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Structure Report for: 6MVD

Name|Crystal structure of Lecithin:cholesterol acyltransferase (LCAT) in complex with isopropyl dodec-11-enylfluorophosphonate (IDFP) and a small molecule activator supersedes 6DTJ
Revelation date|05-Dec-2018
Family|PC-sterol_acyltransferase: there are 97 genes in this family, 14 structure(s)
PDB File|ESTHER: header of PDB entry RCSB: Full entry
Manthei, K.A., Yang, S., Baljinnyam, B., Chang, L., Glukhova, A., Yuan, W., Freeman, L.A., Shen, M., Maloney, D.J., Schwendeman, A., Remaley, A.T., Jadhav, A., Tesmer, J.J.G. There is a preprint available at Biorxiv
Ligand|Inhibitor: IDFPen Ligand in structure: Ligplot Ligand: H94 Ligand in structure: Ligplot


    Title: Molecular basis for activation of lecithin:cholesterol acyltransferase by a compound that increases HDL cholesterol
    Manthei KA, Yang SM, Baljinnyam B, Chang L, Glukhova A, Yuan W, Freeman LA, Maloney DJ, Schwendeman A and Tesmer JJ <2 more author(s)>
    Ref: Elife, 7:, 2018 : PubMed


Representative scheme of PC-sterol_acyltransferase structure and an image from PDBsum server

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PDB-Sum6MVD Previously Class, Architecture, Topology and Homologous superfamily - PDB-Sum server
FSSP6MVD Fold classification based on Structure-Structure alignment of Proteins - FSSP server
SCOP6MVD Structural Classification Of Protein - SCOP server
PROTEOPEDIA6mvd 3D, interactive encyclopedia of proteins - PROTEOPEDIA server

Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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