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Structure Report for: 6H12

Name|Crystal structure of Torpedo californica ACHE complexed to 1-(6-Oxo-1,2,3,4,6,10b-hexahydropyrido[2,1-a]isoindol-10-yl)-3-(4-(((1-(2-((1,2,3,4-tetrahydroacridin-9-yl)amino)ethyl)-1H-1,2,3-triazol-4-yl)methoxy)methyl)pyridin-2-yl)urea
Revelation date|15-May-2019
Family|ACHE: there are 543 genes in this family, 316 structure(s)
PDB File|ESTHER: header of PDB entry RCSB: Full entry
Coquelle, N., Colletier, J.P.
Ligand|Inhibitor: 6H12-(R)2 Ligand in structure: Ligplot


    Title: Design, biological evaluation and X-ray crystallography of nanomolar multifunctional ligands targeting simultaneously acetylcholinesterase and glycogen synthase kinase-3
    Oukoloff K, Coquelle N, Bartolini M, Naldi M, Le Guevel R, Bach S, Josselin B, Ruchaud S, Catto M and Renard PY <9 more author(s)>
    Ref: Eur Journal of Medicinal Chemistry, 168:58, 2019 : PubMed


Representative scheme of ACHE structure and an image from PDBsum server


PDB-Sum6H12 Previously Class, Architecture, Topology and Homologous superfamily - PDB-Sum server
FSSP6H12 Fold classification based on Structure-Structure alignment of Proteins - FSSP server
SCOP6H12 Structural Classification Of Protein - SCOP server
PROTEOPEDIA6h12 3D, interactive encyclopedia of proteins - PROTEOPEDIA server

Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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