Rifapentine
General
Type : Pro-Drug || Drug || Not A\/B H target || Piperazine || Antibiotic
Chemical_Nomenclature : [(7S,9E,11S,12R,13S,14R,15R,16R,17S,18S,19E,21Z)-26-[(E)-(4-cyclopentylpiperazin-1-yl)iminomethyl]-2,15,17,27,29-pentahydroxy-11-methoxy-3,7,12,14,16,18,22-heptamethyl-6,23-dioxo-8,30-dioxa-24-azatetracyclo[23.3.1.14,7.05,28]triaconta-1(29),2,4,9,19,21,25,27-octaen-13-yl] acetate
Canonical SMILES : CC1C=CC=C(C(=O)NC2=C(C(=C3C(=C2O)C(=C(C4=C3C(=O)C(O4)
InChI : InChI=1S\/C47H64N4O12\/c1-24-13-12-14-25(2)46(59)49-37-32(23-48-51-20-18-50(19-21-51)31-15-10-11-16-31)41(56)34-35(42(37)57)40(55)29(6)44-36(34)45(58)47(8,63-44)61-22-17-33(60-9)26(3)43(62-30(7)52)28(5)39(54)27(4)38(24)53\/h12-14,17,22-24,26-28,31,33,38-39,43,53-57H,10-11,15-16,18-21H2,1-9H3,(H,49,59)\/b13-12+,22-17+,25-14-,48-23+\/t24-,26+,27+,28+,33-,38-,39+,43+,47-\/m0\/s1
InChIKey : WDZCUPBHRAEYDL-GZAUEHORSA-N
Other name(s) : Priftin, Rifapentin, Cyclopentylrifampicin, CHEBI:45304, CHEMBL1660, SCHEMBL41590, D00879, DB01201
Target
Families : Arylacetamide_deacetylase
References (2)
| Title : A Population Pharmacokinetic Analysis Shows that Arylacetamide Deacetylase (AADAC) Gene Polymorphism and HIV Infection Affect the Exposure of Rifapentine - Francis_2019_Antimicrob.Agents.Chemother_63_e01964 |
| Author(s) : Francis J , Zvada SP , Denti P , Hatherill M , Charalambous S , Mungofa S , Dawson R , Dorman S , Gupte N , Wiesner L , Jindani A , Harrison TS , Olagunju A , Egan D , Owen A , McIlleron HM |
| Ref : Antimicrobial Agents & Chemotherapy , 63 : , 2019 |
| Abstract : Francis_2019_Antimicrob.Agents.Chemother_63_e01964 |
| ESTHER : Francis_2019_Antimicrob.Agents.Chemother_63_e01964 |
| PubMedSearch : Francis_2019_Antimicrob.Agents.Chemother_63_e01964 |
| PubMedID: 30670438 |
| Gene_locus related to this paper: human-AADAC |
| Title : Human arylacetamide deacetylase is responsible for deacetylation of rifamycins: rifampicin, rifabutin, and rifapentine - Nakajima_2011_Biochem.Pharmacol_82_1747 |
| Author(s) : Nakajima A , Fukami T , Kobayashi Y , Watanabe A , Nakajima M , Yokoi T |
| Ref : Biochemical Pharmacology , 82 :1747 , 2011 |
| Abstract : Nakajima_2011_Biochem.Pharmacol_82_1747 |
| ESTHER : Nakajima_2011_Biochem.Pharmacol_82_1747 |
| PubMedSearch : Nakajima_2011_Biochem.Pharmacol_82_1747 |
| PubMedID: 21856291 |
| Gene_locus related to this paper: human-AADAC |