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Structure Report for: 5KBY

Name|Crystal structure of dipeptidyl peptidase IV in complex with SYR-472
Revelation date|13-Jul-2016
Family|DPP4N_Peptidase_S9: there are 829 genes in this family, 179 structure(s)
PDB File|ESTHER: header of PDB entry RCSB: Full entry
Skene, R.J., Jennings, A.J.
Ligand|Inhibitor: Trelagliptin Ligand in structure: Ligplot


    Title: Trelagliptin (SYR-472, Zafatek), Novel Once-Weekly Treatment for Type 2 Diabetes, Inhibits Dipeptidyl Peptidase-4 (DPP-4) via a Non-Covalent Mechanism
    Grimshaw CE, Jennings A, Kamran R, Ueno H, Nishigaki N, Kosaka T, Tani A, Sano H, Kinugawa Y and Takeuchi K <2 more author(s)>
    Ref: PLoS ONE, 11:e0157509, 2016 : PubMed


Representative scheme of DPP4N_Peptidase_S9 structure and an image from PDBsum server

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PDB-Sum5KBY Previously Class, Architecture, Topology and Homologous superfamily - PDB-Sum server
FSSP5KBY Fold classification based on Structure-Structure alignment of Proteins - FSSP server
SCOP5KBY Structural Classification Of Protein - SCOP server
PROTEOPEDIA5kby 3D, interactive encyclopedia of proteins - PROTEOPEDIA server

Send your questions or comments to :
Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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