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Structure Report for: 6U37

Name|Structure of VX-phosphonylated hAChE in complex with oxime reactivator RS194B
Revelation date|12-Feb-2020
Family|ACHE: there are 545 genes in this family, 315 structure(s)
PDB File|ESTHER: header of PDB entry RCSB: Full entry
Kovalevsky, A., Gerlits, O., Radic, Z.
Ligand|Inhibitor: VX Ligand in structure: Ligplot Reactivator: RS194B Ligand in structure: Ligplot


    Title: Rational design, synthesis and evaluation of uncharged, smart bis-oxime antidotes of organophosphate-inhibited human acetylcholinesterase
    Gorecki L, Gerlits O, Kong X, Cheng X, Blumenthal DK, Taylor P, Ballatore C, Kovalevsky A, Radic Z
    Ref: Journal of Biological Chemistry, 295:4079, 2020 : PubMed


Representative scheme of ACHE structure and an image from PDBsum server


PDB-Sum6U37 Previously Class, Architecture, Topology and Homologous superfamily - PDB-Sum server
FSSP6U37 Fold classification based on Structure-Structure alignment of Proteins - FSSP server
SCOP6U37 Structural Classification Of Protein - SCOP server
PROTEOPEDIA6u37 3D, interactive encyclopedia of proteins - PROTEOPEDIA server

Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
For technical information about these pages see:
ESTHER Home Page and ACEDB Home Page
AcePerl Lincoln Stein Home Page

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