Type : Pro-Drug || Drug || Propionate
Chemical_Nomenclature : propan-2-yl 2-[4-(4-chlorobenzoyl)phenoxy]-2-methylpropanoate
Canonical SMILES : CC(C)OC(=O)C(C)(C)OC1=CC=C(C=C1)C(=O)C2=CC=C(C=C2)Cl
InChI : InChI=1S\/C20H21ClO4\/c1-13(2)24-19(23)20(3,4)25-17-11-7-15(8-12-17)18(22)14-5-9-16(21)10-6-14\/h5-13H,1-4H3
InChIKey : YMTINGFKWWXKFG-UHFFFAOYSA-N
Other name(s) : Procetofen, Lipantil, Tricor
Families : Carb_B_Chordata
Title : Human carboxylesterase 1A plays a predominant role in hydrolysis of the anti-dyslipidemia agent fenofibrate in humans - Li_2023_Drug.Metab.Dispos__ |
Author(s) : Li HX , Sun MR , Zhang Y , Song LL , Zhang F , Song YQ , Hou XD , Ge GB |
Ref : Drug Metabolism & Disposition: The Biological Fate of Chemicals , : , 2023 |
Abstract : Li_2023_Drug.Metab.Dispos__ |
ESTHER : Li_2023_Drug.Metab.Dispos__ |
PubMedSearch : Li_2023_Drug.Metab.Dispos__ |
PubMedID: 37550069 |
Gene_locus related to this paper: human-CES1 |
Title : Maternally inherited diabetes and deafness coexists with lipoprotein lipase gene mutation-associated severe hyperlipidemia that was resistant to fenofibrate and atorvastatin, but sensitive to bezafibrate: A case report - Zhang_2022_J.Diabetes.Investig_13_397 |
Author(s) : Zhang X , Chen Y , Tong N , Shao Q , Zhou Y , Mu T , Yang X , Zhang Y |
Ref : J Diabetes Investig , 13 :397 , 2022 |
Abstract : Zhang_2022_J.Diabetes.Investig_13_397 |
ESTHER : Zhang_2022_J.Diabetes.Investig_13_397 |
PubMedSearch : Zhang_2022_J.Diabetes.Investig_13_397 |
PubMedID: 34460997 |
Gene_locus related to this paper: human-LPL |
Title : Effects of simvastatin and fenofibrate on butyrylcholinesterase activity in the brain, plasma, and liver of normolipidemic and hyperlipidemic rats - Vuksic_2019_Arh.Hig.Rada.Toksikol_70_30 |
Author(s) : Vuksic A , Lovric J , Konjevoda P , Blazevic N , Bilusic M , Bradamante V |
Ref : Arh Hig Rada Toksikol , 70 :30 , 2019 |
Abstract : Vuksic_2019_Arh.Hig.Rada.Toksikol_70_30 |
ESTHER : Vuksic_2019_Arh.Hig.Rada.Toksikol_70_30 |
PubMedSearch : Vuksic_2019_Arh.Hig.Rada.Toksikol_70_30 |
PubMedID: 30956215 |
Title : Comparison of substrate specificity among human arylacetamide deacetylase and carboxylesterases - Fukami_2015_Eur.J.Pharm.Sci_78_47 |
Author(s) : Fukami T , Kariya M , Kurokawa T , Iida A , Nakajima M |
Ref : Eur J Pharm Sci , 78 :47 , 2015 |
Abstract : Fukami_2015_Eur.J.Pharm.Sci_78_47 |
ESTHER : Fukami_2015_Eur.J.Pharm.Sci_78_47 |
PubMedSearch : Fukami_2015_Eur.J.Pharm.Sci_78_47 |
PubMedID: 26164127 |
Gene_locus related to this paper: human-AADAC , human-CES1 , human-CES2 |
Title : Lipase maturation factor 1: its expression in Zucker diabetic rats, and effects of metformin and fenofibrate - Forcheron_2009_Diabetes.Metab_35_452 |
Author(s) : Forcheron F , Basset A , Del Carmine P , Beylot M |
Ref : Diabetes Metab , 35 :452 , 2009 |
Abstract : Forcheron_2009_Diabetes.Metab_35_452 |
ESTHER : Forcheron_2009_Diabetes.Metab_35_452 |
