Aspirin
General
Type : Salicylic || Acetate || Benzoate || Drug
Chemical_Nomenclature : 2-acetyloxybenzoic acid
Canonical SMILES : CC(=O)OC1=CC=CC=C1C(=O)O
InChI : InChI=1S\/C9H8O4\/c1-6(10)13-8-5-3-2-4-7(8)9(11)12\/h2-5H,1H3,(H,11,12)
InChIKey : BSYNRYMUTXBXSQ-UHFFFAOYSA-N
Other name(s) : Acetylsalicylic acid, 2-Acetoxybenzoic acid, Ecotrin, Acenterine, Acetosal, 2-(Acetyloxy)benzoic acid, salicylic acid acetate
Target
Families : BCHE, Carb_B_Chordata
References (11)
| Title : Aspirin Hydrolysis in Plasma Is a Variable Function of Butyrylcholinesterase and Platelet-activating Factor Acetylhydrolase 1b2 (PAFAH1b2) - Zhou_2013_J.Biol.Chem_288_11940 |
| Author(s) : Zhou G , Marathe GK , Hartiala J , Hazen SL , Allayee H , Tang WH , McIntyre TM |
| Ref : Journal of Biological Chemistry , 288 :11940 , 2013 |
| Abstract : Zhou_2013_J.Biol.Chem_288_11940 |
| ESTHER : Zhou_2013_J.Biol.Chem_288_11940 |
| PubMedSearch : Zhou_2013_J.Biol.Chem_288_11940 |
| PubMedID: 23508960 |
| Title : Reaction of human albumin with aspirin in vitro: mass spectrometric identification of acetylated lysines 199, 402, 519, and 545 - Liyasova_2010_Biochem.Pharmacol_79_784 |
| Author(s) : Liyasova MS , Schopfer LM , Lockridge O |
| Ref : Biochemical Pharmacology , 79 :784 , 2010 |
| Abstract : Liyasova_2010_Biochem.Pharmacol_79_784 |
| ESTHER : Liyasova_2010_Biochem.Pharmacol_79_784 |
| PubMedSearch : Liyasova_2010_Biochem.Pharmacol_79_784 |
| PubMedID: 19836360 |
| Title : Serum aspirin esterase is strongly associated with glucose and lipids in healthy subjects: different association patterns in subjects with type 2 diabetes mellitus - Kotani_2010_Diabetol.Metab.Syndr_2_50 |
| Author(s) : Kotani K , Kimura S , Ebara T , Caccavello R , Gugliucci A |
| Ref : Diabetol Metab Syndr , 2 :50 , 2010 |
| Abstract : Kotani_2010_Diabetol.Metab.Syndr_2_50 |
| ESTHER : Kotani_2010_Diabetol.Metab.Syndr_2_50 |
| PubMedSearch : Kotani_2010_Diabetol.Metab.Syndr_2_50 |
| PubMedID: 20659351 |
| Title : Discovery of a true aspirin prodrug - Moriarty_2008_J.Med.Chem_51_7991 |
| Author(s) : Moriarty LM , Lally MN , Carolan CG , Jones M , Clancy JM , Gilmer JF |
| Ref : Journal of Medicinal Chemistry , 51 :7991 , 2008 |
| Abstract : Moriarty_2008_J.Med.Chem_51_7991 |
| ESTHER : Moriarty_2008_J.Med.Chem_51_7991 |
| PubMedSearch : Moriarty_2008_J.Med.Chem_51_7991 |
| PubMedID: 19049433 |
| Title : Evaluation of nitrate-substituted pseudocholine esters of aspirin as potential nitro-aspirins - Gilmer_2007_Bioorg.Med.Chem.Lett_17_3217 |
| Author(s) : Gilmer JF , Moriarty LM , Clancy JM |
| Ref : Bioorganic & Medicinal Chemistry Lett , 17 :3217 , 2007 |
| Abstract : Gilmer_2007_Bioorg.Med.Chem.Lett_17_3217 |
| ESTHER : Gilmer_2007_Bioorg.Med.Chem.Lett_17_3217 |
| PubMedSearch : Gilmer_2007_Bioorg.Med.Chem.Lett_17_3217 |
