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Substrate Report for: DHDMP

Substrate of peroxisomal acyl-coenzyme A (CoA) hydrolase MpaH. Intermediate in the biosynthetic pathway of Mycophenolic acid (MPA) from filamentous fungi is the first natural product antibiotic


General
Type Natural, Benzofuran
Chemical_Nomenclature (4R)-7-hydroxy-4,6-dimethyl-4-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trienyl]-3H-2-benzofuran-1,5-dione
Canonical SMILES CC1=C(C2=C(COC2=O)C(C1=O)(C)CC=C(C)CCC=C(C)CCC=C(C)C)O
InChI InChI=1S/C25H34O4/c1-16(2)9-7-10-17(3)11-8-12-18(4)13-14-25(6)20-15-29-24(28)21(20)22(26)19(5)23(25)27/h9,11,13,26H,7-8,10,12,14-15H2,1-6H3/b17-11+,18-13+/t25-/m1/s1
InChIKey YRKOMSPAXUNNRG-CYIFYSEMSA-N
Other name(s) Farnesyl-5,7-dihydroxy-4,6-dimethylphthalide
________________________________________________________________________________________________
MW|398.5
Formula|C25H34O4
CAS_number|
PubChem|91819848
UniChem|YRKOMSPAXUNNRG-CYIFYSEMSA-N
IUPHAR|
Wikipedia|

Target
Families | DHDMP ligand of proteins in family: MpaH
Protein | penbr-mpaH

References:
Search PubMed for references concerning: DHDMP
    Title: Compartmentalized biosynthesis of mycophenolic acid
    Zhang W, Du L, Qu Z, Zhang X, Li F, Li Z, Qi F, Wang X, Jiang Y and Li S <6 more author(s)>
    Ref: Proc Natl Acad Sci U S A, 116:13305, 2019 : PubMed

            

    Title: Complete biosynthetic pathway of anditomin: nature's sophisticated synthetic route to a complex fungal meroterpenoid
    Matsuda Y, Wakimoto T, Mori T, Awakawa T, Abe I
    Ref: Journal of the American Chemical Society, 136:15326, 2014 : PubMed