Tree Display

AceDB Schema

XML Display


Structure Report for: 6YXI

Name|Structure of Notum in complex with a 1-(3-Chlorophenyl)-2,5-dimethyl-1H-pyrrole-3-carboxylic acid inhibitor
Revelation date|19-Aug-2020
Family|Pectinacetylesterase-Notum: there are 695 genes in this family, 143 structure(s)
PDB File|ESTHER: header of PDB entry RCSB: Full entry
Vecchia, L., Jones, E.Y., Ruza, R.R., Hillier, J., Zhao, Y.
Ligand|Inhibitor: Pyrrole-20i-6YXI Ligand in structure: Ligplot


    Title: Screening of a Custom-Designed Acid Fragment Library Identifies 1-Phenylpyrroles and 1-Phenylpyrrolidines as Inhibitors of Notum Carboxylesterase Activity
    Mahy W, Patel M, Steadman D, Woodward HL, Atkinson BN, Svensson F, Willis NJ, Flint A, Papatheodorou D and Fish PV <10 more author(s)>
    Ref: Journal of Medicinal Chemistry, 63:9464, 2020 : PubMed


Representative scheme of Pectinacetylesterase-Notum structure and an image from PDBsum server

no Image


PDB-Sum6YXI Previously Class, Architecture, Topology and Homologous superfamily - PDB-Sum server
FSSP6YXI Fold classification based on Structure-Structure alignment of Proteins - FSSP server
SCOP6YXI Structural Classification Of Protein - SCOP server
PROTEOPEDIA6yxi 3D, interactive encyclopedia of proteins - PROTEOPEDIA server

Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
For technical information about these pages see:
ESTHER Home Page and ACEDB Home Page
AcePerl Lincoln Stein Home Page

Acknowledgements and disclaimer