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Substrate Report for: Chloramphenicol-diacetate

chloramphenicol acetyltransferase (CAT) transfers acetate to chloramphenicol thereby inactivating the antibiotic. .EstDL136 catalyzed the deacetylation of 1- and 3- acetyl and 1,3-diacetyl derivates counteracting CAT and restoring Chloramphenicol. EstDL136 also acts as a chloramphenicol hydrolase.It cleaves the amide linkage at C2 of chloramphenicol and thereby confers resistance to bacteria


General
Type Antibiotic, Acetate, pNP
Chemical_Nomenclature [(2~{R},3~{R})-3-acetyloxy-2-[(2,2-dichloroacetyl)amino]-3-(4-nitrophenyl)propyl] acetate
Canonical SMILES CC(=O)OCC(C(C1=CC=C(C=C1)[N+](=O)[O-])OC(=O)C)NC(=O)C(Cl)Cl
InChI InChI=1S/C15H16Cl2N2O7/c1-8(20)25-7-12(18-15(22)14(16)17)13(26-9(2)21)10-3-5-11(6-4-10)19(23)24/h3-6,12-14H,7H2,1-2H3,(H,18,22)/t12-,13-/m1/s1
InChIKey RBAMFWWUJRFUPC-CHWSQXEVSA-N
Other name(s) 1,3-Diacetylchloramphenicol ; 1,3-Diacetyl chloramphenicol ; 1,3-Dacp ; Chloramphenicol diacetate ; AC1Q3GZE ; AC1L4OI1
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MW|407.2
Formula|C15H16Cl2N2O7
CAS_number|10318-17-9
PubChem|160933
UniChem|RBAMFWWUJRFUPC-CHWSQXEVSA-N
IUPHAR|
Wikipedia|

Target

References:
Search PubMed for references concerning: Chloramphenicol-diacetate
    Title: Crystal structure of chloramphenicol-metabolizing enzyme EstDL136 from a metagenome
    Kim SH, Kang PA, Han K, Lee SW, Rhee S
    Ref: PLoS ONE, 14:e0210298, 2019 : PubMed