6EMI
Name : Crystal structure of a variant of human butyrylcholinesterase expressed in bacteria
Revelation date : 08-Nov-2017
Family : BCHE
Gene_locus : human-BCHE
PDB file : ESTHER: header of PDB entry RCSB: Full entry
Comment
Brazzolotto, X., Igert, A., Guillon, V., Santoni, G., Nachon, F. (47 substitutions)
(A7T,S48P,D54G,C66M,Q71T,L110M,I111V,H126P,Q176K,K180D,N188D,K190N,S191R,
S215P,F227A,T234M,L236P,Y237E,T250L,L274D,G283S,I305T,N342D,I356V,G360N,V377E,
D379E,Q380D,E387D,G390A,D391E,N397F,T406A,F409Y,S410A,W412H,F417Y,D454L,A459E,
S466E,V468M,K469R,S489Q,S495P,T508S,Q518H,T523N)
>HBChE-7
EDDIIITTKNGKVRGMNLTVFGGTVTAFLGIPYAQPPLGRLRFKKPQPLTKWSGIWNATKYANSCMQNIDTSFPGF
HGSEMWNPNTDLSEDCLYLNVWIPAPKPKNATVMVWIYGGGFQTGTSSLPVYDGKFLARVERVIVVSMNYRVGALG
FLALPGNPEAPGNMGLFDQQLALKWVQDNIAAFGGDPNRVTLFGESAGAASVSLHLLSPGSHPLFTRAILQSGSAN
APWAVMSPEEARNRTLNLAKLLGCSRENETEIIKCLRNKDPQEILDNEAFVVPYSTPLSVNFGPTVDGDFLTDMPD
TLLELGQFKKTQILVGVNKDEGTAFLVYGAPGFSKDNDSIITRKEFQEGLKVFFPNVSEFGKESILFHYTDEDEDR
PENYRDALAEVVGDYFFICPALEFAKKYAEHGNNAYFYYFEHRSSKLPWPEWMGVMHGYEIEFVFGLPLERRLNYT
KEEEILSREIMRRWANFAKYGNPNETQNNSTQWPVFKPTEQKYLTLNTESSRIMTKLRAQHCRFWNSFFPKV
Ligand :
References (1)
| Title : Bacterial Expression of Human Butyrylcholinesterase as a Tool for Nerve Agent Bioscavengers Development - Brazzolotto_2017_Molecules_22_ |
| Author(s) : Brazzolotto X , Igert A , Guillon V , Santoni G , Nachon F |
| Ref : Molecules , 22 : , 2017 |
| Abstract : Brazzolotto_2017_Molecules_22_ |
| ESTHER : Brazzolotto_2017_Molecules_22_ |
| PubMedSearch : Brazzolotto_2017_Molecules_22_ |
| PubMedID: 29077024 |
| Gene_locus related to this paper: human-BCHE |
Representative scheme of Prolylcarboxypeptidase structure and an image from PDBsum server
