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Torpedo_number
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Torpedo_number Report for: 129
bacdo-ACHE
Mutation
Kin.
Type
Evaluation system
Effect
Reference
I214V/
G488S/
Q643R
nat
OP-resistance
OP-resistance (Fenitrothion)
Hsu_2006_Insect.Biochem.Mol.Biol_36_396
I214V
nat
OP-resistance
OP-resistance (Fenitrothion)
Hsu_2006_Insect.Biochem.Mol.Biol_36_396
bacol-ACHE
Mutation
Kin.
Type
Evaluation system
Effect
Reference
I214V
nat
OP-resistance
OP-resistance (omethoate)
Vontas_2002_Insect.Mol.Biol_11_329
I214V
nat
Natural mutation
Not found associated with resistance
Kakani_2008_Insect.Biochem.Mol.Biol_38_781
I214V/
G488S
nat
OP-resistance
OP-resistance (omethoate)
Vontas_2002_Insect.Mol.Biol_11_329
drome-ACHE
Mutation
Kin.
Type
Evaluation system
Effect
Reference
I199A
sdm
Insecticide sensitivity
Boublik_2002_Protein.Eng_15_43
I199W
sdm
Insecticide sensitivity
Boublik_2002_Protein.Eng_15_43
I199V
sdm
Insecticide sensitivity
Boublik_2002_Protein.Eng_15_43
I199V
sdm
Insecticide sensitivity
Menozzi_2004_BMC.Evol.Biol_4_4
I199V
sdm
Insecticide sensitivity
Chen_2001_Insect.Biochem.Mol.Biol_31_805
I199V
sdm
OP-resistance
OP-resistance lower than multiple mutations,mut found in Saltillo strain together with F115S G303A F368Y
Mutero_1994_Proc.Natl.Acad.Sci.U.S.A_91_5922
I199T
sdm
Insecticide sensitivity
Boublik_2002_Protein.Eng_15_43
I199R
sdm
Insecticide sensitivity
Boublik_2002_Protein.Eng_15_43
I199K
sdm
Insecticide sensitivity
Boublik_2002_Protein.Eng_15_43
I199G
sdm
Insecticide sensitivity
Boublik_2002_Protein.Eng_15_43
I199E
sdm
Insecticide sensitivity
Boublik_2002_Protein.Eng_15_43
F115S/
I199V
sdm
OP-resistance
OP-resistance lower than multiple,mut found in Saltillo strain together with I199V G303A F368Y
Mutero_1994_Proc.Natl.Acad.Sci.U.S.A_91_5922
F115S/
I199V/
G303A
sdm
OP-resistance
OP-resistance lower than multiple,mut found in Saltillo strain together with I199V G303A F368Y
Mutero_1994_Proc.Natl.Acad.Sci.U.S.A_91_5922
F115S/
I199V/
F368Y
sdm
OP-resistance
OP-resistance lower than multiple,mut found in Saltillo strain together with I199V G303A F368Y
Mutero_1994_Proc.Natl.Acad.Sci.U.S.A_91_5922
F115S/
I199V/
G303A/
F368Y
nat
Natural mutation
Saltillo strain OP-resistance
Mutero_1994_Proc.Natl.Acad.Sci.U.S.A_91_5922
I199V/
G303A
sdm, nat
OP-resistance
Bygdia strain and sdm OP-resistance
Mutero_1994_Proc.Natl.Acad.Sci.U.S.A_91_5922
I199V/
G303A
sdm, nat
OP-resistance
Bygdia strain and sdm OP-resistance
Mutero_1994_Proc.Natl.Acad.Sci.U.S.A_91_592
I199T/
G303A
nat
OP-resistance
Pierrefeu strain OP-resistance
Mutero_1994_Proc.Natl.Acad.Sci.U.S.A_91_5922
I199T/
G303A
nat
OP-resistance
Pierrefeu strain OP-resistance
Mutero_1994_Proc.Natl.Acad.Sci.U.S.A_91_592
I199V/
F368Y
sdm
OP-resistance
Two mutations found in Saltillo strain
Mutero_1994_Proc.Natl.Acad.Sci.U.S.A_91_5922
I199V/
G303A/
F368Y
sdm
OP-resistance
Three mutations found in OP-resistant Saltillo strain
Mutero_1994_Proc.Natl.Acad.Sci.U.S.A_91_5922
human-ACHE
:
(
kinetic parameters
)
Mutation
Kin.
Type
Evaluation system
Effect
Reference
V132A
kin
sdm
Back door hypothesis
V132A reduce steric hindrance at the rim of the hypothetical back door,No effect
Kronman_1994_J.Biol.Chem_269_27819
V132K
kin
sdm
Back door hypothesis
V132K introduce a charge and should block the door, 6X increase of Km for ATc but not for TB through interaction with W86
Kronman_1994_J.Biol.Chem_269_27819
human-BCHE
:
(
kinetic parameters
)
Mutation
Kin.
Type
Evaluation system
Effect
Reference
V127D
kin
sdm
Back door hypothesis
No changes in Km BTCh or Ki of inhibitors tested
Loewenstein-Lichtenstein_1996_Mol.Pharmacol_50_1423
luccu-ACHE
Mutation
Kin.
Type
Evaluation system
Effect
Reference
I199V
sdm
Insecticide sensitivity
Chen_2001_Insect.Biochem.Mol.Biol_31_805
I199T
sdm
Insecticide sensitivity
Chen_2001_Insect.Biochem.Mol.Biol_31_805
F115S/
I199V/
F368Y
sdm
OP-resistance
Chen_2001_Insect.Biochem.Mol.Biol_31_805
I199V/
F368Y
sdm
OP-resistance
Chen_2001_Insect.Biochem.Mol.Biol_31_805
I199V/
G303A/
F368Y
sdm
OP-resistance
Chen_2001_Insect.Biochem.Mol.Biol_31_805
musdo-ACHE
Mutation
Kin.
Type
Evaluation system
Effect
Reference
torma-ACHE
Mutation
Kin.
Type
Evaluation system
Effect
Reference
V129K
sdm
Back door hypothesis
No effect of mutation
Faerman_1996_FEBS.Lett_386_65
V129R
sdm
Back door hypothesis
No effect of mutation
Faerman_1996_FEBS.Lett_386_65
V129R/
C231S
sdm
Back door hypothesis
No effect of mutation
Faerman_1996_FEBS.Lett_386_65
V129K/
C231S
sdm
Back door hypothesis
No effect of mutation
Faerman_1996_FEBS.Lett_386_65
Send your questions or comments to :
Mail to:
Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite:
Lenfant 2013 Nucleic.Acids.Res.
or
Marchot Chatonnet 2012 Prot.Pept Lett.
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