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Structure Report for: 7SVO

Name|Human Dipeptidyl peptidase 8 (DPP8) - ICeD-1 (inducer of cell death-1) complex
Revelation date|05-Oct-2022
Family|DPP4N_Peptidase_S9: there are 829 genes in this family, 179 structure(s)
PDB File|ESTHER: header of PDB entry RCSB: Full entry
Keith P. Moore, Adam G. Schwaid et al. ICeD-1 and ICeD-2 (inducer of cell death-1 and 2) function by modulating DPP9 and activating the caspase recruitment domain family member 8 (CARD8) inflammasome, eliminating HIV-1 infected cells
Ligand|Inhibitor: ICeD-1 Ligand in structure: Ligplot


    Title: A Phenotypic Screen Identifies Potent DPP9 Inhibitors Capable of Killing HIV-1 Infected Cells
    Moore KP, Schwaid AG, Tudor M, Park S, Beshore DC, Converso A, Shipe WD, Anand R, Lan P and Balibar CJ <29 more author(s)>
    Ref: ACS Chemical Biology, :, 2022 : PubMed


Representative scheme of DPP4N_Peptidase_S9 structure and an image from PDBsum server

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PDB-Sum7SVO Previously Class, Architecture, Topology and Homologous superfamily - PDB-Sum server
FSSP7SVO Fold classification based on Structure-Structure alignment of Proteins - FSSP server
SCOP7SVO Structural Classification Of Protein - SCOP server
PROTEOPEDIA7svo 3D, interactive encyclopedia of proteins - PROTEOPEDIA server

Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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