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Structure Report for: 5FRD

Name|Structure of a thermophilic esterase
Revelation date|25-May-2016
Family|6_AlphaBeta_hydrolase: there are 3803 genes in this family, 55 structure(s)
Gene_locus|arcfu-est2
PDB File|ESTHER: header of PDB entry RCSB: Full entry
Comment|
Sayer, C., Finnigan, W., Isupov, M.N., Levisson, M., Kengen, S.W.M., van der Oost, J., Harmer, N., Littlechild, J.A.:
A thermophilic esterase with high activity towards short- to medium-chain
p-nitrophenyl carboxylic esters with optimal activity towards the valerate ester.
The AF-Est2 has good solvent and pH stability and is very thermostable,
showing no loss of activity after incubation for 30min at 80 C.
The structure reveals a bound CoA molecule in the vicinity of the active site
Ligand|Substrate: Coenzyme-A Ligand in structure: Ligplot


Reference

    Title: Structural and biochemical characterisation of Archaeoglobus fulgidus esterase reveals a bound CoA molecule in the vicinity of the active site
    Sayer C, Finnigan W, Isupov MN, Levisson M, Kengen SW, Van der Oost J, Harmer NJ, Littlechild JA
    Ref: Sci Rep, 6:25542, 2016 : PubMed

            



Representative scheme of 6_AlphaBeta_hydrolase structure and an image from PDBsum server

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Databases

PDB-Sum5FRD Previously Class, Architecture, Topology and Homologous superfamily - PDB-Sum server
FSSP5FRD Fold classification based on Structure-Structure alignment of Proteins - FSSP server
SCOP5FRD Structural Classification Of Protein - SCOP server
PROTEOPEDIA5frd 3D, interactive encyclopedia of proteins - PROTEOPEDIA server



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Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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