| PubMedID: 17376682 |
| Title : Isosorbide-based aspirin prodrugs. II. Hydrolysis kinetics of isosorbide diaspirinate - Gilmer_2002_Eur.J.Pharm.Sci_16_297 |
| Author(s) : Gilmer JF , Moriarty LM , Lally MN , Clancy JM |
| Ref : Eur J Pharm Sci , 16 :297 , 2002 |
| Abstract : Gilmer_2002_Eur.J.Pharm.Sci_16_297 |
| ESTHER : Gilmer_2002_Eur.J.Pharm.Sci_16_297 |
| PubMedSearch : Gilmer_2002_Eur.J.Pharm.Sci_16_297 |
| PubMedID: 12208460 |
| Title : Synthesis, hydrolysis kinetics and anti-platelet effects of isosorbide mononitrate derivatives of aspirin - Gilmer_2001_Eur.J.Pharm.Sci_14_221 |
| Author(s) : Gilmer JF , Moriarty LM , McCafferty DF , Clancy JM |
| Ref : Eur J Pharm Sci , 14 :221 , 2001 |
| Abstract : Gilmer_2001_Eur.J.Pharm.Sci_14_221 |
| ESTHER : Gilmer_2001_Eur.J.Pharm.Sci_14_221 |
| PubMedSearch : Gilmer_2001_Eur.J.Pharm.Sci_14_221 |
| PubMedID: 11576827 |
| Title : Butyrylcholinesterase-catalysed hydrolysis of aspirin, a negatively charged ester, and aspirin-related neutral esters - Masson_1998_Biochim.Biophys.Acta_1387_41 |
| Author(s) : Masson P , Froment MT , Fortier PL , Visicchio JE , Bartels CF , Lockridge O |
| Ref : Biochimica & Biophysica Acta , 1387 :41 , 1998 |
| Abstract : Masson_1998_Biochim.Biophys.Acta_1387_41 |
| ESTHER : Masson_1998_Biochim.Biophys.Acta_1387_41 |
| PubMedSearch : Masson_1998_Biochim.Biophys.Acta_1387_41 |
| PubMedID: 9748494 |
| Title : Sex differences in the enzymatic hydrolysis of acetylsalicylic acid by microsomes from various rat tissues - Vargas_1997_J.Appl.Toxicol_17_347 |
| Author(s) : Vargas Loza AM , Montes de Oca EI , Posadas del Rio FA |
| Ref : Journal of Applied Toxicology , 17 :347 , 1997 |
| Abstract : Vargas_1997_J.Appl.Toxicol_17_347 |
| ESTHER : Vargas_1997_J.Appl.Toxicol_17_347 |
| PubMedSearch : Vargas_1997_J.Appl.Toxicol_17_347 |
| PubMedID: 9418940 |
| Title : Genetic variants of human serum cholinesterase influence metabolism of the muscle relaxant succinylcholine. - Lockridge_1990_Pharmacol.Ther_47_35 |
| Author(s) : Lockridge O |
| Ref : Pharmacol Ther , 47 :35 , 1990 |
| Abstract : Lockridge_1990_Pharmacol.Ther_47_35 |
| ESTHER : Lockridge_1990_Pharmacol.Ther_47_35 |
| PubMedSearch : Lockridge_1990_Pharmacol.Ther_47_35 |
| PubMedID: 2195556 |
| Gene_locus related to this paper: human-BCHE |
| Title : Prediction of drug sensitivity in individuals with atypical serum cholinesterase based on in vitro biochemical studies - Valentino_1981_Biochem.Pharmacol_30_1643 |
| Author(s) : Valentino RJ , Lockridge O , Eckerson HW , La Du BN |
| Ref : Biochemical Pharmacology , 30 :1643 , 1981 |
| Abstract : Valentino_1981_Biochem.Pharmacol_30_1643 |
| ESTHER : Valentino_1981_Biochem.Pharmacol_30_1643 |
| PubMedSearch : Valentino_1981_Biochem.Pharmacol_30_1643 |
| PubMedID: 7271851 |