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Substrate Report for: Skyllamycin-like-precursor

Skyllamycin: Cyclic depsipeptide produced by Streptomyces sp.; skyllamycin A inhibits the binding of PDGF to the extracellular domain of its receptor. 11mer macrolactone peptide with an N-terminal 2-[1-(Z)-propenyl]-cinnamoyl moiety attached; Skyxy-TE that catalyzes both epimerization and cyclization in skyllamycin biosynthesis


General
Type Peptide, Natural, Macrolide, Antibiotic
Chemical_Nomenclature
Canonical SMILES COC1=CC=C(C=C1)CC(NC(=O)C2CCCN2C(=O)C(NC(=O)CNC(=O)C(NC(=O)C(C)NC(=O)C(NC(=O)C=CC3=CC=CC=C3)C(C)O)CC(O)=O)CC4=CC=CC=C4)C(NC(C(NC(=O)NC(C(NC(C(=O)SCCNC(C)=O)CC(C)C)=O)CC(C)C)=O)CC5=C[N]C6=CC=CC=C56)=O
InChI InChI=1S/C74H95N13O17S/c1-42(2)34-54(67(96)83-59(35-43(3)4)73(102)105-33-31-75-46(7)89)84-74(103)86-69(98)56(38-50-40-76-53-23-16-15-22-52(50)53)81-68(97)55(36-49-25-28-51(104-8)29-26-49)82-70(99)60-24-17-32-87(60)72(101)58(37-48-20-13-10-14-21-48)79-62(91)41-77-66(95)57(39-63(92)93)80-65(94)44(5)78-71(100)64(45(6)88)85-61(90)30-27-47-18-11-9-12-19-47/h9-16,18-23,25-30,40,42-45,54-60,64,76,88H,17,24,31-39,41H2,1-8H3,(H,75,89)(H,77,95)(H,78,100)(H,79,91)(H,80,94)(H,81,97)(H,82,99)(H,83,96)(H,85,90)(H,92,93)(H2,84,86,98,103)/b30-27+
InChIKey VDHCBNNLJGQPCC-KDJFERLWSA-N
Other name(s)
________________________________________________________________________________________________
MW|1470.70
Formula|C74H95N13O17S
CAS_number|
PubChem|
UniChem|VDHCBNNLJGQPCC-KDJFERLWSA-N
IUPHAR|
Wikipedia|

Target
Families | Skyllamycin-like-precursor ligand of proteins in family: Thioesterase
Protein | strsq-a0a1j0r317

References:
Search PubMed for references concerning: Skyllamycin-like-precursor
    Title: Functional Characterization and Crystal Structure of the Bifunctional Thioesterase Catalyzing Epimerization and Cyclization in Skyllamycin Biosynthesis
    Yu J, Juan S, Chi C, Liu T, Geng T, Cai Z, Dong W, Shi C, Ma X and Ma M <6 more author(s)>
    Ref: ACS Catal, 11:11733, 2021 : PubMed