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Substrate Report for: Benzoylthiocholine

General
Type Trimethylammonium, Choline ester, Chromogen
Chemical_Nomenclature 2-benzoylsulfanylethyl(trimethyl)azanium
Canonical SMILES C[N+](C)(C)CCSC(=O)C1=CC=CC=C1
InChI InChI=1S/C12H18NOS/c1-13(2,3)9-10-15-12(14)11-7-5-4-6-8-11/h4-8H,9-10H2,1-3H3/q+1
InChIKey WHFRQMFIMVEPIU-UHFFFAOYSA-N
Other name(s) Ethanaminium, 2-(benzoylthio)-N,N,N-trimethyl- ; AGN-PC-00OHZ6 ; CTK0F4669 ; ZINC2527990 ; OR214358
________________________________________________________________________________________________
MW|224.34
Formula|C12H18NOS
CAS_number|13365-71-4
PubChem|13960253
UniChem|WHFRQMFIMVEPIU-UHFFFAOYSA-N
IUPHAR|
Wikipedia|

Target
Families | Benzoylthiocholine ligand of proteins in family: BCHE, ACHE
Protein | human-BCHE

References:
Search PubMed for references concerning: Benzoylthiocholine

2 more
    Title: Hydrolysis of oxo- and thio-esters by human butyrylcholinesterase
    Masson P, Froment MT, Gillon E, Nachon F, Lockridge O, Schopfer LM
    Ref: Biochimica & Biophysica Acta, 1774:16, 2007 : PubMed

            

    Title: Development and application of serum cholinesterase activity measurement using benzoylthiocholine iodide
    Osawa S, Kariyone K, Ichihara F, Arai K, Takagasa N, Ito H
    Ref: Clinica Chimica Acta, 351:65, 2005 : PubMed

            

    Title: Specificity and orientation of trigonal carboxyl esters and tetrahedral alkylphosphonyl esters in cholinesterases
    Hosea NA, Berman HA, Taylor P
    Ref: Biochemistry, 34:11528, 1995 : PubMed

            


mouse-ACHE
MutationKmKcatConditionPaper
> Mutations for mouse-ACHE (7)

mouse-BCHE
MutationKmKcatConditionPaper
WT 27 uM 3800 /min 100mM NaPhosphate Ph7.0 T22C Hosea_1995_Biochemistry_34_11528

WT Kinetics
Kinetic parametersKmKcatConditionsPapers
mouse-ACHE46 uM30 /min100mM NaPhosphate Ph7.0 T22C Hosea_1995_Biochemistry_34_11528
mouse-BCHE27 uM3800 /min100mM NaPhosphate Ph7.0 T22C Hosea_1995_Biochemistry_34_11528