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Substrate Report for: Ala-Pro-AFC

General
Type Peptide, Coumarin, Trifluoro, Pyrrolidine, Carboxamide
Chemical_Nomenclature 1-(2-aminopropanoyl)-N-[2-oxo-4-(trifluoromethyl)chromen-7-yl]pyrrolidine-2-carboxamide
Canonical SMILES CC(C(=O)N1CCCC1C(=O)NC2=CC3=C(C=C2)C(=CC(=O)O3)C(F)(F)F)N
InChI InChI=1S/C18H18F3N3O4/c1-9(22)17(27)24-6-2-3-13(24)16(26)23-10-4-5-11-12(18(19,20)21)8-15(25)28-14(11)7-10/h4-5,7-9,13H,2-3,6,22H2,1H3,(H,23,26)
InChIKey GGRRKBLWOMKWNS-UHFFFAOYSA-N
Other name(s) D-Ala-Pro-AFC ; H-Ala-Pro-AFC ; AP-AFC ; D-AP-AFC ; Ala-Pro-7-Amino-4-trifluoromethylcoumarin ; D-Ala-Pro-7-Amino-4-trifluoromethylcoumarin
________________________________________________________________________________________________
MW|397.34
Formula|C18H18F3N3O4
CAS_number|
PubChem|44135037
UniChem|GGRRKBLWOMKWNS-UHFFFAOYSA-N
IUPHAR|
Wikipedia|

Target
Families | Ala-Pro-AFC ligand of proteins in family: Prolylcarboxypeptidase, DPP4N_Peptidase_S9

References:
Search PubMed for references concerning: Ala-Pro-AFC
    Title: Antiplasmin-cleaving enzyme is a soluble form of fibroblast activation protein
    Lee KN, Jackson KW, Christiansen VJ, Lee CS, Chun JG, McKee PA
    Ref: Blood, 107:1397, 2006 : PubMed

            

    Title: N-linked glycosylation of dipeptidyl peptidase IV (CD26): effects on enzyme activity, homodimer formation, and adenosine deaminase binding
    Aertgeerts K, Ye S, Shi L, Prasad SG, Witmer D, Chi E, Sang BC, Wijnands RA, Webb DR, Swanson RV
    Ref: Protein Science, 13:145, 2004 : PubMed

            

    Title: Sequence, purification, and cloning of an intracellular serine protease, quiescent cell proline dipeptidase
    Underwood R, Chiravuri M, Lee H, Schmitz T, Kabcenell AK, Yardley K, Huber BT
    Ref: Journal of Biological Chemistry, 274:34053, 1999 : PubMed