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Structure Report for: 5YE9

Name|The crystal structure of Lp-PLA2 in complex with a novel inhibitor
Revelation date|25-Jul-2018
Family|PAF-Acetylhydrolase: there are 149 genes in this family, 35 structure(s)
PDB File|ESTHER: header of PDB entry RCSB: Full entry
Liu, Q.F.,, Xu, Y.C.
Ligand|Inhibitor: CHEMBL4075815 Ligand in structure: Ligplot


    Title: Structure-Guided Discovery of Novel, Potent, and Orally Bioavailable Inhibitors of Lipoprotein-Associated Phospholipase A2
    Liu Q, Huang F, Yuan X, Wang K, Zou Y, Shen J, Xu Y
    Ref: Journal of Medicinal Chemistry, 60:10231, 2017 : PubMed


Representative scheme of PAF-Acetylhydrolase structure and an image from PDBsum server


PDB-Sum5YE9 Previously Class, Architecture, Topology and Homologous superfamily - PDB-Sum server
FSSP5YE9 Fold classification based on Structure-Structure alignment of Proteins - FSSP server
SCOP5YE9 Structural Classification Of Protein - SCOP server
PROTEOPEDIA5ye9 3D, interactive encyclopedia of proteins - PROTEOPEDIA server

Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
For technical information about these pages see:
ESTHER Home Page and ACEDB Home Page
AcePerl Lincoln Stein Home Page

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