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Structure Report for: 6II2

Name|Crystal structure of alpha-beta hydrolase (ABH) and Makes Caterpillars Floppy (MCF)-Like effectors of Vibrio vulnificus MO6-24/O
Revelation date|07-Aug-2019
Family|6_AlphaBeta_hydrolase: there are 3808 genes in this family, 54 structure(s)
PDB File|ESTHER: header of PDB entry RCSB: Full entry
Lee, Y., Kim, B.S., Choi, S., Lee, E.Y., Park, S., Hwang, J., Kwon, Y., Hyung, J., Lee, C., Eom, S.H., Kim, M.H.
Precursor of a multifunctional toxin that causes destruction of the actin
cytoskeleton by covalent cross-linking of actin and inactivation of Rho GTPases
when translocated into the host cytoplasm. Upon translocation into the host
cell, undergoes autoprocessing in cis mediated by the peptidase C80 domain
(also named CPD domain). One of the liberated protein is an alpha/beta hydrolase
which has a phosphatidylinositol-3-phosphate-specific phospholipase A1
activity which inhibits autophagy and endosomal trafficking


    Title: Makes caterpillars floppy-like effector-containing MARTX toxins require host ADP-ribosylation factor (ARF) proteins for systemic pathogenicity
    Lee Y, Kim BS, Choi S, Lee EY, Park S, Hwang J, Kwon Y, Hyun J, Lee C and Kim MH <2 more author(s)>
    Ref: Proc Natl Acad Sci U S A, 116:18031, 2019 : PubMed


Representative scheme of 6_AlphaBeta_hydrolase structure and an image from PDBsum server

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PDB-Sum6II2 Previously Class, Architecture, Topology and Homologous superfamily - PDB-Sum server
FSSP6II2 Fold classification based on Structure-Structure alignment of Proteins - FSSP server
SCOP6II2 Structural Classification Of Protein - SCOP server
PROTEOPEDIA6ii2 3D, interactive encyclopedia of proteins - PROTEOPEDIA server

Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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