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Structure Report for: 6I0B

Name|Human butyrylcholinesterase in complex with the R enantiomer of a chlorotacrine-tryptophan multi-target inhibitor
Revelation date|27-Mar-2019
Family|BCHE: there are 125 genes in this family, 91 structure(s)
Gene_locus|human-BCHE
PDB File|ESTHER: header of PDB entry RCSB: Full entry
Comment|
Brazzolotto, X., Nachon, F.
Ligand|Inhibitor: Chlorotacrine-tryptophan-hybrid Ligand in structure: Ligplot


Reference

    Title: Novel tacrine-tryptophan hybrids: Multi-target directed ligands as potential treatment for Alzheimer's disease
    Chalupova K, Korabecny J, Bartolini M, Monti B, Lamba D, Caliandro R, Pesaresi A, Brazzolotto X, Gastellier AJ and Kuca K <25 more author(s)>
    Ref: Eur Journal of Medicinal Chemistry, 168:491, 2019 : PubMed

            



Representative scheme of BCHE structure and an image from PDBsum server



Databases

PDB-Sum6I0B Previously Class, Architecture, Topology and Homologous superfamily - PDB-Sum server
FSSP6I0B Fold classification based on Structure-Structure alignment of Proteins - FSSP server
SCOP6I0B Structural Classification Of Protein - SCOP server
PROTEOPEDIA6i0b 3D, interactive encyclopedia of proteins - PROTEOPEDIA server



Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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