PubMedSearch : Forcheron_2009_Diabetes.Metab_35_452 |
PubMedID: 19854668 |
Title : Effect of fenofibrate on plasma lipoprotein composition and kinetics in patients with complete hepatic lipase deficiency - Ruel_2005_Arterioscler.Thromb.Vasc.Biol_25_2600 |
Author(s) : Ruel IL , Lamarche B , Mauger JF , Badellino KO , Cohn JS , Marcil M , Couture P |
Ref : Arterioscler Thromb Vasc Biol , 25 :2600 , 2005 |
Abstract : Ruel_2005_Arterioscler.Thromb.Vasc.Biol_25_2600 |
ESTHER : Ruel_2005_Arterioscler.Thromb.Vasc.Biol_25_2600 |
PubMedSearch : Ruel_2005_Arterioscler.Thromb.Vasc.Biol_25_2600 |
PubMedID: 16224048 |
Gene_locus related to this paper: human-LIPC |
Title : The effect of micronised fenofibrate on paraoxonase activity in patients with coronary heart disease - Paragh_2003_Diabetes.Metab_29_613 |
Author(s) : Paragh G , Seres I , Harangi M , Balogh Z , Illyes L , Boda J , Szilvassy Z , Kovacs P |
Ref : Diabetes Metab , 29 :613 , 2003 |
Abstract : Paragh_2003_Diabetes.Metab_29_613 |
ESTHER : Paragh_2003_Diabetes.Metab_29_613 |
PubMedSearch : Paragh_2003_Diabetes.Metab_29_613 |
PubMedID: 14707891 |
Title : The effect of peroxisome proliferator-activated receptors alpha (PPARalpha) agonist, fenofibrate, on lipid peroxidation, total antioxidant capacity, and plasma paraoxonase 1 (PON 1) activity - Beltowski_2002_J.Physiol.Pharmacol_53_463 |
Author(s) : Beltowski J , Wojcicka G , Mydlarczyk M , Jamroz A |
Ref : J Physiol Pharmacol , 53 :463 , 2002 |
Abstract : Beltowski_2002_J.Physiol.Pharmacol_53_463 |
ESTHER : Beltowski_2002_J.Physiol.Pharmacol_53_463 |
PubMedSearch : Beltowski_2002_J.Physiol.Pharmacol_53_463 |
PubMedID: 12369742 |
Title : Effect of apolipoprotein E, peroxisome proliferator-activated receptor alpha and lipoprotein lipase gene mutations on the ability of fenofibrate to improve lipid profiles and reach clinical guideline targets among hypertriglyceridemic patients - Brisson_2002_Pharmacogenet_12_313 |
Author(s) : Brisson D , Ledoux K , Bosse Y , St-Pierre J , Julien P , Perron P , Hudson TJ , Vohl MC , Gaudet D |
Ref : Pharmacogenetics , 12 :313 , 2002 |
Abstract : Brisson_2002_Pharmacogenet_12_313 |
ESTHER : Brisson_2002_Pharmacogenet_12_313 |
PubMedSearch : Brisson_2002_Pharmacogenet_12_313 |
PubMedID: 12042669 |
Title : Regulation of lipid metabolism and gene expression by fenofibrate in hamsters. - |
Author(s) : Guo Q , Wang PR , Milot DP , Ippolito MC , Hernandez M , Burton CA , Wright SD , Chao Y |
Ref : Biochimica & Biophysica Acta , 1533 :220 , 2001 |
PubMedID: 11731332 |
Title : Down-regulation of hepatic lipase gene expression and activity by fenofibrate - Staels_1992_Biochim.Biophys.Acta_24_227 |
Author(s) : Staels B , Peinado-Onsurbe J , Auwerx J |
Ref : Biochimica & Biophysica Acta , 24 :227 , 1992 |
Abstract : Staels_1992_Biochim.Biophys.Acta_24_227 |
ESTHER : Staels_1992_Biochim.Biophys.Acta_24_227 |
PubMedSearch : Staels_1992_Biochim.Biophys.Acta_24_227 |
PubMedID: 1739751 |