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Structure Report for: 4PNZ

Name|Human dipeptidyl peptidase IV/CD26 in complex with the long-acting inhibitor Omarigliptin (MK-3102)
Revelation date|09-Apr-2014
Family|DPP4N_Peptidase_S9: there are 829 genes in this family, 179 structure(s)
PDB File|ESTHER: header of PDB entry RCSB: Full entry
Biftu, T., Sinha-Roy, R., Chen, P., Qian, X., Feng, D., Kuethe, J.T., Scapin, G., Gao, Y.D., Yan, Y., Krueger, D., Bak, A., Eiermann, G., He, J., Cox, J., Hicks, J., Lyons, K.A., He, H., Salituro, G., Tong, S., Patel, S., Doss, G., Petrov, A., Wu, J., Xu, S.S., Sewall, C., Zhang, X., Zhang, B., Thornberry, N.A., Weber, A.E
Ligand|Inhibitor: Omarigliptin Ligand in structure: Ligplot


    Title: Omarigliptin (MK-3102): a novel long-acting DPP-4 inhibitor for once-weekly treatment of type 2 diabetes
    Biftu T, Sinha-Roy R, Chen P, Qian X, Feng D, Kuethe JT, Scapin G, Gao YD, Yan Y and Weber AE <19 more author(s)>
    Ref: Journal of Medicinal Chemistry, 57:3205, 2014 : PubMed


Representative scheme of DPP4N_Peptidase_S9 structure and an image from PDBsum server

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PDB-Sum4PNZ Previously Class, Architecture, Topology and Homologous superfamily - PDB-Sum server
FSSP4PNZ Fold classification based on Structure-Structure alignment of Proteins - FSSP server
SCOP4PNZ Structural Classification Of Protein - SCOP server
PROTEOPEDIA4pnz 3D, interactive encyclopedia of proteins - PROTEOPEDIA server

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Mail to: Nicolas Lenfant, Thierry Hotelier, Yves Bourne, Pascale Marchot and Arnaud Chatonnet.
Please cite: Lenfant 2013 Nucleic.Acids.Res. or Marchot Chatonnet 2012 Prot.Pept Lett.
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