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Torpedo_number
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Torpedo_number Report for: 229
human-BCHE
Mutation
Kin.
Type
Evaluation system
Effect
Reference
F227A
sdm
PROSS algorithm
Expression in E Coli
Brazzolotto_2017_Molecules_22_
A199S/
F227A/
P285A/
S287G/
A328W/
Y332G
sdm
Cocaine hydrolysis
4400-fold improved catalytic efficiency against-cocaine E9
Zheng_2014_Nat.Commun_5_3457
A199S/
F227A/
S287G/
A328W/
Y332G
sdm
Cocaine hydrolysis
2000-fold improved catalytic efficiency against-cocaine E9
Zheng_2008_J.Am.Chem.Soc_130_12148
A199S/
F227A/
S287G/
A328W/
Y332G/
F364C/
M532C
sdm
Cocaine hydrolysis
improved catalytic efficiency against-cocaine and increased biological half-life with new cross-subunit SS bonds
Fang_2014_Chem.Biol.Interact_214C_18
A199S/
F227A/
S287G/
A328W/
Y332G/
V377C/
A516C
sdm
Cocaine hydrolysis
improved catalytic efficiency against-cocaine and increased biological half-life with new cross-subunit SS bonds
Fang_2014_Chem.Biol.Interact_214C_18
A199S/
F227A/
S287G/
A328W/
Y332G/
N535C
sdm
Cocaine hydrolysis
improved catalytic efficiency against-cocaine and increased biological half-life with new cross-subunit SS bonds
Fang_2014_Chem.Biol.Interact_214C_18
A199S/
F227A/
S287G/
A328W/
Y332G/
F329V
sdm
Cocaine hydrolysis
E11
Zheng_2010_Biochemistry_49_9113
A199S/
F227L/
S287G/
A328W/
Y332G
sdm
Cocaine hydrolysis
1000-fold improved catalytic efficiency against-cocaine E
Zheng_2010_Biochemistry_49_9113
A199S/
F227A/
S287G/
A328W/
E441D
sdm
Cocaine hydrolysis
improved catalytic efficiency against-cocaine E
Xue_2011_Mol.Pharmacol_79_290
A199S/
F227I/
S287G/
A328W/
Y332G
sdm
Cocaine hydrolysis
1000-fold improved catalytic efficiency against-cocaine E
Zheng_2010_Biochemistry_49_9113
A199S/
F227V/
S287G/
A328W/
Y332G
sdm
Cocaine hydrolysis
1000-fold improved catalytic efficiency against-cocaine E
Zheng_2010_Biochemistry_49_9113
F227A/
S287G/
A328W/
Y332M
sdm
Cocaine hydrolysis
AME359 CocH, 34-fold improved catalytic efficiency against (-)-cocaine
Pancook_2003_FASEB.J_17_A565
mouse-BCHE
Mutation
Kin.
Type
Evaluation system
Effect
Reference
A199S/
F227A/
S287G/
A328W/
Y332G
sdm
Cocaine hydrolysis
Chen_2015_Biochem.J_466_243
Send your questions or comments to :
Mail to:
Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite:
Lenfant 2013 Nucleic.Acids.Res.
or
Marchot Chatonnet 2012 Prot.Pept Lett.
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