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Structure Report for: 6AVV

Name|Crystal structure of Arabidopsis thaliana protein deacetylase AtSOBER1 wild type
Revelation date|27-Dec-2017
Family|LYsophospholipase_carboxylesterase: there are 350 genes in this family, 27 structure(s)
PDB File|ESTHER: header of PDB entry RCSB: Full entry
Burger et al. show that Acyl-protein thioesterase structures present a long tunnel for accommodation of long-chain fatty acids and release the product by use of a flexible loop tunnel lid. Homologous deacetylases use a hydrophobic residue to fix the lid and another residue to close the tunnel entrance. This causes loop rigidity changing the catalytic preference to deacetylation. SOBER1 is a protein deacetylase and not an acylprotein thioesterase


    Title: A hydrophobic anchor mechanism defines a deacetylase family that suppresses host response against YopJ effectors
    Burger M, Willige BC, Chory J
    Ref: Nat Commun, 8:2201, 2017 : PubMed


Representative scheme of LYsophospholipase_carboxylesterase structure and an image from PDBsum server


PDB-Sum6AVV Previously Class, Architecture, Topology and Homologous superfamily - PDB-Sum server
FSSP6AVV Fold classification based on Structure-Structure alignment of Proteins - FSSP server
SCOP6AVV Structural Classification Of Protein - SCOP server
PROTEOPEDIA6avv 3D, interactive encyclopedia of proteins - PROTEOPEDIA server

Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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