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Structure Report for: 6T2K

Name|Furano[2,3-d]prymidine amides as Notum inhibitors 2 (LP-922056)
Revelation date|01-Jan-2020
Family|Pectinacetylesterase-Notum: there are 695 genes in this family, 143 structure(s)
PDB File|ESTHER: header of PDB entry RCSB: Full entry
Zhao, Y., Jones, E.Y.
Ligand|Inhibitor: LP-922056 Ligand in structure: Ligplot


    Title: Scaffold-hopping identifies furano[2,3-d]pyrimidine amides as potent Notum inhibitors
    Atkinson BN, Steadman D, Mahy W, Zhao Y, Sipthorp J, Bayle ED, Svensson F, Papageorgiou G, Jeganathan F and Fish PV <4 more author(s)>
    Ref: Bioorganic & Medicinal Chemistry Lett, :126751, 2019 : PubMed


Representative scheme of Pectinacetylesterase-Notum structure and an image from PDBsum server

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PDB-Sum6T2K Previously Class, Architecture, Topology and Homologous superfamily - PDB-Sum server
FSSP6T2K Fold classification based on Structure-Structure alignment of Proteins - FSSP server
SCOP6T2K Structural Classification Of Protein - SCOP server
PROTEOPEDIA6t2k 3D, interactive encyclopedia of proteins - PROTEOPEDIA server

Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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