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Substrate Report for: Succinylcholine~Suxamethonium

Skeletal muscle relaxant. Substrate and Inhibitor of BCHE. A quaternary skeletal muscle relaxant usually used in the form of its bromide, chloride, or iodide. It is a depolarizing relaxant, acting in about 30 seconds and with a duration of effect averaging three to five minutes. Succinylcholine is used in surgical, anesthetic, and other procedures in which a brief period of muscle relaxation is called for.


General
Type Trimethylammonium, Choline ester
Chemical_Nomenclature trimethyl-[2-[4-oxo-4-[2-(trimethylazaniumyl)ethoxy]butanoyl]oxyethyl]azanium
Canonical SMILES C[N+](C)(C)CCOC(=O)CCC(=O)OCC[N+](C)(C)C
InChI InChI=1S/C14H30N2O4/c1-15(2,3)9-11-19-13(17)7-8-14(18)20-12-10-16(4,5)6/h7-12H2,1-6H3/q+2
InChIKey AXOIZCJOOAYSMI-UHFFFAOYSA-N
Other name(s) Succinylcholine ; 2,2'-[(1,4-Dioxo-1,4-butanediyl)bis(oxy)]bis[N,N,N-trimethylethanaminium]di-bromide or -chloride or -iodide ; Suxamethonium ; Succinyldicholine ; Anectine ; Quelicin ; Succinocholine ; Ditilin ; Succinoylcholine ; Succinylbischoline ; Dicholine succinate Myorelaxin ; Brevedil M ; Choline, bromide, succinate (2:1) ; midarine ; pantolax ; scoline
________________________________________________________________________________________________
MW|290.399
Formula|C14H30N2O4
CAS_number|6101-15-1
PubChem|5314
UniChem|AXOIZCJOOAYSMI-UHFFFAOYSA-N
IUPHAR|4004
Wikipedia|Suxamethonium

Target
Families | Succinylcholine~Suxamethonium ligand of proteins in family: BCHE
Protein | human-BCHE

References:
Search PubMed for references concerning: Succinylcholine~Suxamethonium

68 more
    Title: Genetic variants of human serum cholinesterase influence metabolism of the muscle relaxant succinylcholine.
    Lockridge O
    Ref: Pharmacol Ther, 47:35, 1990 : PubMed

            

    Title: Differential inhibition of plasma cholinesterase variants using the dibutyrate analogue of pancuronium bromide
    Whittaker M, Britten JJ
    Ref: Hum Hered, 31:242, 1981 : PubMed

            

    Title: The activity of various esterase inhibitors towards atypical human serum cholinesterase
    Kalow W, Davies R0
    Ref: Biochemical Pharmacology, 1:183, 1958 : PubMed