[11C]-PMP
General
Type : Piperidine || PET probe || Propionate
Chemical_Nomenclature : (1-methylpiperidin-4-yl) propanoate
Canonical SMILES : CCC(=O)OC1CCN(CC1)C
InChI : InChI=1S\/C9H17NO2\/c1-3-9(11)12-8-4-6-10(2)7-5-8\/h8H,3-7H2,1-2H3\/i2-1
InChIKey : OVQSLAXVKJVHJO-JVVVGQRLSA-N
Other name(s) : [11C]-PMP, 11C-PMP, AC1O70VJ, [11C]PMP, CHEMBL2311156, [11C]MP4P, [(11)C]PMP, PMP, N-[(11)C]methyl-piperidin-4-yl propionate, N-(11)C-methyl-piperidin-4-yl propionate, 1-[11C]Methylpiperidin-4-yl propionate, [11C]-methyl-4-piperidinyl propionate
MW : 170.23
Formula : C9H17N
CAS_number :
PubChem :
UniChem :
Iuphar :
Target
Families : ACHE
References (14)
| Title : GABA(A) Receptor Benzodiazepine Binding Sites and Motor Impairments in Parkinson's Disease - Bohnen_2023_Brain.Sci_13_1711 |
| Author(s) : Bohnen NI , Barr J , Vangel R , Roytman S , Paalanen R , Frey KA , Scott PJH , Kanel P |
| Ref : Brain Sci , 13 :1711 , 2023 |
| Abstract : Bohnen_2023_Brain.Sci_13_1711 |
| ESTHER : Bohnen_2023_Brain.Sci_13_1711 |
| PubMedSearch : Bohnen_2023_Brain.Sci_13_1711 |
| PubMedID: 38137159 |
| Title : Structural and molecular cholinergic imaging markers of cognitive decline in Parkinson's disease - Schumacher_2023_Brain__ |
| Author(s) : Schumacher J , Kanel P , Dyrba M , Storch A , Bohnen NI , Teipel S , Grothe MJ |
| Ref : Brain , : , 2023 |
| Abstract : Schumacher_2023_Brain__ |
| ESTHER : Schumacher_2023_Brain__ |
| PubMedSearch : Schumacher_2023_Brain__ |
| PubMedID: 37403733 |
| Title : PET Imaging of Cholinergic Neurotransmission in Neurodegenerative Disorders - Tiepolt_2022_J.Nucl.Med_63_33S |
| Author(s) : Tiepolt S , Meyer PM , Patt M , Deuther-Conrad W , Hesse S , Barthel H , Sabri O |
| Ref : J Nucl Med , 63 :33S , 2022 |
| Abstract : Tiepolt_2022_J.Nucl.Med_63_33S |
| ESTHER : Tiepolt_2022_J.Nucl.Med_63_33S |
| PubMedSearch : Tiepolt_2022_J.Nucl.Med_63_33S |
| PubMedID: 35649648 |
| Title : The effect of LRRK2 mutations on the cholinergic system in manifest and premanifest stages of Parkinson's disease: a cross-sectional PET study - Liu_2018_Lancet.Neurol_17_309 |
| Author(s) : Liu SY , Wile DJ , Fu JF , Valerio J , Shahinfard E , McCormick S , Mabrouk R , Vafai N , McKenzie J , Neilson N , Perez-Soriano A , Arena JE , Cherkasova M , Chan P , Zhang J , Zabetian CP , Aasly JO , Wszolek ZK , McKeown MJ , Adam MJ , Ruth TJ , Schulzer M , Sossi V , Stoessl AJ |
| Ref : Lancet Neurol , 17 :309 , 2018 |
| Abstract : Liu_2018_Lancet.Neurol_17_309 |
| ESTHER : Liu_2018_Lancet.Neurol_17_309 |
| PubMedSearch : Liu_2018_Lancet.Neurol_17_309 |
| PubMedID: 29456161 |
| Title : PET probes for imaging brain acetylcholinesterase - Kikuchi_2013_J.Labelled.Comp.Radiopharm_56_172 |
| Author(s) : Kikuchi T , Okamura T , Zhang MR , Irie T |
| Ref : J Labelled Comp Radiopharm , 56 :172 , 2013 |
| Abstract : Kikuchi_2013_J.Labelled.Comp.Radiopharm_56_172 |
| ESTHER : Kikuchi_2013_J.Labelled.Comp.Radiopharm_56_172 |
| PubMedSearch : Kikuchi_2013_J.Labelled.Comp.Radiopharm_56_172 |
| PubMedID: 24285323 |
| Title : Cerebral acetylcholinesterase imaging: development of the radioprobes - Kikuchi_2007_Curr.Top.Med.Chem_7_1790 |
| Author(s) : Kikuchi T , Okamura T , Fukushi K , Takahashi K , Toyohara J , Okada M , Zhang MR , Irie T |
| Ref : Curr Top Med Chem , 7 :1790 , 2007 |
| Abstract : Kikuchi_2007_Curr.Top.Med.Chem_7_1790 |
| ESTHER : Kikuchi_2007_Curr.Top.Med.Chem_7_1790 |
| PubMedSearch : Kikuchi_2007_Curr.Top.Med.Chem_7_1790 |
| PubMedID: 17979787 |
| Title : Cognitive correlates of cortical cholinergic denervation in Parkinson's disease and parkinsonian dementia - Bohnen_2006_J.Neurol_253_242 |
| Author(s) : Bohnen NI , Kaufer DI , Hendrickson R , Ivanco LS , Lopresti BJ , Constantine GM , Mathis Ch A , Davis JG , Moore RY , DeKosky ST |
