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Torpedo_number Report for: 117
bacsu-pnbae
Mutation
Kin.
Type
Evaluation system
Effect
Reference
A107H
sdm
Search for phosphotriesterase activity
Legler_2014_Front.Chem_2_46
A107K
sdm
Search for phosphotriesterase activity
7-fold increase kcat/Km for benzoylthiocholine
Legler_2014_Front.Chem_2_46
A107H/
A190C
sdm
Search for phosphotriesterase activity
50-fold increase in paraoxonase activity
Legler_2014_Front.Chem_2_46
human-ACHE
Mutation
Kin.
Type
Evaluation system
Effect
Reference
G120A
sdm
Oxyanion hole
Alteration of oxyanion hole structure
Ordentlich_1998_J.Biol.Chem_273_19509
human-BCHE
:
(
kinetic parameters
)
Mutation
Kin.
Type
Evaluation system
Effect
Reference
G115H
sdm
Search for phosphotriesterase activity
No catalytic activity
Millard_1995_Biochemistry_34_15925
,
Lockridge_1997_Biochemistry_36_786
G115A
kin
sdm
Oxyanion hole
reduced kcat and kcat/Km
Loewenstein-Lichtenstein_1996_Mol.Pharmacol_50_1423
G115S
kin
sdm
Oxyanion hole
reduced kcat and kcat/Km
Loewenstein-Lichtenstein_1996_Mol.Pharmacol_50_1423
G115C
kin
sdm
Oxyanion hole
significant reduction of activity but reacts with DFP
Loewenstein-Lichtenstein_1996_Mol.Pharmacol_50_1423
G115D
kin
sdm, nat
Oxyanion hole
no activity
Loewenstein-Lichtenstein_1996_Mol.Pharmacol_50_1423
G115D
kin
sdm, nat
Silent variant
Natural mutation Silent, no activity
Primo-Parmo_1992_4th.ChE.Meeting.Eilat__61
,
Primo-Parmo_1996_Am.J.Hum.Genet_58_52
G115D
kin
sdm, nat
Silent variant
Natural mutation Increased instability
Primo-Parmo_1997_Pharmacogenet_7_27
G115E
kin
sdm
Oxyanion hole
significant reduction of activity
Loewenstein-Lichtenstein_1996_Mol.Pharmacol_50_1423
human-CES1
Mutation
Kin.
Type
Evaluation system
Effect
Reference
G143H
sdm
Search for phosphotriesterase activity
no detectable OP hydrolase activity
Legler_2014_Front.Chem_2_46
Send your questions or comments to :
Mail to:
Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite:
Lenfant 2013 Nucleic.Acids.Res.
or
Marchot Chatonnet 2012 Prot.Pept Lett.
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