5HQ3

Name : Human acetylcholinesterase designed variant expressed in bacteria

Revelation date : 27-Jul-2016

Family : ACHE

Gene_locus : human-ACHE

PDB file : ESTHER: header of PDB entry RCSB: Full entry

Comment
Goldenzweig, A., Goldsmith, M., Hill, S.E., Gertman, O., Laurino, P.,
Ashani, Y., Dym, O., Albeck, S., Unger, T., Prilusky, J., Lieberman, R.L.,
Aharoni, A., Silman, I., Sussman, J.L., Tawfik, D.S., Fleishman, S.J. (51 substitutions)
(V12T,K23T,M42V,L48R,V60W,S67N,E91N,T109K,S110N,T112A,L115M,A127S,Q140R,A141T,
T144V,V187I,V226I,G234A,T238Y,G240S,M241R,G242E,T249L,H253K,T275N,A278P,
V280E,S309P,A318N,H322K,V331N,Q325D,A357E,A361E,V378I,R393K,L394N,E396D,V408I,
L414F,G416Q,L418Y,Q421N,A434S,S438P,L441E,A467K,Q474R,G506D,A507E,Q509K)
>5HQ3
MEGREDAELLVTTRGGRLRGIRLTTPGGPVSAFLGIPFAEPPVGPRRFRPPEPKQPWSGVWDATTFQNVCYQYVDTLYPG
FEGTEMWNPNRNLSEDCLYLNVWTPYPRPKNPAPVMVWIYGGGFYSGSSSLDVYDGRFLVRTERVVLVSMNYRVGAFGFL
ALPGSREAPGNVGLLDQRLALQWVQENIAAFGGDPTSVTLFGESAGAASVGMHLLSPPSRGLFHRAILQSGAPNAPWAYV
SREEARRRALQLAKLVGCPPGGTGGNDTELVACLRNRPPQELVNHEWHVLPQESVFRFSFVPVVDGDFLPDTPEALINNG
DFKGLDVLVGVNKDEGSYFLVYGAPGFSKDNESLISREEFLEGVRVGVPQVSDLAAEAIVLHYTDWLHPEDPAKNRDALS
DVVGDHNVICPVAQFAQRYAANGARVYAYVFEHRSSTLPWPEWMGVPHGYEIEFIFGIPLDPSRNYTKEEKIFARRLMRY
WANFARTGDPNEPRDPKAPQWPPYTADEQKYVSLDLRPLEVRRGLRAQACAFWNRFLPKLLSATDTLD

Ligand :