CHR-2863
General
Type : Drug
Chemical_Nomenclature : cyclopentyl (2S)-2-[[(2R)-2-[(1S)-2-(hydroxyamino)-1-methoxy-2-oxoethyl]-4-methylpentanoyl]amino]-2-phenylacetate
Canonical SMILES : CC(C)CC(C(C(=O)NO)OC)C(=O)NC(C1=CC=CC=C1)C(=O)OC2CCCC2
InChI : InChI=1S\/C22H32N2O6\/c1-14(2)13-17(19(29-3)21(26)24-28)20(25)23-18(15-9-5-4-6-10-15)22(27)30-16-11-7-8-12-16\/h4-6,9-10,14,16-19,28H,7-8,11-13H2,1-3H3,(H,23,25)(H,24,26)\/t17-,18+,19+\/m1\/s1
InChIKey : NYGGUGZLUBNLTJ-QYZOEREBSA-N
Other name(s) : CHR 2863, CHR2863, Cyclopentyl (2S)-2-[[(2R)-2-[(1S)-2-(hydroxyamino)-1-methoxy-2-oxo-ethyl]-4-methyl-pentanoyl]amino]-2-phenyl-acetate
MW : 420.49
Formula : C22H32N2O6
CAS_number :
PubChem :
UniChem :
Iuphar :
Target
Families : Carb_B_Chordata
References (2)
| Title : Multifactorial resistance to aminopeptidase inhibitor prodrug CHR2863 in myeloid leukemia cells: down-regulation of carboxylesterase 1, drug sequestration in lipid droplets and pro-survival activation ERK\/Akt\/mTOR - Verbrugge_2016_Oncotarget_7_5240 |
| Author(s) : Verbrugge SE , Al M , Assaraf YG , Kammerer S , Chandrupatla DM , Honeywell R , Musters RP , Giovannetti E , O'Toole T , Scheffer GL , Krige D , de Gruijl TD , Niessen HW , Lems WF , Kramer PA , Scheper RJ , Cloos J , Ossenkoppele GJ , Peters GJ , Jansen G |
| Ref : Oncotarget , 7 :5240 , 2016 |
| Abstract : Verbrugge_2016_Oncotarget_7_5240 |
| ESTHER : Verbrugge_2016_Oncotarget_7_5240 |
| PubMedSearch : Verbrugge_2016_Oncotarget_7_5240 |
| PubMedID: 26496029 |
| Title : The aminopeptidase inhibitor CHR-2863 is an orally bioavailable inhibitor of murine malaria - Skinner-Adams_2012_Antimicrob.Agents.Chemother_56_3244 |
| Author(s) : Skinner-Adams TS , Peatey CL , Anderson K , Trenholme KR , Krige D , Brown CL , Stack C , Nsangou DM , Mathews RT , Thivierge K , Dalton JP , Gardiner DL |
| Ref : Antimicrobial Agents & Chemotherapy , 56 :3244 , 2012 |
| Abstract : Skinner-Adams_2012_Antimicrob.Agents.Chemother_56_3244 |
| ESTHER : Skinner-Adams_2012_Antimicrob.Agents.Chemother_56_3244 |
| PubMedSearch : Skinner-Adams_2012_Antimicrob.Agents.Chemother_56_3244 |
| PubMedID: 22450967 |