| Ref : Journal of Neurology , 253 :242 , 2006 |
| Abstract : Bohnen_2006_J.Neurol_253_242 |
| ESTHER : Bohnen_2006_J.Neurol_253_242 |
| PubMedSearch : Bohnen_2006_J.Neurol_253_242 |
| PubMedID: 16133720 |
| Title : Degree of inhibition of cortical acetylcholinesterase activity and cognitive effects by donepezil treatment in Alzheimer's disease - Bohnen_2005_J.Neurol.Neurosurg.Psychiatry_76_315 |
| Author(s) : Bohnen NI , Kaufer DI , Hendrickson R , Ivanco LS , Lopresti BJ , Koeppe RA , Meltzer CC , Constantine G , Davis JG , Mathis CA , DeKosky ST , Moore RY |
| Ref : Journal of Neurology Neurosurg Psychiatry , 76 :315 , 2005 |
| Abstract : Bohnen_2005_J.Neurol.Neurosurg.Psychiatry_76_315 |
| ESTHER : Bohnen_2005_J.Neurol.Neurosurg.Psychiatry_76_315 |
| PubMedSearch : Bohnen_2005_J.Neurol.Neurosurg.Psychiatry_76_315 |
| PubMedID: 15716518 |
| Title : Cognitive correlates of alterations in acetylcholinesterase in Alzheimer's disease - Bohnen_2005_Neurosci.Lett_380_127 |
| Author(s) : Bohnen NI , Kaufer DI , Hendrickson R , Ivanco LS , Lopresti B , Davis JG , Constantine G , Mathis CA , Moore RY , DeKosky ST |
| Ref : Neuroscience Letters , 380 :127 , 2005 |
| Abstract : Bohnen_2005_Neurosci.Lett_380_127 |
| ESTHER : Bohnen_2005_Neurosci.Lett_380_127 |
| PubMedSearch : Bohnen_2005_Neurosci.Lett_380_127 |
| PubMedID: 15854764 |
| Title : Kinetic modeling of N-[11C]methylpiperidin-4-yl propionate: alternatives for analysis of an irreversible positron emission tomography trace for measurement of acetylcholinesterase activity in human brain - Koeppe_1999_J.Cereb.Blood.Flow.Metab_19_1150 |
| Author(s) : Koeppe RA , Frey KA , Snyder SE , Meyer P , Kilbourn MR , Kuhl DE |
| Ref : Journal of Cerebral Blood Flow & Metabolism , 19 :1150 , 1999 |
| Abstract : Koeppe_1999_J.Cereb.Blood.Flow.Metab_19_1150 |
| ESTHER : Koeppe_1999_J.Cereb.Blood.Flow.Metab_19_1150 |
| PubMedSearch : Koeppe_1999_J.Cereb.Blood.Flow.Metab_19_1150 |
| PubMedID: 10532640 |
| Title : In vivo mapping of cerebral acetylcholinesterase activity in aging and Alzheimer's disease [see comments] - Kuhl_1999_Neurology_52_691 |
| Author(s) : Kuhl DE , Koeppe RA , Minoshima S , Snyder SE , Ficaro EP , Foster NL , Frey KA , Kilbourn MR |
| Ref : Neurology , 52 :691 , 1999 |
| Abstract : Kuhl_1999_Neurology_52_691 |
| ESTHER : Kuhl_1999_Neurology_52_691 |
| PubMedSearch : Kuhl_1999_Neurology_52_691 |
| PubMedID: 10078712 |
| Title : N-[11C]methylpiperidine esters as acetylcholinesterase substrates: an in vivo structure-reactivity study - Kilbourn_1998_Nucl.Med.Biol_25_755 |
| Author(s) : Kilbourn MR , Nguyen TB , Snyder SE , Sherman P |
| Ref : Nucl Med Biol , 25 :755 , 1998 |
| Abstract : Kilbourn_1998_Nucl.Med.Biol_25_755 |
| ESTHER : Kilbourn_1998_Nucl.Med.Biol_25_755 |
| PubMedSearch : Kilbourn_1998_Nucl.Med.Biol_25_755 |
| PubMedID: 9863563 |
| Title : Synthesis of 1-[11C]methylpiperidin-4-yl propionate ([11C]PMP) for in vivo measurements of acetylcholinesterase activity - Snyder_1998_Nucl.Med.Biol_25_751 |
| Author(s) : Snyder SE , Tluczek L , Jewett DM , Nguyen TB , Kuhl DE , Kilbourn MR |
| Ref : Nucl Med Biol , 25 :751 , 1998 |
| Abstract : Snyder_1998_Nucl.Med.Biol_25_751 |
| ESTHER : Snyder_1998_Nucl.Med.Biol_25_751 |
| PubMedSearch : Snyder_1998_Nucl.Med.Biol_25_751 |
| PubMedID: 9863562 |
| Title : In vivo studies of acetylcholinesterase activity using a labeled substrate, N-[11C]methylpiperdin-4-yl propionate ([11C]PMP) - Kilbourn_1996_Synapse_22_123 |
| Author(s) : Kilbourn MR , Snyder SE , Sherman PS , Kuhl DE |
| Ref : Synapse , 22 :123 , 1996 |
| Abstract : Kilbourn_1996_Synapse_22_123 |
| ESTHER : Kilbourn_1996_Synapse_22_123 |
| PubMedSearch : Kilbourn_1996_Synapse_22_123 |
| PubMedID: 8787128 |