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Substrate Report for: BzGFCM

Substrate analogue for the detection of specific prenylated methylated protein methyl esterase (PMPMEase) activity. Cholinesterases do not hydrolyse BzGFCM. roteins anchored to membranes via prenyl groups include yeast mating factors, the p21ras protein (the protein product of the ras oncogene), and the nuclear lamins, structural components of the lamina of the inner nuclear membrane


General
Type Sulfur compound, Propionate
Chemical_Nomenclature methyl (2R)-2-[(2-benzamidoacetyl)amino]-3-(3,7,11-trimethyldodeca-2,6,10-trienylsulfanyl)propanoate
Canonical SMILES CC(=CCCC(=CCCC(=CCSCC(C(=O)OC)NC(=O)CNC(=O)C1=CC=CC=C1)C)C)C
InChI InChI=1S/C28H40N2O4S/c1-21(2)11-9-12-22(3)13-10-14-23(4)17-18-35-20-25(28(33)34-5)30-26(31)19-29-27(32)24-15-7-6-8-16-24/h6-8,11,13,15-17,25H,9-10,12,14,18-20H2,1-5H3,(H,29,32)(H,30,31)/t25-/m0/s1
InChIKey RAZGLHZZDLHNLI-VWLOTQADSA-N
Other name(s) benzoyl-glycyl-farnesyl-cysteine methyl ester ; benzoyl-glycyl-farnesyl-cysteine-methyl-ester ; Bz-Gly-DL-Cys(Unk)-OMe ; N-(benzoylglycyl)-S-farnesyl-l-cysteine methyl ester ; methyl 2-[(2-benzamidoacetyl)amino]-3-(3,7,11-trimethyldodeca-2,6,10-trienylsulfanyl)propanoate
________________________________________________________________________________________________
MW|500.7
Formula|C28H40N2O4S
CAS_number|
PubChem|129661245
UniChem|RAZGLHZZDLHNLI-VWLOTQADSA-N
IUPHAR|
Wikipedia|

Target
Families | BzGFCM ligand of proteins in family: Carb_B_Chordata
Protein | pig-a0a1s6l967

References:
Search PubMed for references concerning: BzGFCM

1 more
    Title: Insights into the physiological role of pig liver esterase: isoenzymes show differences in the demethylation of prenylated proteins
    Brusehaber E, Bottcher D, Bornscheuer UT
    Ref: Bioorganic & Medicinal Chemistry, 17:7878, 2009 : PubMed

            

    Title: Liver prenylated methylated protein methyl esterase is the same enzyme as Sus scrofa carboxylesterase
    Oboh OT, Lamango NS
    Ref: J Biochem Mol Toxicol, 22:51, 2008 : PubMed

            

    Title: Liver prenylated methylated protein methyl esterase is an organophosphate-sensitive enzyme
    Lamango NS
    Ref: J Biochem Mol Toxicol, 19:347, 2005 : PubMed