.Biochem.Mol.Biol_37_891
P250S/
W251L		 sdmOP-resistancesearch for OP hydrolase and MCE activities Heidari_2004_Insect.Biochem.Mol.Biol_34_353
P250S/
W251L		 sdmPyrethroids hydrolysissearch for Pyrethroids hydrolysis activities Heidari_2005_Insect.Biochem.Mol.Biol_35_597
P250S/
W251L		 sdmPyrethroids hydrolysisHydrolysis of individual isomers of fluorogenic pyrethroid analogs by mutant carboxylesterasesDevonshire_2007_Insect.Biochem.Mol.Biol_37_891
G137D/
W251L		 sdmOP-resistancesearch for OP hydrolase and MCE activities Heidari_2004_Insect.Biochem.Mol.Biol_34_353
G137D/
W251L		 sdmPyrethroids hydrolysissearch for Pyrethroids hydrolysis activities Heidari_2005_Insect.Biochem.Mol.Biol_35_597
G137D/
W251L		 sdmPyrethroids hydrolysisHydrolysis of individual isomers of fluorogenic pyrethroid analogs by mutant carboxylesterasesDevonshire_2007_Insect.Biochem.Mol.Biol_37_891
W251L/
F309L		 sdmOP-resistancesearch for OP hydrolase and MCE activities Heidari_2004_Insect.Biochem.Mol.Biol_34_353
W251L/
F309L		 sdmPyrethroids hydrolysissearch for Pyrethroids hydrolysis activities Heidari_2005_Insect.Biochem.Mol.Biol_35_597
W251L/
F309L		 sdmPyrethroids hydrolysisHydrolysis of individual isomers of fluorogenic pyrethroid analogs by mutant carboxylesterasesDevonshire_2007_Insect.Biochem.Mol.Biol_37_891
W251L nat, sdmOP-resistance mutant bowfly are resistant to OP insecticides, increases OP hydrolase activity (E3-Rmal Malathion and dimethyl OP) and alters kinetics for several carboxylester substratesDevonshire_2003_Pestic.Biochem.Physiol_76_1
W251L nat, sdmOP-resistance2 G137D and 2 W251L haplotypes found in natural populationsNewcomb_2005_J.Mol.Evol_60_207
W251L nat, sdmOP-resistancesearch for OP hydrolase and MCE activities Heidari_2004_Insect.Biochem.Mol.Biol_34_353
W251L nat, sdmPyrethroids hydrolysissearch for Pyrethroids hydrolysis activities Heidari_2005_Insect.Biochem.Mol.Biol_35_597
W251L nat, sdmPyrethroids hydrolysisHydrolysis of individual isomers of fluorogenic pyrethroid analogs by mutant carboxylesterasesDevonshire_2007_Insect.Biochem.Mol.Biol_37_891
W251L nat, sdmOP-resistancesearch for OP hydrolase and MCE activities Campbell_1998_Insect.Biochem.Mol.Biol_28_139

musdo-EST23aes07
MutationKin.TypeEvaluation systemEffectReference
W251L natOP-resistanceZhang_2020_Ecotoxicology_29_35
W251S natOP-resistanceincreases OP hydrolase activity (E3-Rmal Malathion and dimethyl OP) Taskin_2004_Genetika_40_478
W251C natOP-resistanceThailand strain (E3-Rmal Malathion and dimethyl OP) Taskin_2004_Genetika_40_478
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